• The Brewers are -190 favorites vs the Cardinals
• Cardinals vs Brewers Over / Under today: 8 Runs
• Cardinals / Brewers TV Channel: CATV | BRTV

The St. Louis Cardinals (+155) visit American Family Field to take on the Milwaukee Brewers (-190) on September 25, 2026. First pitch is scheduled for 7:40 pm in Milwaukee, WI.

This season, the Cardinals are 77-82 against the spread (ATS), while the Brewers are 82-77 ATS.

Cardinals vs Brewers Starting Pitchers Today:

• Cardinals starting pitcher: Michael McGreevy 7-9, 3.88 ERA
• Brewers starting pitcher: Robert Gasser 5-5, 4.01 ERA

Cardinals vs. Brewers Odds, Run Line, Over/Under & Moneyline

Cardinals vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Friday‘s MLB game with 61.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 19 of his last 25 away games (+15.35 Units / 58% ROI)
• Nathan Church has hit the Hits Over in 21 of his last 25 away games (+14.45 Units / 35% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Under in 14 of his last 15 games (+13.10 Units / 74% ROI)
• Masyn Winn has hit the Total Bases Under in 17 of his last 25 away games (+11.30 Units / 36% ROI)
• Jose Fermin has hit the Runs Over in 5 of his last 6 away games (+8.10 Units / 135% ROI)

And here are some favorite MLB player prop bets for Brewers players for Friday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Best Bets Today:

• William Contreras has hit the Home Runs Over in 4 of his last 6 games at home (+19.70 Units / 328% ROI)
• Joey Ortiz has hit the Total Bases Over in 17 of his last 20 games (+15.00 Units / 49% ROI)
• Joey Ortiz has hit the Hits Over in 18 of his last 20 games (+13.80 Units / 38% ROI)
• Sal Frelick has hit the Singles Under in 18 of his last 25 games (+11.20 Units / 41% ROI)
• Brice Turang has hit the Walks Over in 13 of his last 20 games at home (+10.65 Units / 53% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 28 of their last 50 away games (+17.10 Units / 32% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 35 of their last 50 away games (+16.30 Units / 27% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 28 of their last 45 games (+11.25 Units / 22% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 31 of their last 50 away games (+10.00 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 10 games (+8.05 Units / 61% ROI)

Brewers Best Bets Today:

• The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games (+11.70 Units / 17% ROI)
• The Milwaukee Brewers have hit the Moneyline in 26 of their last 35 games at home (+10.75 Units / 18% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 24 games at home (+10.25 Units / 38% ROI)
• The Milwaukee Brewers have covered the Run Line in 26 of their last 50 games at home (+8.25 Units / 16% ROI)
• The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 16 of their last 24 games at home (+7.00 Units / 25% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 86-70 against the Run Line (-0.2 Units / -0.09% ROI).

• 77-82 when betting on the Moneyline for +0.25 Units / 0.14% ROI
• 73-79 when betting on the total runs Over for -14.55 Units / -8.28% ROI
• 79-73 when betting on the total runs Under for -1.25 Units / -0.72% ROI

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 82-77 against the Run Line (+15.4 Units / 8.48% ROI).

• 100-59 when betting on the Moneyline for +19.1 Units / 8.13% ROI
• 71-83 when betting on the total runs Over for -19.75 Units / -11.3% ROI
• 83-71 when betting on the total runs Under for +5.15 Units / 2.94% ROI

Cardinals Keys to the Game vs. the Brewers

The Cardinals are just 6-15 (.286) when tied entering the 8th inning this season — tied for 2nd lowest in MLB.

The Cardinals are just 29-18 (.617) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are 9-59 (.132) when trailing entering the 8th inning this season — 5th best in MLB.

The Cardinals are just 26-37 (.413) when tied entering the 8th inning since the 2024 season — 4th lowest in MLB.

Brewers Keys to the Game vs. the Cardinals

The Brewers are 20-17 (.541) when their opponents score in the first inning this season — 2nd best in MLB.

The Brewers are 13-45 (.224) when trailing entering the 7th inning this season — best in MLB.

The Brewers are 17-3 (.850) when tied entering the 7th inning this season — best in MLB.

The Brewers are 11-47 (.190) when trailing entering the 8th inning this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .357 at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .374 against RHP this season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .686 (4,213 PA’s) against RHP this season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .662 (2,971 PA’s) at home this season — 2nd lowest in MLB.

Brewers Hitting Stats & Trends

The Brewers are batting .402 on the first pitch of at-bats this season — best in MLB.

Brewers hitters have an OBP of .345 (4,297 PA’s) against RHP this season — best in MLB.

Brewers hitters have come to the plate with runners in scoring position in 1,828 of their 6,187 plate appearances (29%) this season — highest in MLB.

Brewers hitters have an OBP of .340 (6,187 PA’s) this season — best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 4th highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 37% of their games on the road this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.

Cardinals pitchers have 189 three-pitch strikeouts this season — 3rd fewest in MLB.

Brewers Pitching Stats & Trends

The Brewers have won 60% of home games in which their opponents scored first this season — highest in MLB.

The Brewers have won 49% of games in which their opponents scored first this season — highest in MLB.

In games when their opponents have scored three or more runs in an inning, the Brewers have still managed to win 38% of the time this season — highest in MLB.

The longest HR allowed by the Brewers pitchers this season traveled 523.9 feet — — 2nd longest in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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