• The Brewers are -110 favorites vs the Cardinals
• Brewers vs Cardinals Over / Under today: 8 Runs
• Brewers / Cardinals TV Channel: CATV | BRTV

The Milwaukee Brewers (-110) visit Busch Stadium to take on the St. Louis Cardinals (-110) on May 6, 2026. First pitch is scheduled for 1:15 pm in St. Louis, MO.

This season, the Brewers are 18-16 against the spread (ATS), while the Cardinals are 22-12 ATS.

Brewers vs Cardinals Starting Pitchers Today:

• Brewers starting pitcher: Brandon Sproat 0-2, 6.76 ERA
• Cardinals starting pitcher: Andre Pallante 3-2, 3.70 ERA

Brewers vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Brewers vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Wednesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Brewers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Bets Today:

• Sal Frelick has hit the Home Runs Over in 2 of his last 6 games (+15.00 Units / 250% ROI)
• Brice Turang has hit the Hits Under in 15 of his last 25 away games (+10.80 Units / 35% ROI)
• Brice Turang has hit the Total Bases Under in 18 of his last 25 away games (+9.70 Units / 26% ROI)
• Garrett Mitchell has hit the Walks Over in 7 of his last 10 away games (+8.05 Units / 81% ROI)
• Jackson Chourio has hit the RBIs Under in his last 8 away games (+8.00 Units / 43% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• JJ Wetherholt has hit the Home Runs Over in 4 of his last 10 games (+25.10 Units / 251% ROI)
• Jordan Walker has hit the Runs Over in 18 of his last 25 games (+17.70 Units / 71% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.55 Units / 40% ROI)
• Jordan Walker has hit the Hits Over in 20 of his last 25 games (+10.45 Units / 21% ROI)
• Nolan Gorman has hit the Singles Over in 9 of his last 15 games at home (+9.30 Units / 62% ROI)

Brewers Best Bets Today:

• The Milwaukee Brewers have covered the Run Line in 25 of their last 45 games (+9.15 Units / 17% ROI)
• The Milwaukee Brewers have hit the Team Total Under in 19 of their last 30 away games (+6.25 Units / 18% ROI)
• The Milwaukee Brewers have hit the Game Total Under in 15 of their last 25 away games (+5.25 Units / 19% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 30 games (+3.90 Units / 11% ROI)
• The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 9 of their last 16 away games (+2.65 Units / 14% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 21 of their last 35 games (+10.90 Units / 31% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 11 of their last 17 games (+9.35 Units / 54% ROI)
• The St. Louis Cardinals have covered the Run Line in 15 of their last 19 games (+9.10 Units / 31% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 50 games at home (+7.70 Units / 13% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 13 of their last 17 games (+7.50 Units / 34% ROI)

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 20-14 against the Run Line (+9.5 Units / 23.99% ROI).

• 18-16 when betting on the Moneyline for -3.4 Units / -7.54% ROI
• 17-16 when betting on the total runs Over for -0.65 Units / -1.73% ROI
• 16-17 when betting on the total runs Under for -2.6 Units / -6.97% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 22-12 against the Run Line (+4.8 Units / 9.28% ROI).

• 21-14 when betting on the Moneyline for +10.9 Units / 30.62% ROI
• 18-15 when betting on the total runs Over for +1.45 Units / 3.78% ROI
• 15-18 when betting on the total runs Under for -5.05 Units / -13.05% ROI

Cardinals vs Brewers Home Run Prop Bets Today

Cardinals vs Brewers Total Hits Prop Bets Today

Cardinals vs Brewers Strikeout Prop Bets Today

Brewers Keys to the Game vs. the Cardinals

The Brewers are 86-9 (.905) when scoring 5 or more runs since the 2025 season — 2nd best in MLB; League Avg: .795.

The Brewers are 53-44 (.546) on the road since the 2025 season — 2nd best in MLB; League Avg: .458.

The Brewers are just 3-14 (.176) when scoring 4 or fewer runs this season — 2nd lowest in MLB; League Avg: .275.

The Brewers are 33-13 (.717) when they’ve scored in the first inning since the 2025 season — 5th best in MLB; League Avg: .634.

Cardinals Keys to the Game vs. the Brewers

The Cardinals are 15-5 (.750) vs top 10 scoring offenses this season Today, they face the Brewers (fifth in runs scored).

The Cardinals are 8-6 (.571) vs the top 10 runs allowed teams this season Today, they face Brewers (fifth in runs allowed).

The Cardinals are 17-1 (.944) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .856.

The Cardinals are 13-7 (.650) after a win this season — 4th best in MLB; League Avg: .530.

Brewers Hitting Stats & Trends

Brewers hitters are slugging just .300 against LHP this season — 2nd lowest in MLB.

Brewers hitters have an OBP of .339 (3,869 PA’s) on the road since the 2025 season — best in MLB.

Brewers hitters have chased just 19% pitches with the pitcher behind in the count since the 2025 season — lowest in MLB.

Brewers hitters have an OPS of just .618 (397 PA’s) against LHP this season — 3rd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .496 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OPS of .775 (425 PA’s) in innings 7-9 this season — 5th best in MLB.

Cardinals hitters have 132 extra-base hits out of 448 total hits (just 29%) against LHP since the 2025 season — 3rd lowest in MLB.

Brewers Pitching Stats & Trends

Brewers pitchers have a strikeout rate of 45% with two-strikes this season — 5th best in MLB.

Brewers pitchers have a strikeout rate of 25% this season — best in MLB.

Brewers pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — tied for 4th highest in MLB.

Brewers pitchers have walked 9% of batters when facing the leadoff batter in the inning since the 2025 season — 5th highest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 35% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 21% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have struck out just 17% of left-handed batters they faced this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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