• The Cubs are -120 favorites vs the Cardinals
• Cubs vs Cardinals Over / Under today: 8 Runs
• Cubs / Cardinals TV Channel: MARQ | CATV

The Chicago Cubs (-120) visit Busch Stadium to take on the St. Louis Cardinals (+100) on July 29, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Cubs are 61-46 against the spread (ATS), while the Cardinals are 58-46 ATS.

Cubs vs Cardinals Starting Pitchers Today:

• Cubs starting pitcher: Matthew Boyd 6-1, 3.86 ERA
• Cardinals starting pitcher: Dustin May 5-7, 4.64 ERA

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 54.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Seiya Suzuki has hit the RBIs Over in 14 of his last 25 games (+12.60 Units / 50% ROI)
• Seiya Suzuki has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.20 Units / 40% ROI)
• Alex Bregman has hit the Home Runs Over in 3 of his last 6 away games (+11.80 Units / 197% ROI)
• Ian Happ has hit the Walks Over in 12 of his last 15 games (+11.80 Units / 78% ROI)
• Seiya Suzuki has hit the Runs Over in 17 of his last 25 games (+9.85 Units / 35% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Blaze Jordan has hit the Runs Under in 22 of his last 25 games (+16.15 Units / 29% ROI)
• Jose Fermin has hit the Home Runs Over in 2 of his last 8 games at home (+13.00 Units / 162% ROI)
• Nelson Velazquez has hit the Singles Under in 13 of his last 15 games (+9.75 Units / 38% ROI)
• JJ Wetherholt has hit the Hits Under in 14 of his last 25 games (+9.75 Units / 33% ROI)
• Jimmy Crooks III has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+9.65 Units / 51% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 20 of their last 30 games (+15.30 Units / 44% ROI)
• The Chicago Cubs have hit the Moneyline in 17 of their last 22 away games (+12.80 Units / 53% ROI)
• The Chicago Cubs have hit the Team Total Over in 31 of their last 50 away games (+10.20 Units / 18% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 15 of their last 22 away games (+7.45 Units / 28% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 21 of their last 40 games (+6.45 Units / 12% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 18 of their last 24 games at home (+11.40 Units / 43% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 17 of their last 23 games at home (+11.30 Units / 43% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 19 games at home (+8.35 Units / 35% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 25 of their last 45 games at home (+2.25 Units / 4% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 21 of their last 45 games (+2.00 Units / 4% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 49-57 against the Run Line (-5.15 Units / -4.11% ROI).

• 61-46 when betting on the Moneyline for +3.2 Units / 2.24% ROI
• 58-48 when betting on the total runs Over for +5.8 Units / 4.92% ROI
• 48-58 when betting on the total runs Under for -15.25 Units / -12.96% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 58-46 against the Run Line (-1.25 Units / -0.82% ROI).

• 53-54 when betting on the Moneyline for +2.25 Units / 1.95% ROI
• 44-58 when betting on the total runs Over for -20.1 Units / -17.04% ROI
• 58-44 when betting on the total runs Under for +9.45 Units / 8.04% ROI

Cardinals vs Cubs Home Run Prop Bets Today

Cardinals vs Cubs Total Hits Prop Bets Today

Cardinals vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Cardinals

The Cubs are 26-1 (.963) when they’ve had 5 or more XBH this season — 2nd best in MLB; League Avg: .790.

The Cubs are 21-6 (.778) when they’ve scored in the first inning this season — 2nd best in MLB; League Avg: .631.

The Cubs are 33-4 (.892) when they’ve had 10 or more hits this season — 2nd best in MLB; League Avg: .753.

The Cubs are 4-43 (.085) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .052.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are just 4-38 (.095) when trailing entering the 7th inning this season — 4th lowest in MLB; League Avg: .136.

The Cardinals are just 4-38 (.095) when trailing entering the 7th inning since the 2025 season — 4th lowest in MLB; League Avg: .136.

The Cardinals are just 4-38 (.095) when trailing entering the 7th inning since the 2024 season — 4th lowest in MLB; League Avg: .136.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .357 (1,156 PA’s) against LHP this season — best in MLB.

Cubs hitters are slugging .435 against LHP this season — 4th best in MLB.

Cubs hitters have an OBP of .355 (2,051 PA’s) at home this season — best in MLB.

The Cubs are batting .267 against LHP this season — tied for 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters are slugging just .380 against RHP this season — tied for 3rd lowest in MLB.

Cardinals hitters have 187 extra-base hits out of 599 total hits (just 31%) against RHP this season — 3rd lowest in MLB.

Cardinals hitters are slugging just .360 at home this season — 3rd lowest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have picked-off 16 runners from first base this season — most in MLB.

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 37% of the time this season — highest in MLB.

Opponents have a groundball batting average of just .218 against Cubs pitchers with runners on base this season — 2nd best in MLB.

Cubs pitchers have a strikeout rate of just 39% with two-strikes this season — tied for 5th lowest in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 33% of their games on the road this season — 2nd lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 89.8 MPH (2,804 batted balls) this season — tied for highest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — tied for 2nd lowest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 89.8 MPH this season (2,804 balls in play) — tied for highest in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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