• The Cubs are -135 favorites vs the White Sox
• Cubs vs White Sox Over / Under today: 8.5 Runs
• Cubs / White Sox TV Channel: MARQ | CHSN | WCIU

The Chicago Cubs (-135) visit Rate Field to take on the Chicago White Sox (+110) on May 17, 2026. First pitch is scheduled for 2:10 pm in Chicago, IL.

This season, the Cubs are 29-17 against the spread (ATS), while the White Sox are 25-19 ATS.

Cubs vs White Sox Starting Pitchers Today:

• Cubs starting pitcher: Colin Rea 4-2, 4.65 ERA
• White Sox starting pitcher: Erick Fedde 0-4, 3.80 ERA

Cubs vs. White Sox Odds, Run Line, Over/Under & Moneyline

Cubs vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 60.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Ian Happ has hit the Walks Over in 16 of his last 20 games (+13.60 Units / 61% ROI)
• Nico Hoerner has hit the Hits Under in 21 of his last 25 games (+12.40 Units / 22% ROI)
• Matt Shaw has hit the Singles Under in 17 of his last 20 away games (+12.05 Units / 37% ROI)
• Alex Bregman has hit the RBIs Under in 21 of his last 25 games (+11.30 Units / 20% ROI)
• Michael Conforto has hit the Runs Over in 10 of his last 15 away games (+10.65 Units / 71% ROI)

And here are some favorite MLB player prop bets for White Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Chase Meidroth has hit the Runs Over in 16 of his last 25 games (+14.95 Units / 60% ROI)
• Chase Meidroth has hit the Hits Over in 21 of his last 25 games (+14.40 Units / 30% ROI)
• Colson Montgomery has hit the RBIs Over in 15 of his last 25 games (+14.35 Units / 57% ROI)
• Drew Romo has hit the Home Runs Over in 2 of his last 7 games at home (+14.00 Units / 200% ROI)
• Miguel Vargas has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.60 Units / 45% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Moneyline in 22 of their last 30 games (+14.65 Units / 38% ROI)
• The Chicago Cubs have hit the Team Total Over in 30 of their last 50 games (+8.60 Units / 15% ROI)
• The Chicago Cubs have hit the Game Total Over in 23 of their last 40 games (+5.65 Units / 13% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 6 of their last 7 games (+4.85 Units / 55% ROI)
• The Chicago Cubs have covered the Run Line in 16 of their last 30 games (+1.85 Units / 5% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 21 of their last 30 games (+10.75 Units / 31% ROI)
• The Chicago White Sox have hit the Moneyline in 16 of their last 24 games (+9.60 Units / 38% ROI)
• The Chicago White Sox have covered the Run Line in 13 of their last 17 games (+9.00 Units / 35% ROI)
• The Chicago White Sox have hit the Game Total Over in 29 of their last 50 games (+6.05 Units / 11% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 7 of their last 8 games (+5.90 Units / 59% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 21-25 against the Run Line (-4.2 Units / -7.75% ROI).

• 29-17 when betting on the Moneyline for +8.3 Units / 13.15% ROI
• 26-19 when betting on the total runs Over for +5.5 Units / 10.89% ROI
• 19-26 when betting on the total runs Under for -9.55 Units / -18.78% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 25-19 against the Run Line (-1.55 Units / -2.36% ROI).

• 23-22 when betting on the Moneyline for +5.45 Units / 11.7% ROI
• 26-19 when betting on the total runs Over for +5.25 Units / 10.67% ROI
• 19-26 when betting on the total runs Under for -9.75 Units / -19.58% ROI

White Sox vs Cubs Home Run Prop Bets Today

White Sox vs Cubs Total Hits Prop Bets Today

White Sox vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the White Sox

The Cubs are 8-0 (1.000) when they’ve scored in the first inning this season — best in MLB; League Avg: .633.

The Cubs are 23-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .895.

The Cubs are 19-4 (.826) vs the bottom 10 runs allowed teams this season Today, they face the White Sox (21st runs allowed).

The Cubs are 4-13 (.235) when trailing entering the 7th inning this season — 3rd best in MLB; League Avg: .136.

White Sox Keys to the Game vs. the Cubs

The White Sox are just 4-11 (.267) vs top 10 scoring offenses this season Today, they face the Cubs (third in runs scored).

The White Sox are just 63-18 (.778) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .873.

The White Sox are just 7-19 (.269) when tied entering the 8th inning since the 2025 season — lowest in MLB; League Avg: .500.

The White Sox are just 23-106 (.178) when scoring 4 or fewer runs since the 2025 season — 2nd lowest in MLB; League Avg: .285.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .274 (938 PA’s) with two-strikes this season — best in MLB.

Cubs hitters have an OBP of .363 (544 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .793 (914 PA’s) at home this season — 4th best in MLB.

Cubs hitters have an OBP of .362 (914 PA’s) at home this season — 3rd best in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have an OBP of .337 (479 PA’s) against LHP this season — 5th best in MLB.

White Sox hitters are slugging .676 on the first pitch of at-bats this season — 2nd best in MLB.

White Sox hitters are slugging .408 on the road this season — 5th best in MLB.

White Sox hitters are slugging .444 against LHP this season — 2nd best in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 8% of batters this season — 4th best in MLB.

Opponents have a groundball batting average of just .185 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have a strikeout rate of just 17% when facing the leadoff batter in the inning this season — tied for 2nd lowest in MLB.

Cubs pitchers have an ERA of 3.04 (213.0 IP) at home this season — 5th best in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

White Sox pitchers have walked 11% of batters this season — 5th highest in MLB.

White Sox pitchers have a strikeout rate of just 39% with two-strikes this season — 4th lowest in MLB.

Opponents have a miss rate of just 23% against White Sox pitchers this season — 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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