• The Cubs are -135 favorites vs the Guardians
• Cubs vs Guardians Over / Under today: 8 Runs
• Cubs / Guardians TV Channel: FOX

The Chicago Cubs (-135) visit Progressive Field to take on the Cleveland Guardians (+115) on April 4, 2026. First pitch is scheduled for 7:15 pm in Cleveland, OH.

This season, the Cubs are 3-4 against the spread (ATS), while the Guardians are 5-3 ATS.

Cubs vs Guardians Starting Pitchers Today:

• Cubs starting pitcher: Shota Imanaga 0-1, 7.21 ERA
• Guardians starting pitcher: Slade Cecconi 0-1, 12.47 ERA

Cubs vs. Guardians Odds, Run Line, Over/Under & Moneyline

Cubs vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 59.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Ian Happ has hit the Singles Under in 20 of his last 25 games (+12.60 Units / 31% ROI)
• Michael Busch has hit the Home Runs Over in 4 of his last 9 away games (+11.25 Units / 125% ROI)
• Michael Busch has hit the Walks Over in 14 of his last 25 games (+10.95 Units / 44% ROI)
• Dansby Swanson has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+10.15 Units / 31% ROI)
• Dansby Swanson has hit the Hits Under in 15 of his last 25 games (+9.40 Units / 37% ROI)

And here are some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 2 of his last 5 games at home (+20.00 Units / 400% ROI)
• Steven Kwan has hit the Hits Under in 10 of his last 15 games (+10.65 Units / 59% ROI)
• Slade Cecconi has hit the Strikeouts Under in his last 9 games at home (+9.40 Units / 91% ROI)
• Steven Kwan has hit the Singles Under in 11 of his last 15 games (+8.15 Units / 53% ROI)
• Jose Ramirez has hit the Total Bases Under in 18 of his last 25 games at home (+8.00 Units / 23% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 81 of their last 161 games (+14.70 Units / 6% ROI)
• The Chicago Cubs have hit the Game Total Under in 64 of their last 117 games (+13.65 Units / 11% ROI)
• The Chicago Cubs have hit the Team Total Under in 20 of their last 26 away games (+13.15 Units / 42% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 46 games (+11.35 Units / 20% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 27 of their last 46 games (+5.45 Units / 10% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 49 of their last 77 games (+21.25 Units / 23% ROI)
• The Cleveland Guardians have hit the Game Total Under in 72 of their last 128 games (+17.40 Units / 12% ROI)
• The Cleveland Guardians have covered the Run Line in 47 of their last 82 games (+13.00 Units / 12% ROI)
• The Cleveland Guardians have hit the Team Total Under in 45 of their last 77 games at home (+9.59 Units / 11% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 44 of their last 78 games (+8.55 Units / 10% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 3-4 against the Run Line (-0.6 Units / -8.11% ROI).

• 3-4 when betting on the Moneyline for -4.05 Units / -31.27% ROI
• 3-4 when betting on the total runs Over for -1.25 Units / -16.56% ROI
• 4-3 when betting on the total runs Under for +0.7 Units / 8.92% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 5-3 against the Run Line (+0.95 Units / 8.37% ROI).

• 5-3 when betting on the Moneyline for +5.1 Units / 62.96% ROI
• 3-5 when betting on the total runs Over for -2.5 Units / -28.41% ROI
• 5-3 when betting on the total runs Under for +1.7 Units / 19.32% ROI

Cubs Keys to the Game vs. the Guardians

The Cubs were 46-24 (.657) after a loss in the 2025 season — best in MLB; League Avg: .483.

The Cubs were 48-6 (.889) when they had 10 or more hits in the 2025 season — best in MLB; League Avg: .743.

The Cubs were 40-9 (.816) when they scored in the first inning in the 2025 season — best in MLB; League Avg: .636.

The Cubs were 42-39 (.519) on the road in the 2025 season — 4th best in MLB; League Avg: .457.

Guardians Keys to the Game vs. the Cubs

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians were 69-4 (.945) when leading entering the 8th inning in the 2025 season — 4th best in MLB; League Avg: .909.

The Guardians were just 73-5 (.936) when leading entering the 9th inning in the 2025 season — 5th lowest in MLB; League Avg: .956.

The Guardians were 66-5 (.930) when leading entering the 7th inning in the 2025 season — 2nd best in MLB; League Avg: .875.

Cubs Hitting Stats & Trends

Cubs hitters have an OPS of just .493 (70 PA’s) in innings 7-9 this season — 2nd lowest in MLB.

Cubs hitters have a swing rate of just 39% in righty-righty matchups this season — lowest in MLB.

Cubs hitters slugged .441 on the road in the 2025 season — 3rd best in MLB.

Cubs hitters have an OPS of just .797 (55 PA’s) with the pitcher behind in the count this season — 3rd lowest in MLB.

Guardians Hitting Stats & Trends

The Guardians are batting just .189 in righty-righty matchups since the 2025 season — lowest in MLB.

The Guardians batted just .186 in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters had an OPS of just .545 (690 PA’s) in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters struck out in 32% of their PA’s in righty-righty matchups in the 2025 season — highest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers walked 7% of batters in the 2025 season — best in MLB.

Cubs pitchers have not struck out any hitters in 5 PA’s in close and late situations this season — lowest in MLB.

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers picked-off 25 runners from first base in the 2025 season — most in MLB.

Guardians Pitching Stats & Trends

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Guardians pitchers had an ERA of 3.72 (706.0 IP) on the road in the 2025 season — tied for best in MLB.

Guardians pitchers have a strikeout rate of 43% in close and late situations this season — best in MLB.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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