• The Cardinals are +100 favorites vs the Reds
• Cardinals vs Reds Over / Under today: 9.5 Runs
• Cardinals / Reds TV Channel: CATV | RDTV | KMOV

The St. Louis Cardinals (+100) visit Great American Ball Park to take on the Cincinnati Reds (-120) on May 22, 2026. First pitch is scheduled for 6:40 pm in Cincinnati, OH.

This season, the Cardinals are 28-21 against the spread (ATS), while the Reds are 30-19 ATS.

Cardinals vs Reds Starting Pitchers Today:

• Cardinals starting pitcher: Kyle Leahy 5-3, 3.97 ERA
• Reds starting pitcher: Chris Paddack 0-5, 6.88 ERA

Cardinals vs. Reds Odds, Run Line, Over/Under & Moneyline

Cardinals vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Reds will win Friday‘s MLB game with 52.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Victor Scott II has hit the Home Runs Over in 2 of his last 7 away games (+24.00 Units / 343% ROI)
• Victor Scott II has hit the Singles Under in 20 of his last 25 games (+11.35 Units / 26% ROI)
• Alec Burleson has hit the Runs Over in 13 of his last 20 away games (+10.25 Units / 51% ROI)
• Alec Burleson has hit the Hits Over in 16 of his last 20 games (+9.95 Units / 24% ROI)
• Ivan Herrera has hit the Walks Under in 13 of his last 15 games (+9.90 Units / 35% ROI)

And here are some favorite MLB player prop bets for Reds players for Friday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Nate Lowe has hit the Home Runs Over in 4 of his last 9 games at home (+17.30 Units / 192% ROI)
• Tyler Stephenson has hit the Runs Under in 22 of his last 25 games (+16.85 Units / 35% ROI)
• Spencer Steer has hit the Total Bases Over in 17 of his last 20 games (+16.25 Units / 62% ROI)
• Spencer Steer has hit the Hits Over in 18 of his last 20 games (+15.20 Units / 43% ROI)
• Will Benson has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+12.45 Units / 38% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 15 of their last 21 away games (+12.15 Units / 57% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 16 of their last 22 away games (+9.05 Units / 35% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 11 of their last 18 away games (+8.35 Units / 45% ROI)
• The St. Louis Cardinals have covered the Run Line in 14 of their last 18 away games (+7.75 Units / 27% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 10 of their last 14 away games (+6.70 Units / 44% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Over in 28 of their last 40 games (+14.55 Units / 33% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 9 of their last 11 games (+7.20 Units / 56% ROI)
• The Cincinnati Reds have covered the Run Line in 30 of their last 50 games (+5.95 Units / 8% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 7 of their last 11 games (+5.05 Units / 36% ROI)
• The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 15 of their last 24 games (+5.05 Units / 17% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 30-18 against the Run Line (+3.65 Units / 4.96% ROI).

• 28-21 when betting on the Moneyline for +11.5 Units / 22.84% ROI
• 22-24 when betting on the total runs Over for -4.4 Units / -8.19% ROI
• 24-22 when betting on the total runs Under for -0.45 Units / -0.83% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 30-19 against the Run Line (+5.95 Units / 8.11% ROI).

• 26-24 when betting on the Moneyline for +1.5 Units / 2.63% ROI
• 31-18 when betting on the total runs Over for +11 Units / 19.89% ROI
• 18-31 when betting on the total runs Under for -16 Units / -29.25% ROI

Cardinals Keys to the Game vs. the Reds

The Cardinals are 3-18 (.143) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .055.

The Cardinals are 10-3 (.769) vs the bottom 10 runs allowed teams this season Today, they face the Reds (25th runs allowed).

The Cardinals are 15-8 (.652) on the road this season — tied for 2nd best in MLB; League Avg: .472.

The Cardinals are 149-10 (.937) when leading entering the 8th inning since the 2024 season — tied for 4th best in MLB; League Avg: .903.

Reds Keys to the Game vs. the Cardinals

The Reds are 3-21 (.125) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .055.

The Reds are 4-16 (.200) when trailing entering the 7th inning this season — tied for 5th best in MLB; League Avg: .137.

The Reds are 22-4 (.846) when allowing 4 or fewer runs this season — 3rd best in MLB; League Avg: .721.

The Reds are just 12-50 (.194) when allowing 10 or more hits since the 2025 season — 5th lowest in MLB; League Avg: .254.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have put 39% of their swings in play against LHP this season — 4th highest in MLB.

Games involving the Cardinals went OVER in 85% of their games (62.3% ROI) vs the bottom 10 runs allowed teams this season Today, they face the Reds (25th runs allowed).

The Cardinals are batting just .219 when facing the starting pitcher for the 3rd time in a game this season — 4th lowest in MLB.

Reds Hitting Stats & Trends

The Reds are batting just .214 with runners on base this season — lowest in MLB.

Reds hitters have drawn walks in 12% of their PA’s against LHP this season — 2nd best in MLB.

The Reds are batting just .229 this season — 4th lowest in MLB.

Reds hitters have chased 24% of pitches out of the zone with runners in scoring position this season — lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 19% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 37% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 2nd lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — tied for 4th highest in MLB.

Reds Pitching Stats & Trends

Reds pitchers have walked 12% of batters this season — 3rd highest in MLB.

Reds pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — tied for 3rd highest in MLB.

Reds pitchers have a first-pitch strike rate of just 57% this season — lowest in MLB.

Reds pitchers have a strike rate of just 61% this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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