• The Cubs are -160 favorites vs the Reds
• Cubs vs Reds Over / Under today: 9.5 Runs
• Cubs / Reds TV Channel: MARQ | RDTV

The Chicago Cubs (-160) visit Great American Ball Park to take on the Cincinnati Reds (+135) on September 20, 2026. First pitch is scheduled for 1:40 pm in Cincinnati, OH.

This season, the Cubs are 86-69 against the spread (ATS), while the Reds are 78-75 ATS.

Cubs vs Reds Starting Pitchers Today:

• Cubs starting pitcher: Undecided 0-0, 0.00 ERA
• Reds starting pitcher: Rhett Lowder 6-11, 5.77 ERA

Cubs vs. Reds Odds, Run Line, Over/Under & Moneyline

Cubs vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Ian Happ has hit the Home Runs Over in 4 of his last 9 away games (+14.40 Units / 160% ROI)
• Michael Conforto has hit the Runs Under in 21 of his last 25 games (+12.80 Units / 26% ROI)
• Alex Bregman has hit the Walks Over in 7 of his last 9 away games (+9.80 Units / 109% ROI)
• Nico Hoerner has hit the Singles Over in 19 of his last 25 away games (+9.65 Units / 25% ROI)
• Nico Hoerner has hit the Hits Over in 17 of his last 25 away games (+9.55 Units / 22% ROI)

And here are some favorite MLB player prop bets for Reds players for Sunday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Elly De La Cruz has hit the Total Bases Over in 18 of his last 25 games (+14.10 Units / 51% ROI)
• Elly De La Cruz has hit the Home Runs Over in 4 of his last 8 games at home (+13.50 Units / 169% ROI)
• Elly De La Cruz has hit the Hits Over in 21 of his last 25 games (+12.50 Units / 24% ROI)
• Elly De La Cruz has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.40 Units / 42% ROI)
• Elly De La Cruz has hit the Runs Over in 17 of his last 25 games (+11.45 Units / 44% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 29 of their last 45 away games (+15.85 Units / 29% ROI)
• The Chicago Cubs have hit the Team Total Over in 33 of their last 50 away games (+13.65 Units / 23% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 19 of their last 25 games (+13.10 Units / 45% ROI)
• The Chicago Cubs have hit the Game Total Over in 28 of their last 45 games (+12.65 Units / 25% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 17 of their last 25 games (+12.05 Units / 34% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 33 of their last 50 games at home (+12.90 Units / 20% ROI)
• The Cincinnati Reds have hit the Game Total Under in 29 of their last 50 games at home (+9.45 Units / 17% ROI)
• The Cincinnati Reds have hit the Team Total Under in 31 of their last 50 games at home (+8.20 Units / 14% ROI)
• The Cincinnati Reds have hit the Moneyline in 13 of their last 24 games at home (+3.90 Units / 14% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 13 of their last 35 games at home (+0.85 Units / 2% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 74-79 against the Run Line (-1.1 Units / -0.61% ROI).

• 86-69 when betting on the Moneyline for -2.25 Units / -1.07% ROI
• 86-65 when betting on the total runs Over for +15.25 Units / 8.93% ROI
• 65-86 when betting on the total runs Under for -28.95 Units / -16.99% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 78-75 against the Run Line (-15.75 Units / -7.41% ROI).

• 72-83 when betting on the Moneyline for -7.05 Units / -4.11% ROI
• 81-70 when betting on the total runs Over for +3.7 Units / 2.16% ROI
• 70-81 when betting on the total runs Under for -18.75 Units / -11.04% ROI

Cubs Keys to the Game vs. the Reds

The Cubs are 47-6 (.887) when they’ve had 10 or more hits this season — tied for 2nd best in MLB.

The Cubs are 18-28 (.391) when allowing 10 or more hits this season — best in MLB.

The Cubs are 6-62 (.088) when trailing entering the 9th inning this season — 2nd best in MLB.

The Cubs are 31-11 (.738) when they’ve scored in the first inning this season — 5th best in MLB.

Reds Keys to the Game vs. the Cubs

The Reds are just 8-17 (.320) when tied entering the 7th inning this season — 5th lowest in MLB.

The Reds are just 30-42 (.417) after a win this season — 5th lowest in MLB.

The Reds are 7-75 (.085) when trailing entering the 9th inning this season — 4th best in MLB.

The Reds are just 23-40 (.365) when tied entering the 8th inning since the 2024 season — lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .340 (6,104 PA’s) this season — 2nd best in MLB.

Cubs hitters have an OPS of .797 (1,636 PA’s) against LHP this season — best in MLB.

Cubs hitters are slugging .506 on breaking pitches against LHP this season — best in MLB.

Cubs hitters have an OPS of .773 (1,924 PA’s) in innings 7-9 this season — best in MLB.

Reds Hitting Stats & Trends

Reds hitters have struck out in 26% of their PA’s against RHP this season — tied for highest in MLB.

The Reds are batting just .227 with runners on base this season — lowest in MLB.

Reds hitters have an OPS of just .689 (4,313 PA’s) against RHP this season — 3rd lowest in MLB.

Reds hitters have an OBP of just .299 (4,313 PA’s) against RHP this season — lowest in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .217 against Cubs pitchers with runners on base this season — best in MLB.

Opponents have a groundball batting average of just .224 against Cubs pitchers this season — best in MLB.

Cubs pitchers have picked-off 22 runners this season — most in MLB.

Cubs pitchers have picked-off 22 runners from first base this season — most in MLB.

Reds Pitching Stats & Trends

Reds pitchers have walked 11% of batters this season — highest in MLB.

The Reds pitchers have allowed their opponents to score first in 68% of their games at home this season — highest in MLB.

The Reds pitchers have allowed their opponents to score first in 63% of their games this season — highest in MLB.

Reds pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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