• The Cubs are -135 favorites vs the Reds
• Cubs vs Reds Over / Under today: 8.5 Runs
• Cubs / Reds TV Channel: MARQ | RDTV

The Chicago Cubs (-135) visit Great American Ball Park to take on the Cincinnati Reds (+110) on September 18, 2026. First pitch is scheduled for 6:40 pm in Cincinnati, OH.

This season, the Cubs are 85-68 against the spread (ATS), while the Reds are 77-74 ATS.

Cubs vs Reds Starting Pitchers Today:

• Cubs starting pitcher: Clay Holmes 6-7, 2.86 ERA
• Reds starting pitcher: Chase Burns 15-3, 2.82 ERA

Cubs vs. Reds Odds, Run Line, Over/Under & Moneyline

Cubs vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 52.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Reds and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Michael Conforto has hit the Home Runs Over in 3 of his last 7 away games (+13.10 Units / 187% ROI)
• Michael Conforto has hit the Runs Under in 21 of his last 25 games (+12.80 Units / 26% ROI)
• Alex Bregman has hit the Walks Over in 13 of his last 25 away games (+9.80 Units / 39% ROI)
• Pedro Ramirez has hit the Singles Under in 12 of his last 15 games (+8.20 Units / 42% ROI)
• Ian Happ has hit the Hits Runs and RBIs Over in 11 of his last 15 away games (+7.25 Units / 43% ROI)

And here are some favorite MLB player prop bets for Reds players for Friday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Elly De La Cruz has hit the Home Runs Over in 5 of his last 10 games (+18.20 Units / 182% ROI)
• Elly De La Cruz has hit the Hits Runs and RBIs Over in 17 of his last 20 games (+14.40 Units / 63% ROI)
• Elly De La Cruz has hit the Total Bases Over in 18 of his last 25 games (+14.05 Units / 50% ROI)
• TJ Friedl has hit the Hits Under in 19 of his last 25 games (+13.35 Units / 49% ROI)
• Elly De La Cruz has hit the Runs Over in 15 of his last 20 games (+12.75 Units / 62% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 26 of their last 40 away games (+14.90 Units / 31% ROI)
• The Chicago Cubs have hit the Game Total Over in 31 of their last 50 games (+13.60 Units / 25% ROI)
• The Chicago Cubs have hit the Team Total Over in 33 of their last 50 away games (+13.60 Units / 23% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 18 of their last 23 games (+13.05 Units / 49% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 16 of their last 23 games (+11.05 Units / 34% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 33 of their last 50 games at home (+12.90 Units / 21% ROI)
• The Cincinnati Reds have hit the Team Total Under in 31 of their last 50 games at home (+8.25 Units / 14% ROI)
• The Cincinnati Reds have hit the Game Total Under in 28 of their last 50 games at home (+7.45 Units / 14% ROI)
• The Cincinnati Reds have hit the Moneyline in 14 of their last 25 games at home (+4.75 Units / 17% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 14 of their last 35 games at home (+1.85 Units / 4% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 73-78 against the Run Line (-1.25 Units / -0.7% ROI).

• 85-68 when betting on the Moneyline for -1.75 Units / -0.85% ROI
• 85-64 when betting on the total runs Over for +15.4 Units / 9.13% ROI
• 64-85 when betting on the total runs Under for -28.85 Units / -17.15% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 77-74 against the Run Line (-15.4 Units / -7.34% ROI).

• 71-82 when betting on the Moneyline for -7.3 Units / -4.3% ROI
• 80-69 when betting on the total runs Over for +3.85 Units / 2.28% ROI
• 69-80 when betting on the total runs Under for -18.65 Units / -11.12% ROI

Cubs Keys to the Game vs. the Reds

The Cubs are 30-35 (.462) when allowing 2 or more home runs this season — best in MLB.

The Cubs are 6-61 (.090) when trailing entering the 9th inning this season — 2nd best in MLB.

The Cubs are 47-6 (.887) when they’ve had 10 or more hits this season — tied for 2nd best in MLB.

The Cubs are 33-18 (.647) vs bottom 10 scoring offenses this season Today, they face the Reds (26th in runs scored).

Reds Keys to the Game vs. the Cubs

The Reds are 7-74 (.086) when trailing entering the 9th inning this season — tied for 3rd best in MLB.

The Reds are just 30-41 (.423) after a win this season — 5th lowest in MLB.

The Reds are just 8-17 (.320) when tied entering the 7th inning this season — 5th lowest in MLB.

The Reds were just 5-16 (.238) when tied entering the 8th inning in the 2024 season — lowest in MLB; League Avg: .500.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .340 (6,026 PA’s) this season — 2nd best in MLB.

Cubs hitters have an OBP of .368 (620 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Cubs hitters have an OBP of .350 (1,604 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .800 (1,604 PA’s) against LHP this season — best in MLB.

Reds Hitting Stats & Trends

The Reds are batting just .207 with two outs this season — lowest in MLB.

The Reds are batting just .227 with runners on base this season — lowest in MLB.

Reds hitters have struck out in 25% of their PA’s against LHP this season — tied for 3rd highest in MLB.

Reds hitters have struck out in 26% of their PA’s against RHP this season — highest in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .215 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have picked-off 22 runners from first base this season — most in MLB.

Opponents have a groundball batting average of just .224 against Cubs pitchers this season — tied for best in MLB.

Cubs pitchers have won 35% of games in which they have allowed their opponent to score in three different innings this season — 2nd highest in MLB.

Reds Pitching Stats & Trends

Reds pitchers have walked 11% of batters this season — highest in MLB.

The Reds pitchers have allowed their opponents to score first in 63% of their games this season — highest in MLB.

Reds pitchers have an ERA of 5.80 (431.1 IP) against division opponents this season — 2nd highest in MLB.

Reds pitchers have allowed an average Exit Velocity of 89.5 MPH (3,872 batted balls) this season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Cubs vs Reds and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.