• The Cubs are -145 favorites vs the Cardinals
• Cubs vs Cardinals Over / Under today: 8 Runs
• Cubs / Cardinals TV Channel: MARQ | CATV | KMOV

The Chicago Cubs (-145) visit Busch Stadium to take on the St. Louis Cardinals (+118) on May 29, 2026. First pitch is scheduled for 7:15 pm in St. Louis, MO.

This season, the Cubs are 31-26 against the spread (ATS), while the Cardinals are 32-21 ATS.

Cubs vs Cardinals Starting Pitchers Today:

• Cubs starting pitcher: Shota Imanaga 4-5, 4.04 ERA
• Cardinals starting pitcher: Andre Pallante 5-4, 3.74 ERA

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 60.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Moises Ballesteros has hit the Hits Under in 16 of his last 20 games (+15.75 Units / 69% ROI)
• Michael Busch has hit the Walks Over in 18 of his last 25 games (+14.10 Units / 55% ROI)
• Moises Ballesteros has hit the Singles Under in 17 of his last 20 games (+13.20 Units / 47% ROI)
• Alex Bregman has hit the Total Bases Over in his last 10 away games (+12.90 Units / 111% ROI)
• Ian Happ has hit the Home Runs Over in 3 of his last 8 away games (+11.90 Units / 149% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Ivan Herrera has hit the Home Runs Over in 2 of his last 4 games at home (+15.00 Units / 375% ROI)
• Alec Burleson has hit the Runs Under in 16 of his last 20 games at home (+9.30 Units / 27% ROI)
• Masyn Winn has hit the Total Bases Under in 8 of his last 9 games (+7.80 Units / 66% ROI)
• Alec Burleson has hit the Hits Over in 18 of his last 25 games (+7.55 Units / 15% ROI)
• Alec Burleson has hit the Singles Over in his last 7 games at home (+7.00 Units / 74% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 18 games (+9.95 Units / 46% ROI)
• The Chicago Cubs have hit the Game Total Over in 29 of their last 50 games (+7.45 Units / 14% ROI)
• The Chicago Cubs have hit the Team Total Under in 13 of their last 18 games (+7.00 Units / 31% ROI)
• The Chicago Cubs have hit the Moneyline in 23 of their last 40 games (+4.10 Units / 8% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 1 of their last 5 away games (+0.65 Units / 12% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 15 of their last 22 games (+9.50 Units / 39% ROI)
• The St. Louis Cardinals have hit the Moneyline in 27 of their last 50 games (+8.25 Units / 16% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 16 of their last 23 games at home (+7.60 Units / 27% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 40 games at home (+7.20 Units / 15% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 17 of their last 35 games (+4.90 Units / 13% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 23-34 against the Run Line (-12.6 Units / -18.54% ROI).

• 31-26 when betting on the Moneyline for -1.05 Units / -1.36% ROI
• 32-24 when betting on the total runs Over for +6.2 Units / 9.91% ROI
• 24-32 when betting on the total runs Under for -11 Units / -17.45% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 32-21 against the Run Line (+2.9 Units / 3.66% ROI).

• 29-25 when betting on the Moneyline for +8.4 Units / 15.12% ROI
• 23-28 when betting on the total runs Over for -7.8 Units / -13.16% ROI
• 28-23 when betting on the total runs Under for +2.45 Units / 4.11% ROI

Cardinals vs Cubs Home Run Prop Bets Today

Cardinals vs Cubs Total Hits Prop Bets Today

Cardinals vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Cardinals

The Cubs are 21-9 (.700) after a win this season — 2nd best in MLB; League Avg: .531.

The Cubs are 23-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .865.

The Cubs are 10-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .792.

The Cubs are 25-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .899.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 16-11 (.593) vs top 10 scoring offenses this season Today, they face the Cubs (seventh in runs scored).

The Cardinals are 3-22 (.120) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .051.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Cubs Hitting Stats & Trends

Cubs hitters have drawn walks in 14% of their PA’s when leading off an inning this season — best in MLB.

Cubs hitters have drawn walks in 12% of their PA’s against RHP this season — best in MLB.

Cubs hitters have an OBP of .345 (636 PA’s) against LHP this season — 2nd best in MLB.

Cubs hitters have an OBP of .343 (1,126 PA’s) at home this season — 4th best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — tied for 2nd best in MLB.

The Cardinals are batting just .209 with two outs this season — 5th lowest in MLB.

Cardinals hitters have an OBP of just .308 (554 PA’s) with runners in scoring position this season — lowest in MLB.

Cardinals hitters have 71 extra-base hits out of 251 total hits (just 28%) against starting pitchers this season — lowest in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .196 against Cubs pitchers with runners on base this season — best in MLB.

Opponents have a groundball batting average of just .222 against Cubs pitchers this season — tied for 3rd best in MLB.

Cubs pitchers have picked-off 9 runners from first base this season — tied for most in MLB.

Cubs pitchers have allowed an exit velocity over 105 MPH 163 times this season — 4th most in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 17% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — tied for 2nd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 20% this season — 3rd lowest in MLB.

Opponents have a groundball rate of 47% against Cardinals pitchers this season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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