• The Diamondbacks are +100 favorites vs the Cardinals
• Diamondbacks vs Cardinals Over / Under today: 9 Runs
• Diamondbacks / Cardinals TV Channel: CATV | DBTV

The Arizona Diamondbacks (+100) visit Busch Stadium to take on the St. Louis Cardinals (-120) on June 24, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Diamondbacks are 40-39 against the spread (ATS), while the Cardinals are 46-29 ATS.

Diamondbacks vs Cardinals Starting Pitchers Today:

• Diamondbacks starting pitcher: Mitch Bratt 0-0, 0.00 ERA
• Cardinals starting pitcher: Matthew Liberatore 3-4, 5.23 ERA

Diamondbacks vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 52.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Ildemaro Vargas has hit the Hits Under in 17 of his last 25 games (+16.50 Units / 53% ROI)
• Ildemaro Vargas has hit the Total Bases Under in 17 of his last 20 games (+13.85 Units / 44% ROI)
• Ketel Marte has hit the Runs Under in 18 of his last 25 away games (+11.20 Units / 37% ROI)
• Corbin Carroll has hit the RBIs Under in 20 of his last 25 away games (+10.85 Units / 20% ROI)
• Ildemaro Vargas has hit the Singles Under in 15 of his last 20 games (+10.20 Units / 47% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Alec Burleson has hit the RBIs Over in 16 of his last 25 games at home (+16.55 Units / 66% ROI)
• Alec Burleson has hit the Singles Over in 16 of his last 20 games at home (+10.85 Units / 41% ROI)
• Ivan Herrera has hit the Total Bases Under in 16 of his last 20 games (+10.30 Units / 32% ROI)
• Jordan Walker has hit the Runs Under in his last 9 games (+9.00 Units / 75% ROI)
• Jose Fermin has hit the Hits Over in his last 8 games (+8.00 Units / 61% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 38 of their last 50 games (+25.60 Units / 43% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 30 of their last 45 games (+15.90 Units / 32% ROI)
• The Arizona Diamondbacks have hit the Team Total Over in 30 of their last 50 away games (+8.05 Units / 14% ROI)
• The Arizona Diamondbacks have covered the Run Line in 3 of their last 5 away games (+2.95 Units / 53% ROI)
• The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 games (+1.80 Units / 25% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 21 games (+11.35 Units / 46% ROI)
• The St. Louis Cardinals have covered the Run Line in 31 of their last 50 games (+9.85 Units / 14% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games (+9.40 Units / 16% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 26 of their last 45 games (+8.40 Units / 17% ROI)
• The St. Louis Cardinals have hit the Moneyline in 28 of their last 50 games (+8.35 Units / 15% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 44-33 against the Run Line (+5.75 Units / 5.43% ROI).

• 40-39 when betting on the Moneyline for -1.05 Units / -1.12% ROI
• 33-42 when betting on the total runs Over for -12.95 Units / -14.86% ROI
• 42-33 when betting on the total runs Under for +6.1 Units / 7.03% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 46-29 against the Run Line (+9 Units / 8.2% ROI).

• 42-35 when betting on the Moneyline for +10.95 Units / 13.29% ROI
• 34-39 when betting on the total runs Over for -8.6 Units / -10.21% ROI
• 39-34 when betting on the total runs Under for +1.35 Units / 1.58% ROI

Cardinals vs Diamondbacks Home Run Prop Bets Today

Cardinals vs Diamondbacks Total Hits Prop Bets Today

Cardinals vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Cardinals

The Diamondbacks are 34-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB; League Avg: .943.

The Diamondbacks are just 87-23 (.791) when leading entering the 7th inning since the 2025 season — tied for lowest in MLB; League Avg: .870.

The Diamondbacks are just 98-16 (.860) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .905.

The Diamondbacks are 7-98 (.067) when trailing entering the 9th inning since the 2025 season — tied for 4th best in MLB; League Avg: .048.

Cardinals Keys to the Game vs. the Diamondbacks

The Cardinals are just 10-95 (.095) when trailing entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .130.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals are 32-21 (.604) when tied entering the 7th inning since the 2024 season — 4th best in MLB; League Avg: .499.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have struck out in just 16% of their PA’s against LHP this season — best in MLB.

Diamondbacks hitters are slugging just .364 against RHP this season — lowest in MLB.

9% of Diamondbacks’ hitters plate appearances have lasted only one pitch (271/2,939 PA’s) this season — lowest in MLB.

Diamondbacks hitters have an OPS of just .666 (2,114 PA’s) against RHP this season — 2nd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have 111 extra-base hits out of 373 total hits (just 30%) against starting pitchers this season — lowest in MLB.

Cardinals hitters have an OBP of .330 (1,472 PA’s) on the road this season — 5th best in MLB.

Cardinals hitters have struck out in just 20% of their PA’s this season — 4th best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 4th best in MLB.

Diamondbacks pitchers have a strikeout rate of just 38% with two-strikes this season — 3rd lowest in MLB.

Diamondbacks pitchers have struck out just 17% of left-handed batters they faced this season — lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 22% against Cardinals pitchers this season — 2nd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 90.2 MPH (2,024 batted balls) this season — highest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 90.2 MPH this season (2,024 balls in play) — highest in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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