• The Astros are -140 favorites vs the Guardians
• Guardians vs Astros Over / Under today: 8.5 Runs
• Guardians / Astros TV Channel: GDTV | SCHN

The Cleveland Guardians (+115) visit Daikin Park to take on the Houston Astros (-140) on June 21, 2026. First pitch is scheduled for 2:10 pm in Houston, TX.

This season, the Guardians are 41-36 against the spread (ATS), while the Astros are 37-41 ATS.

Guardians vs Astros Starting Pitchers Today:

• Guardians starting pitcher: Slade Cecconi 3-5, 4.64 ERA
• Astros starting pitcher: Kai-Wei Teng 3-6, 4.31 ERA

Guardians vs. Astros Odds, Run Line, Over/Under & Moneyline

Guardians vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Sunday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Travis Bazzana has hit the Home Runs Over in 3 of his last 8 away games (+16.30 Units / 204% ROI)
• Rhys Hoskins has hit the Singles Under in 18 of his last 20 away games (+13.75 Units / 34% ROI)
• Rhys Hoskins has hit the Runs Under in 13 of his last 15 away games (+9.25 Units / 32% ROI)
• Steven Kwan has hit the Total Bases Under in 16 of his last 25 games (+9.20 Units / 32% ROI)
• Steven Kwan has hit the Hits Under in 13 of his last 20 away games (+8.60 Units / 36% ROI)

And here are some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Jose Altuve has hit the Home Runs Over in 4 of his last 8 games at home (+19.10 Units / 239% ROI)
• Jose Altuve has hit the Runs Over in 16 of his last 25 games at home (+9.85 Units / 38% ROI)
• Cam Smith has hit the Hits Under in 16 of his last 25 games at home (+9.65 Units / 38% ROI)
• Isaac Paredes has hit the Total Bases Over in 9 of his last 10 games at home (+9.30 Units / 68% ROI)
• Isaac Paredes has hit the Singles Under in 16 of his last 20 games (+9.00 Units / 29% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 30 of their last 50 away games (+16.35 Units / 31% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 34 of their last 50 away games (+16.05 Units / 26% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 away games (+15.15 Units / 28% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 45 games (+8.45 Units / 15% ROI)
• The Cleveland Guardians have hit the Team Total Under in 15 of their last 23 away games (+6.10 Units / 24% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 31 of their last 50 games at home (+11.90 Units / 21% ROI)
• The Houston Astros have hit the Team Total Over in 16 of their last 25 games (+6.95 Units / 25% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 30 games (+6.15 Units / 19% ROI)
• The Houston Astros have hit the Moneyline in 20 of their last 35 games (+5.80 Units / 15% ROI)
• The Houston Astros have covered the Run Line in 18 of their last 30 games (+4.25 Units / 10% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 38-38 against the Run Line (-2.6 Units / -2.6% ROI).

• 41-36 when betting on the Moneyline for +4.7 Units / 5.14% ROI
• 38-39 when betting on the total runs Over for -4.55 Units / -5.4% ROI
• 39-38 when betting on the total runs Under for -3.15 Units / -3.69% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 37-41 against the Run Line (-10.2 Units / -9.67% ROI).

• 36-42 when betting on the Moneyline for -7.6 Units / -8.46% ROI
• 42-32 when betting on the total runs Over for +5.85 Units / 6.7% ROI
• 32-42 when betting on the total runs Under for -13.9 Units / -16.47% ROI

Astros vs Guardians Home Run Prop Bets Today

Astros vs Guardians Total Hits Prop Bets Today

Astros vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the Astros

The Guardians are 13-2 (.867) when they’ve hit 2 or more home runs this season — 2nd best in MLB; League Avg: .703.

The Guardians are just 1-27 (.036) when trailing entering the 7th inning this season — 3rd lowest in MLB; League Avg: .138.

The Guardians are 47-7 (.855) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .745.

The Guardians are 96-8 (.923) when leading entering the 7th inning since the 2025 season — 2nd best in MLB; League Avg: .871.

Astros Keys to the Game vs. the Guardians

The Astros are 33-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB; League Avg: .945.

The Astros are just 7-20 (.259) when their opponents score in the first inning this season — 5th lowest in MLB; League Avg: .355.

The Astros are 6-3 (.667) when tied entering the 7th inning this season — tied for 4th best in MLB; League Avg: .500.

The Astros are 5-1 (.833) when tied entering the 8th inning this season — tied for best in MLB; League Avg: .500.

Guardians Hitting Stats & Trends

The Guardians are hitting just .165 against pitchers who have thrown at least 80 pitches in the game this season — lowest in MLB.

The Guardians are batting just .205 when facing the starting pitcher for the 3rd time in a game this season — tied for lowest in MLB.

The Guardians are batting just .221 on the road this season — 2nd lowest in MLB.

9% of Guardians’ hitters plate appearances have lasted only one pitch (271/2,878 PA’s) this season — 2nd lowest in MLB.

Astros Hitting Stats & Trends

Astros hitters have struck out in just 21% of their PA’s against LHP this season — tied for 5th best in MLB.

Astros hitters have drawn walks in 8% of their PA’s against LHP this season — 4th lowest in MLB.

Astros hitters have an OBP of just .237 (1,557 PA’s) with two-strikes this season — 5th lowest in MLB.

Astros hitters have struck out in just 17% of their PA’s in lefty-lefty matchups this season — 2nd best in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 32% in close and late situations this season — best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — 2nd best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 3rd best in MLB.

Guardians pitchers have a strikeout rate of 25% with runners in scoring position this season — 3rd best in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 12% of batters this season — tied for 2nd highest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a groundball rate of just 40% against Astros pitchers this season — tied for 2nd lowest in MLB.

The Astros have allowed 3.23 runs per game (252/78) in the first 5 innings this season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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