• The Giants are -110 favorites vs the Reds
• Giants vs Reds Over / Under today: 9 Runs
• Giants / Reds TV Channel: NSBA | RDTV

The San Francisco Giants (-110) visit Great American Ball Park to take on the Cincinnati Reds (-110) on April 15, 2026. First pitch is scheduled for 6:40 pm in Cincinnati, OH.

This season, the Giants are 6-11 against the spread (ATS), while the Reds are 10-7 ATS.

Giants vs Reds Starting Pitchers Today:

• Giants starting pitcher: Tyler Mahle 0-2, 4.40 ERA
• Reds starting pitcher: Rhett Lowder 1-1, 3.24 ERA

Giants vs. Reds Odds, Run Line, Over/Under & Moneyline

Giants vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Reds will win Wednesday‘s MLB game with 52.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Giants vs Reds and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

• Matt Chapman has hit the Walks Under in 13 of his last 15 games (+10.00 Units / 39% ROI)
• Luis Arraez has hit the Runs Under in 16 of his last 20 away games (+9.85 Units / 31% ROI)
• Willy Adames has hit the Home Runs Over in 3 of his last 6 away games (+9.00 Units / 150% ROI)
• Matt Chapman has hit the Singles Over in 11 of his last 15 games (+8.80 Units / 58% ROI)
• Rafael Devers has hit the RBIs Under in his last 8 away games (+8.00 Units / 47% ROI)

And here are some favorite MLB player prop bets for Reds players for Wednesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Elly De La Cruz has hit the Home Runs Over in 4 of his last 9 games at home (+15.80 Units / 176% ROI)
• Will Benson has hit the Runs Under in 14 of his last 15 games (+12.45 Units / 46% ROI)
• Ke’Bryan Hayes has hit the Hits Runs and RBIs Under in 13 of his last 15 games (+12.00 Units / 59% ROI)
• Ke’Bryan Hayes has hit the Hits Under in 12 of his last 15 games (+10.85 Units / 72% ROI)
• Ke’Bryan Hayes has hit the Total Bases Under in 12 of his last 15 games (+10.65 Units / 70% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 45 away games (+8.85 Units / 16% ROI)
• The San Francisco Giants have hit the Team Total Under in 13 of their last 19 games (+6.60 Units / 31% ROI)
• The San Francisco Giants have hit the Game Total Over in 23 of their last 45 away games (+5.35 Units / 11% ROI)
• The San Francisco Giants have covered the Run Line in 21 of their last 35 away games (+4.85 Units / 10% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 18 of their last 30 games (+3.70 Units / 10% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 14 games at home (+9.80 Units / 54% ROI)
• The Cincinnati Reds have hit the Game Total Under in 25 of their last 45 games at home (+8.30 Units / 17% ROI)
• The Cincinnati Reds have hit the Team Total Under in 11 of their last 14 games at home (+7.50 Units / 42% ROI)
• The Cincinnati Reds have hit the Moneyline in 23 of their last 40 games (+6.40 Units / 14% ROI)
• The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 18 of their last 30 games (+2.85 Units / 8% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 5-11 against the Run Line (-11.1 Units / -44.67% ROI).

• 6-11 when betting on the Moneyline for -5.2 Units / -28.81% ROI
• 7-7 when betting on the total runs Over for -0.6 Units / -3.22% ROI
• 7-7 when betting on the total runs Under for -0.75 Units / -4% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 10-7 against the Run Line (+0.35 Units / 1.34% ROI).

• 10-7 when betting on the Moneyline for +3.5 Units / 18.82% ROI
• 9-7 when betting on the total runs Over for +1.35 Units / 7.28% ROI
• 7-9 when betting on the total runs Under for -3 Units / -15.92% ROI

Giants Keys to the Game vs. the Reds

The Giants are just 0-8 (.000) when allowing 5 or more runs this season — tied for lowest in MLB; League Avg: .235.

The Giants were just 65-6 (.915) when leading entering the 9th inning in the 2025 season — 3rd lowest in MLB; League Avg: .956.

The Giants are just 0-10 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .101.

The Giants are just 0-11 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .034.

Reds Keys to the Game vs. the Giants

The Reds are 1-7 (.125) when trailing entering the 9th inning this season — tied for 3rd best in MLB; League Avg: .034.

The Reds are just 14-27 (.341) when tied entering the 8th inning since the 2024 season — 2nd lowest in MLB; League Avg: .500.

The Reds are just 6-66 (.083) when trailing entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .124.

The Reds are just 9-131 (.064) when trailing entering the 8th inning since the 2024 season — 3rd lowest in MLB; League Avg: .095.

Giants Hitting Stats & Trends

Giants hitters had an OPS of just .631 (1,623 PA’s) against LHP in the 2025 season — lowest in MLB.

Giants hitters have drawn walks in 6% of their PA’s against RHP this season — lowest in MLB.

Giants hitters have an OBP of just .283 (1,803 PA’s) against LHP since the 2025 season — lowest in MLB.

Giants hitters had an OBP of just .280 (1,623 PA’s) against LHP in the 2025 season — lowest in MLB.

Reds Hitting Stats & Trends

The Reds are batting just .182 at home this season — lowest in MLB.

The Reds are batting just .156 with two outs this season — lowest in MLB.

Reds hitters have a swing rate of just 39% in lefty-lefty matchups since the 2025 season — lowest in MLB.

Reds hitters have an OPS of just .551 (282 PA’s) with runners on base this season — lowest in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 48% against Giants pitchers since the 2023 season — highest in MLB.

Opponents have a groundball rate of 48% against Giants pitchers this season — 3rd highest in MLB.

Opponents had a groundball rate of 46% against Giants pitchers in the 2025 season — 3rd highest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 57% of opposing batters this season — lowest in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a strikeout rate of just 20% this season — tied for 5th lowest in MLB.

Opponents have a groundball rate of just 40% against Reds pitchers since the 2025 season — 3rd lowest in MLB.

Opponents had a groundball rate of just 40% against Reds pitchers in the 2025 season — tied for 3rd lowest in MLB.

Reds pitchers have a first-pitch strike rate of just 57% this season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Giants vs Reds and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.