• The Cardinals are -105 favorites vs the Giants
• Cardinals vs Giants Over / Under today: 7.5 Runs
• Cardinals / Giants TV Channel: NSBA | CATV

The St. Louis Cardinals (-105) visit Oracle Park to take on the San Francisco Giants (-115) on September 8, 2026. First pitch is scheduled for 9:45 pm in San Francisco, CA.

This season, the Cardinals are 72-73 against the spread (ATS), while the Giants are 70-73 ATS.

Cardinals vs Giants Starting Pitchers Today:

• Cardinals starting pitcher: Quinn Mathews 1-2, 4.38 ERA
• Giants starting pitcher: Landen Roupp 8-13, 4.18 ERA

Cardinals vs. Giants Odds, Run Line, Over/Under & Moneyline

Cardinals vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 16 of his last 20 away games (+14.25 Units / 67% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 16 of his last 20 away games (+13.15 Units / 54% ROI)
• Alec Burleson has hit the RBIs Over in 15 of his last 25 games (+13.15 Units / 52% ROI)
• Nathan Church has hit the Hits Over in 17 of his last 20 away games (+11.90 Units / 36% ROI)
• Joshua Baez has hit the Home Runs Over in 3 of his last 7 games (+10.45 Units / 149% ROI)

And here are some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Rafael Devers has hit the Home Runs Over in 5 of his last 8 games (+15.10 Units / 189% ROI)
• Rafael Devers has hit the Total Bases Over in 18 of his last 25 games (+14.85 Units / 57% ROI)
• Rafael Devers has hit the Runs Over in 16 of his last 20 games (+14.30 Units / 68% ROI)
• Bryce Eldridge has hit the Hits Over in 21 of his last 25 games (+14.20 Units / 32% ROI)
• Rafael Devers has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+13.25 Units / 46% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 26 of their last 45 away games (+16.15 Units / 33% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 18 of their last 23 games (+13.80 Units / 55% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 31 of their last 45 away games (+13.65 Units / 25% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 29 of their last 45 away games (+11.65 Units / 22% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 18 games (+8.70 Units / 41% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 19 of their last 23 games (+15.35 Units / 56% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 19 of their last 23 games at home (+14.45 Units / 52% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 16 of their last 23 games at home (+12.75 Units / 46% ROI)
• The San Francisco Giants have hit the Team Total Over in 12 of their last 16 games (+7.40 Units / 39% ROI)
• The San Francisco Giants have hit the Game Total Over in 13 of their last 23 games (+4.35 Units / 17% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 80-62 against the Run Line (+3.35 Units / 1.67% ROI).

• 72-73 when betting on the Moneyline for +6.05 Units / 3.84% ROI
• 66-72 when betting on the total runs Over for -13.5 Units / -8.45% ROI
• 72-66 when betting on the total runs Under for -0.75 Units / -0.47% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 70-73 against the Run Line (-21.3 Units / -10.67% ROI).

• 60-85 when betting on the Moneyline for -20.35 Units / -12.71% ROI
• 67-65 when betting on the total runs Over for -4.5 Units / -2.82% ROI
• 65-67 when betting on the total runs Under for -8.5 Units / -5.34% ROI

Cardinals Keys to the Game vs. the Giants

The Cardinals are just 27-17 (.614) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are 5-58 (.079) when trailing entering the 9th inning this season — 5th best in MLB.

The Cardinals are just 6-13 (.316) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are 8-53 (.131) when trailing entering the 8th inning this season — 5th best in MLB.

Giants Keys to the Game vs. the Cardinals

The Giants are just 1-62 (.016) when trailing entering the 7th inning this season — lowest in MLB.

The Giants are just 1-66 (.015) when trailing entering the 8th inning this season — lowest in MLB.

The Giants are just 19-28 (.404) vs bottom 10 scoring offenses this season Today, they face the Cardinals (10th in runs scored).

The Giants are just 8-41 (.163) when allowing 10 or more hits this season — 3rd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

The Cardinals are batting .284 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

Cardinals hitters have an OBP of .359 (655 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Cardinals hitters are slugging just .361 at home this season — 2nd lowest in MLB.

Giants Hitting Stats & Trends

The Giants are batting .257 with two outs this season — 2nd best in MLB.

The Giants have a winning percentage of just 35% on the road this season — tied for 2nd lowest in MLB.

29% of Giants hitters strikeouts have come on 95+ MPH fastballs this season — 3rd highest in MLB.

Giants hitters have an OPS of just .674 (1,555 PA’s) against LHP this season — 4th lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — 5th highest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 5th lowest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 34% of their games on the road this season — lowest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 126 double plays in 1,093 opportunities (12%) this season — best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 59% of opposing batters this season — lowest in MLB.

The Giants have won just 5% of road games in which their opponents scored first this season — lowest in MLB.

Giants pitchers have walked 10% of batters this season — tied for 5th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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