• The Diamondbacks are -110 favorites vs the Astros
• Diamondbacks vs Astros Over / Under today: 8.5 Runs
• Diamondbacks / Astros TV Channel: FOX

The Arizona Diamondbacks (-110) visit Daikin Park to take on the Houston Astros (-110) on September 5, 2026. First pitch is scheduled for 7:15 pm in Houston, TX.

This season, the Diamondbacks are against the spread (ATS), while the Astros are ATS.

Diamondbacks vs Astros Starting Pitchers Today:

• Diamondbacks starting pitcher: Brandon Pfaadt 7-2, 3.49 ERA
• Astros starting pitcher: Ethan Pecko 1-0, 6.24 ERA

Diamondbacks vs. Astros Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Saturday‘s MLB game with 51.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Saturday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Gabriel Moreno has hit the Home Runs Over in 3 of his last 7 away games (+21.30 Units / 304% ROI)
• Corbin Carroll has hit the Walks Over in 17 of his last 25 away games (+17.15 Units / 69% ROI)
• Gabriel Moreno has hit the Total Bases Over in 17 of his last 25 games (+13.75 Units / 55% ROI)
• Lars Nootbaar has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+12.85 Units / 41% ROI)
• Gabriel Moreno has hit the Hits Over in 18 of his last 25 away games (+11.10 Units / 25% ROI)

And here are some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Jeremy Pena has hit the Hits Under in 18 of his last 25 games (+13.30 Units / 30% ROI)
• Christian Walker has hit the Total Bases Under in 15 of his last 20 games (+12.20 Units / 50% ROI)
• Taylor Trammell has hit the Runs Under in 14 of his last 15 games (+12.00 Units / 38% ROI)
• Isaac Paredes has hit the Walks Over in 11 of his last 15 games (+11.00 Units / 73% ROI)
• Jose Altuve has hit the Home Runs Over in 2 of his last 4 games at home (+10.60 Units / 265% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 31 of their last 50 away games (+10.95 Units / 18% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 15 of their last 24 away games (+10.90 Units / 43% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 25 of their last 40 away games (+8.70 Units / 20% ROI)
• The Arizona Diamondbacks have covered the Run Line in 9 of their last 14 games (+4.85 Units / 27% ROI)
• The Arizona Diamondbacks have hit the Team Total Under in 7 of their last 10 games (+3.50 Units / 29% ROI)

Astros Best Bets Today:

• The Houston Astros have covered the Run Line in 23 of their last 40 games (+9.35 Units / 19% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 24 games (+8.30 Units / 28% ROI)
• The Houston Astros have hit the Team Total Under in 8 of their last 11 games at home (+4.80 Units / 39% ROI)
• The Houston Astros have hit the Game Total Under in 8 of their last 11 games at home (+4.70 Units / 39% ROI)
• The Houston Astros have hit the Moneyline in 7 of their last 10 games (+4.65 Units / 40% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Diamondbacks Keys to the Game vs. the Astros

The Diamondbacks are 64-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks are just 112-25 (.818) when leading entering the 7th inning since the 2025 season — 5th lowest in MLB.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks are 9-124 (.068) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB.

Astros Keys to the Game vs. the Diamondbacks

The Astros are 12-5 (.706) when tied entering the 8th inning this season — 2nd best in MLB.

The Astros are 63-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Astros are 54-3 (.947) when leading entering the 7th inning this season — 2nd best in MLB.

The Astros are 85-59 (.590) after a loss since the 2025 season — 3rd best in MLB.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have struck out in just 18% of their PA’s against LHP this season — best in MLB.

The Diamondbacks are batting .276 against LHP this season — best in MLB.

Diamondbacks hitters have put 40% of their swings in play against LHP this season — tied for highest in MLB.

Diamondbacks hitters have an OPS of .782 (1,484 PA’s) against LHP this season — 2nd best in MLB.

Astros Hitting Stats & Trends

Astros hitters have drawn walks in 13% of their PA’s with runners in scoring position this season — best in MLB.

Astros hitters have 85 extra-base hits out of 198 total hits (43%) on the first pitch of at-bats this season — 2nd best in MLB.

Astros hitters have 42 extra-base hits out of 156 total hits (just 27%) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Astros hitters have put just 34% of balls in play to the right side of the field this season — 2nd lowest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 5th best in MLB.

Opponents have a miss rate of just 22% against Diamondbacks pitchers this season — 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 17% with runners in scoring position this season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have walked 11% of batters this season — highest in MLB.

The Astros have allowed 3.10 runs per game (440/142) in the first 5 innings this season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Diamondbacks vs Astros and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.