• The Cardinals are -125 favorites vs the Royals
• Cardinals vs Royals Over / Under today: 8.5 Runs
• Cardinals / Royals TV Channel: RYTV | CATV

The St. Louis Cardinals (-125) visit Kauffman Stadium to take on the Kansas City Royals (+105) on June 21, 2026. First pitch is scheduled for 2:10 pm in Kansas City, MO.

This season, the Cardinals are 40-34 against the spread (ATS), while the Royals are 33-41 ATS.

Cardinals vs Royals Starting Pitchers Today:

• Cardinals starting pitcher: Dustin May 5-6, 3.80 ERA
• Royals starting pitcher: Stephen Kolek 4-1, 2.70 ERA

Cardinals vs. Royals Odds, Run Line, Over/Under & Moneyline

Cardinals vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Sunday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Royals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Alec Burleson has hit the Home Runs Over in 5 of his last 8 away games (+17.50 Units / 219% ROI)
• Alec Burleson has hit the RBIs Over in 13 of his last 20 games (+13.35 Units / 67% ROI)
• Jordan Walker has hit the Hits Over in 12 of his last 15 games (+10.75 Units / 41% ROI)
• Ivan Herrera has hit the Total Bases Under in 19 of his last 25 games (+10.70 Units / 27% ROI)
• Ivan Herrera has hit the Walks Over in 8 of his last 10 away games (+10.30 Units / 103% ROI)

And here are some favorite MLB player prop bets for Royals players for Sunday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

• Lane Thomas has hit the Home Runs Over in 3 of his last 7 games (+13.20 Units / 189% ROI)
• Salvador Perez has hit the Hits Under in 12 of his last 20 games at home (+12.00 Units / 60% ROI)
• Salvador Perez has hit the RBIs Under in 17 of his last 20 games (+11.10 Units / 26% ROI)
• Jac Caglianone has hit the Singles Over in 14 of his last 20 games (+10.60 Units / 52% ROI)
• Michael Massey has hit the Runs Over in 13 of his last 25 games at home (+8.80 Units / 35% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 25 of their last 35 away games (+13.45 Units / 32% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games (+11.40 Units / 19% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 14 of their last 18 games (+10.25 Units / 47% ROI)
• The St. Louis Cardinals have covered the Run Line in 32 of their last 50 games (+10.15 Units / 14% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 24 of their last 50 games (+7.15 Units / 13% ROI)

Royals Best Bets Today:

• The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 18 games (+7.75 Units / 38% ROI)
• The Kansas City Royals have hit the Team Total Over in 6 of their last 8 games (+4.10 Units / 45% ROI)
• The Kansas City Royals have hit the Game Total Over in 6 of their last 8 games (+3.70 Units / 41% ROI)
• The Kansas City Royals have covered the 1st Five Innings (F5) Run Line in 11 of their last 18 games (+3.60 Units / 17% ROI)
• The Kansas City Royals have hit the Moneyline in 10 of their last 18 games (+2.20 Units / 11% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 45-28 against the Run Line (+8.7 Units / 8.18% ROI).

• 40-34 when betting on the Moneyline for +10.05 Units / 12.8% ROI
• 33-37 when betting on the total runs Over for -7.4 Units / -9.14% ROI
• 37-33 when betting on the total runs Under for +0.45 Units / 0.55% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 33-41 against the Run Line (-16.55 Units / -15.68% ROI).

• 32-45 when betting on the Moneyline for -17.5 Units / -19.8% ROI
• 36-40 when betting on the total runs Over for -7.8 Units / -9.21% ROI
• 40-36 when betting on the total runs Under for +0.55 Units / 0.65% ROI

Royals vs Cardinals Home Run Prop Bets Today

Royals vs Cardinals Total Hits Prop Bets Today

Royals vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Royals

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 32-20 (.615) when tied entering the 7th inning since the 2024 season — 4th best in MLB; League Avg: .499.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Royals Keys to the Game vs. the Cardinals

The Royals are just 24-8 (.750) when leading entering the 8th inning this season — lowest in MLB; League Avg: .896.

The Royals are just 24-6 (.800) when leading entering the 9th inning this season — 2nd lowest in MLB; League Avg: .945.

The Royals are just 3-24 (.111) when allowing 10 or more hits this season — 2nd lowest in MLB; League Avg: .248.

The Royals are just 29-38 (.433) when allowing 5 or more extra base hits this season — 2nd lowest in MLB; League Avg: .536.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have 105 extra-base hits out of 354 total hits (just 30%) against starting pitchers this season — lowest in MLB.

Cardinals hitters have an OBP of .330 (837 PA’s) against LHP this season — 5th best in MLB.

Cardinals hitters have 54 extra-base hits out of 184 total hits (just 29%) against LHP this season — 5th lowest in MLB.

Royals Hitting Stats & Trends

Royals hitters are slugging just .229 with two-strikes this season — lowest in MLB.

29% of Royals hitters strikeouts have come on 95+ MPH fastballs this season — tied for 3rd highest in MLB.

Royals hitters have struck out in just 20% of their PA’s against LHP this season — 4th best in MLB.

Royals hitters are slugging just .364 with runners on base this season — lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 20% this season — 5th lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 90.3 MPH (1,935 batted balls) this season — highest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 2nd lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — tied for 2nd highest in MLB.

Royals Pitching Stats & Trends

Royals pitchers have picked-off 11 runners from first base this season — 2nd most in MLB.

Royals pitchers have a strikeout rate of just 18% in close and late situations this season — lowest in MLB.

Royals pitchers have a strikeout rate of just 19% in late innings this season — 2nd lowest in MLB.

Opponents have a chase percentage of just 28% against the Royals pitchers this season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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