Brewers vs Pirates Prediction, Odds & Player Prop Bets Today – MLB, Sep 16

Pittsburgh Pirates' Jack Suwinski hits a home run off Chicago Cubs starting pitcher Jameson Taillon during the first inning of a baseball game Tuesday, June 13, 2023, in Chicago.
(AP Photo/Charles Rex Arbogast)
Odds Boost: Same Game Parlay
  • The Brewers are -140 favorites vs the Pirates
  • Brewers vs Pirates Over / Under today: 7.5 Runs
  • Brewers / Pirates TV Channel: BRTV | SNPT

The Milwaukee Brewers (-140) visit PNC Park to take on the Pittsburgh Pirates (+115) on September 16, 2026. First pitch is scheduled for 6:40 pm in Pittsburgh, PA.

This season, the Brewers are 94-57 against the spread (ATS), while the Pirates are 71-76 ATS.

Brewers vs Pirates Starting Pitchers Today:

  • Brewers starting pitcher: Logan Henderson 10-3, 2.35 ERA
  • Pirates starting pitcher: Jared Jones 4-6, 4.10 ERA

Brewers vs. Pirates Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Brewers-1.5 +125O 7.5 -105-140
Pirates +1.5 -155U 7.5 -115+115

Brewers vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Wednesday‘s MLB game with 59.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Brewers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Bets Today:

  • Jake Bauers has hit the Walks Over in 20 of his last 25 away games (+19.75 Units / 73% ROI)
  • William Contreras has hit the Home Runs Over in 4 of his last 7 games (+18.30 Units / 261% ROI)
  • Joey Ortiz has hit the Total Bases Over in 21 of his last 25 games (+16.20 Units / 42% ROI)
  • Joey Ortiz has hit the Hits Over in 21 of his last 25 games (+14.75 Units / 36% ROI)
  • William Contreras has hit the Singles Under in 19 of his last 25 away games (+13.20 Units / 48% ROI)

And here are some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

  • Nick Gonzales has hit the Runs Under in 18 of his last 20 games (+13.85 Units / 35% ROI)
  • Spencer Horwitz has hit the Total Bases Under in 14 of his last 15 games at home (+12.65 Units / 53% ROI)
  • Brandon Lowe has hit the Home Runs Over in 3 of his last 7 games at home (+10.30 Units / 147% ROI)
  • Brandon Lowe has hit the Hits Over in 20 of his last 25 games at home (+9.95 Units / 20% ROI)
  • Henry Davis has hit the Hits Runs and RBIs Under in 8 of his last 10 games (+7.05 Units / 66% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 24 of their last 40 games (+11.65 Units / 18% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 50 games (+10.30 Units / 18% ROI)
  • The Milwaukee Brewers have hit the Moneyline in 20 of their last 30 games (+7.10 Units / 16% ROI)
  • The Milwaukee Brewers have covered the Run Line in 17 of their last 30 games (+5.95 Units / 18% ROI)
  • The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 24 of their last 40 games (+5.85 Units / 13% ROI)
  • The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 20 games (+13.00 Units / 57% ROI)
  • The Pittsburgh Pirates have hit the Game Total Under in 16 of their last 24 games (+10.55 Units / 40% ROI)
  • The Pittsburgh Pirates have hit the Team Total Under in 31 of their last 50 games (+10.55 Units / 19% ROI)
  • The Pittsburgh Pirates have hit the Moneyline in 10 of their last 15 games (+4.55 Units / 23% ROI)
  • The Pittsburgh Pirates have covered the Run Line in 5 of their last 7 games (+3.40 Units / 33% ROI)

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 79-72 against the Run Line (+17.7 Units / 10.31% ROI).

  • 94-57 when betting on the Moneyline for +15.3 Units / 6.82% ROI
  • 67-79 when betting on the total runs Over for -19.35 Units / -11.66% ROI
  • 79-67 when betting on the total runs Under for +5.5 Units / 3.3% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 71-76 against the Run Line (-11.15 Units / -5.83% ROI).

  • 75-76 when betting on the Moneyline for -11.55 Units / -6.2% ROI
  • 76-68 when betting on the total runs Over for +1.3 Units / 0.78% ROI
  • 68-76 when betting on the total runs Under for -15.25 Units / -9.2% ROI

Brewers Keys to the Game vs. the Pirates

The Brewers are 15-2 (.882) when tied entering the 7th inning this season — best in MLB.

The Brewers are 20-17 (.541) when their opponents score in the first inning this season — 2nd best in MLB.

The Brewers are 11-46 (.193) when trailing entering the 8th inning this season — best in MLB.

The Brewers are 30-47 (.390) when scoring 4 or fewer runs this season — 3rd best in MLB.

Pirates Keys to the Game vs. the Brewers

The Pirates are just 10-24 (.294) when their opponents score in the first inning this season — 5th lowest in MLB.

The Pirates are just 6-36 (.143) when allowing 10 or more hits this season — 2nd lowest in MLB.

The Pirates were just 10-32 (.238) when their opponents score in the first inning in the 2024 season — 3rd lowest in MLB; League Avg: .359.

The Pirates are just 19-54 (.260) when their opponents score in the first inning since the 2025 season — 3rd lowest in MLB.

The Brewers are batting .401 on the first pitch of at-bats this season — best in MLB.

Brewers hitters have an OBP of .348 (4,084 PA’s) against RHP this season — best in MLB.

Brewers hitters have come to the plate with runners in scoring position in 1,754 of their 5,883 plate appearances (30%) this season — highest in MLB.

The Brewers are batting .292 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Pirates hitters have struck out in 26% of their PA’s against LHP this season — 2nd highest in MLB.

Pirates hitters have an OBP of .347 (2,812 PA’s) at home this season — 3rd best in MLB.

Pirates hitters have 118 extra-base hits out of 404 total hits (just 29%) against LHP this season — 3rd lowest in MLB.

The Pirates are batting just .225 with two outs this season — tied for 5th lowest in MLB.

The Brewers have won 60% of home games in which their opponents scored first this season — highest in MLB.

The Brewers have won 49% of games in which their opponents scored first this season — highest in MLB.

The longest HR allowed by the Brewers pitchers this season traveled 523.9 feet — — 2nd longest in MLB

Brewers pitchers have a strikeout rate of 28% in the first 5 innings this season — best in MLB.

The Pirates have won just 28% of home games in which their opponents scored first this season — tied for 2nd lowest in MLB.

The Pirates have won just 23% of games in which their opponents scored first this season — 3rd lowest in MLB.

Pirates pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

The Pirates pitchers have allowed their opponents to score first in just 44% of their games this season — 2nd lowest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.