• The Cardinals are -145 favorites vs the Giants
• Giants vs Cardinals Over / Under today: 7.5 Runs
• Giants / Cardinals TV Channel: NSBA | CATV

The San Francisco Giants (+118) visit Busch Stadium to take on the St. Louis Cardinals (-145) on September 14, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Giants are 62-88 against the spread (ATS), while the Cardinals are 83-64 ATS.

Giants vs Cardinals Starting Pitchers Today:

• Giants starting pitcher: Landen Roupp 9-13, 4.01 ERA
• Cardinals starting pitcher: Quinn Mathews 1-3, 4.11 ERA

Giants vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Giants vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 55.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Giants players for Monday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

• Bryce Eldridge has hit the Total Bases Over in 16 of his last 20 games (+15.35 Units / 64% ROI)
• Jonah Cox has hit the Home Runs Over in 2 of his last 6 away games (+15.00 Units / 250% ROI)
• Bryce Eldridge has hit the Hits Over in 21 of his last 25 games (+14.10 Units / 32% ROI)
• Bryce Eldridge has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+13.95 Units / 52% ROI)
• Jung Hoo Lee has hit the Runs Under in 21 of his last 25 games (+13.05 Units / 24% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Nathan Church has hit the Hits Over in 18 of his last 20 games (+15.00 Units / 45% ROI)
• Leonardo Bernal has hit the Home Runs Over in 2 of his last 4 games (+13.00 Units / 325% ROI)
• Nathan Church has hit the Singles Over in 16 of his last 20 games (+12.90 Units / 61% ROI)
• Jose Fermin has hit the Runs Under in 17 of his last 20 games at home (+11.80 Units / 28% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.90 Units / 39% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 24 games (+17.85 Units / 60% ROI)
• The San Francisco Giants have hit the Team Total Over in 16 of their last 21 games (+10.50 Units / 43% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+7.25 Units / 13% ROI)
• The San Francisco Giants have hit the Game Total Over in 11 of their last 16 games (+6.55 Units / 37% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 21 of their last 35 games (+5.75 Units / 14% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 24 of their last 35 games (+14.05 Units / 36% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 22 of their last 40 games (+11.40 Units / 25% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 24 of their last 35 games (+10.70 Units / 25% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 23 games (+9.80 Units / 36% ROI)
• The St. Louis Cardinals have covered the Run Line in 11 of their last 13 games at home (+9.20 Units / 49% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 73-75 against the Run Line (-21.1 Units / -10.2% ROI).

• 62-88 when betting on the Moneyline for -21.35 Units / -12.93% ROI
• 71-66 when betting on the total runs Over for -1.65 Units / -1% ROI
• 66-71 when betting on the total runs Under for -11.85 Units / -7.2% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 83-64 against the Run Line (+4.35 Units / 2.09% ROI).

• 74-76 when betting on the Moneyline for +4.65 Units / 2.85% ROI
• 69-74 when betting on the total runs Over for -12.85 Units / -7.76% ROI
• 74-69 when betting on the total runs Under for -1.95 Units / -1.18% ROI

Giants Keys to the Game vs. the Cardinals

The Giants are just 2-65 (.030) when trailing entering the 7th inning this season — 2nd lowest in MLB.

The Giants are just 19-31 (.380) vs bottom 10 scoring offenses this season Today, they face the Cardinals (10th in runs scored).

The Giants are just 8-43 (.157) when allowing 10 or more hits this season — 3rd lowest in MLB.

The Giants are just 6-28 (.176) when allowing 2 or more home runs this season — 2nd lowest in MLB.

Cardinals Keys to the Game vs. the Giants

The Cardinals are just 28-17 (.622) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are just 66-33 (.667) when they’ve had 10 or more hits since the 2025 season — tied for 2nd lowest in MLB.

The Cardinals are just 13-25 (.342) when tied entering the 8th inning since the 2025 season — lowest in MLB.

Giants Hitting Stats & Trends

The Giants are batting .257 with two outs this season — 2nd best in MLB.

29% of Giants hitters strikeouts have come on 95+ MPH fastballs this season — highest in MLB.

Giants hitters have drawn walks in 8% of their PA’s against RHP this season — 2nd lowest in MLB.

Giants hitters are slugging .419 on the road this season — 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have an OBP of .357 (667 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Cardinals hitters have an OPS of just .667 (2,741 PA’s) at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .382 against RHP this season — 3rd lowest in MLB.

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

The Giants have won just 5% of road games in which their opponents scored first this season — lowest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 59% of opposing batters this season — lowest in MLB.

Opponents have a miss rate of just 23% against Giants pitchers this season — 5th lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 4th highest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 129 double plays in 1,128 opportunities (11%) this season — best in MLB.

Cardinals pitchers have 179 three-pitch strikeouts this season — 3rd fewest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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