• The Giants are -120 favorites vs the Royals
• Giants vs Royals Over / Under today: 9 Runs
• Giants / Royals TV Channel: NSBA | RYTV

The San Francisco Giants (-120) visit Kauffman Stadium to take on the Kansas City Royals (+100) on July 22, 2026. First pitch is scheduled for 2:10 pm in Kansas City, MO.

This season, the Giants are 42-59 against the spread (ATS), while the Royals are 43-55 ATS.

Giants vs Royals Starting Pitchers Today:

• Giants starting pitcher: Landen Roupp 7-8, 4.01 ERA
• Royals starting pitcher: Seth Lugo 3-6, 4.40 ERA

Giants vs. Royals Odds, Run Line, Over/Under & Moneyline

Giants vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Royals will win Wednesday‘s MLB game with 54.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Giants vs Royals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

• Willy Adames has hit the Home Runs Over in 4 of his last 9 games (+14.80 Units / 164% ROI)
• Willy Adames has hit the Singles Under in 19 of his last 25 away games (+10.70 Units / 28% ROI)
• Willy Adames has hit the Runs Over in 12 of his last 20 away games (+8.95 Units / 43% ROI)
• Jung Hoo Lee has hit the Hits Under in 13 of his last 20 games (+7.75 Units / 25% ROI)
• Bryce Eldridge has hit the Walks Over in 13 of his last 25 games (+7.25 Units / 29% ROI)

And here are some favorite MLB player prop bets for Royals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

• Tyler Tolbert has hit the Home Runs Over in 2 of his last 6 games (+18.50 Units / 308% ROI)
• Starling Marte has hit the Hits Over in 19 of his last 20 games at home (+17.05 Units / 47% ROI)
• Starling Marte has hit the Singles Over in 19 of his last 25 games (+13.25 Units / 50% ROI)
• Starling Marte has hit the Total Bases Over in 15 of his last 20 games at home (+12.25 Units / 46% ROI)
• Seth Lugo has hit the Walks Allowed Over in 12 of his last 15 games at home (+7.95 Units / 36% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Under in 32 of their last 50 away games (+12.65 Units / 22% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games (+6.55 Units / 13% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 14 of their last 21 away games (+5.40 Units / 21% ROI)
• The San Francisco Giants have hit the Game Total Over in 15 of their last 30 away games (+5.10 Units / 15% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 5 of their last 7 away games (+4.50 Units / 57% ROI)

Royals Best Bets Today:

• The Kansas City Royals have hit the Team Total Under in 16 of their last 22 games (+9.20 Units / 36% ROI)
• The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 21 games (+6.40 Units / 25% ROI)
• The Kansas City Royals have hit the Moneyline in 6 of their last 7 games at home (+5.85 Units / 78% ROI)
• The Kansas City Royals have covered the Run Line in 5 of their last 7 games at home (+4.20 Units / 46% ROI)
• The Kansas City Royals have hit the Game Total Under in 7 of their last 10 games at home (+3.70 Units / 33% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 46-53 against the Run Line (-19.6 Units / -14.09% ROI).

• 42-59 when betting on the Moneyline for -15.8 Units / -14.03% ROI
• 45-46 when betting on the total runs Over for -5.85 Units / -5.24% ROI
• 46-45 when betting on the total runs Under for -3.4 Units / -3.08% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 43-55 against the Run Line (-27.05 Units / -18.97% ROI).

• 42-60 when betting on the Moneyline for -20.15 Units / -17.68% ROI
• 49-52 when betting on the total runs Over for -7.85 Units / -6.99% ROI
• 52-49 when betting on the total runs Under for -1.5 Units / -1.34% ROI

Royals vs Giants Home Run Prop Bets Today

Royals vs Giants Total Hits Prop Bets Today

Royals vs Giants Strikeout Prop Bets Today

Giants Keys to the Game vs. the Royals

The Giants are just 1-43 (.023) when trailing entering the 7th inning this season — lowest in MLB; League Avg: .134.

The Giants are just 7-14 (.333) vs bottom 10 scoring offenses this season Today, they face the Royals (21st in runs scored).

The Giants are just 32-10 (.762) when leading entering the 7th inning this season — 2nd lowest in MLB; League Avg: .866.

The Giants are just 1-47 (.021) when trailing entering the 8th inning this season — 2nd lowest in MLB; League Avg: .097.

Royals Keys to the Game vs. the Giants

The Royals are just 34-6 (.850) when leading entering the 9th inning this season — 2nd lowest in MLB; League Avg: .947.

The Royals are just 20-40 (.333) after a loss this season — lowest in MLB; League Avg: .486.

The Royals are just 5-36 (.122) when allowing 10 or more hits this season — 2nd lowest in MLB; League Avg: .247.

The Royals are just 42-60 (.412) this season — 3rd lowest in MLB; League Avg: .500.

Giants Hitting Stats & Trends

The Giants are batting .259 on the road this season — 2nd best in MLB.

Giants hitters have drawn walks in 7% of their PA’s this season — lowest in MLB.

Giants hitters have drawn walks in 7% of their PA’s against LHP this season — lowest in MLB.

The Giants are batting .183 with two-strikes this season — 2nd best in MLB.

Royals Hitting Stats & Trends

Royals hitters are slugging just .379 with runners on base this season — lowest in MLB.

Royals hitters have put 40% of their swings in play against LHP this season — 3rd highest in MLB.

Royals hitters are slugging just .234 with two-strikes this season — 3rd lowest in MLB.

The Royals have a winning percentage of just 34% on the road this season — 3rd lowest in MLB.

Giants Pitching Stats & Trends

Giants pitchers have thrown at least two strikes in their first three pitches to 58% of opposing batters this season — lowest in MLB.

Opponents have a miss rate of just 23% against Giants pitchers this season — 5th lowest in MLB.

Giants pitchers have won only 16% of games in which they have allowed their opponent to score in three different innings this season — tied for lowest in MLB.

Giants pitchers have a strikeout rate of just 20% this season — 5th lowest in MLB.

Royals Pitching Stats & Trends

Royals pitchers have walked 10% of batters this season — tied for 4th highest in MLB.

Royals pitchers have a strikeout rate of just 18% in late innings this season — lowest in MLB.

Royals pitchers have a strikeout rate of just 20% this season — 4th lowest in MLB.

Royals pitchers have a strikeout rate of just 38% with two-strikes this season — 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Giants vs Royals and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.