• The Guardians are -118 favorites vs the Cardinals
• Guardians vs Cardinals Over / Under today: 8 Runs
• Guardians / Cardinals TV Channel: GDTV | CATV

The Cleveland Guardians (-118) visit Busch Stadium to take on the St. Louis Cardinals (-102) on April 13, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Guardians are 9-7 against the spread (ATS), while the Cardinals are 7-7 ATS.

Guardians vs Cardinals Starting Pitchers Today:

• Guardians starting pitcher: Gavin Williams 1-1, 2.04 ERA
• Cardinals starting pitcher: Matthew Liberatore 0-0, 3.38 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 52.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Gavin Williams has hit the Hits Allowed Under in 20 of his last 25 games (+14.00 Units / 46% ROI)
• Chase DeLauter has hit the Home Runs Over in 3 of his last 9 away games (+12.00 Units / 133% ROI)
• Gavin Williams has hit the Walks Allowed Over in 17 of his last 25 games (+9.90 Units / 32% ROI)
• Steven Kwan has hit the Hits Under in 14 of his last 25 games (+7.90 Units / 24% ROI)
• Gavin Williams has hit the Strikeouts Over in his last 7 games (+7.45 Units / 90% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Jordan Walker has hit the Home Runs Over in 6 of his last 8 games (+32.70 Units / 409% ROI)
• Jordan Walker has hit the Runs Over in 13 of his last 20 games (+12.95 Units / 65% ROI)
• Masyn Winn has hit the Total Bases Under in 18 of his last 25 games at home (+9.85 Units / 25% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 14 of his last 20 games (+9.15 Units / 42% ROI)
• Jordan Walker has hit the Hits Over in his last 8 games (+8.00 Units / 50% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 33 of their last 50 games (+21.20 Units / 37% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 away games (+11.90 Units / 20% ROI)
• The Cleveland Guardians have covered the Run Line in 28 of their last 45 games (+11.55 Units / 19% ROI)
• The Cleveland Guardians have hit the Game Total Under in 25 of their last 40 games (+10.60 Units / 24% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 18 games (+9.10 Units / 42% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 40 games at home (+8.55 Units / 18% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 25 of their last 40 games at home (+8.45 Units / 18% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 23 of their last 40 games at home (+5.30 Units / 12% ROI)
• The St. Louis Cardinals have hit the Moneyline in 12 of their last 20 games at home (+4.85 Units / 23% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 8 of their last 12 games at home (+3.00 Units / 19% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 9-7 against the Run Line (+0.15 Units / 0.68% ROI).

• 9-7 when betting on the Moneyline for +5.2 Units / 31.52% ROI
• 7-9 when betting on the total runs Over for -2.8 Units / -15.95% ROI
• 9-7 when betting on the total runs Under for +1.15 Units / 6.48% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 7-7 against the Run Line (-2.65 Units / -12.59% ROI).

• 8-7 when betting on the Moneyline for +2.05 Units / 13.23% ROI
• 8-6 when betting on the total runs Over for +1.5 Units / 9.26% ROI
• 6-8 when betting on the total runs Under for -3.1 Units / -18.34% ROI

Guardians Keys to the Game vs. the Cardinals

The Guardians are 35-4 (.875) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .749.

The Guardians are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .024.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians were 24-2 (.923) when they had 5 or more XBH in the 2025 season — 2nd best in MLB; League Avg: .799.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .024.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are just 8-12 (.400) when tied entering the 8th inning since the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 133-8 (.943) when leading entering the 8th inning since the 2024 season — 3rd best in MLB; League Avg: .904.

Guardians Hitting Stats & Trends

The Guardians batted just .186 in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters had an OPS of just .545 (690 PA’s) in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters slugged just .295 in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters have struck out in 32% of their PA’s in righty-righty matchups since the 2025 season — highest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Cardinals hitters slugged just .489 when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Cardinals hitters are slugging just .484 with the pitcher behind in the count since the 2025 season — lowest in MLB.

The Cardinals are batting just .157 with two outs this season — lowest in MLB.

Guardians Pitching Stats & Trends

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Guardians pitchers have an ERA of 2.51 (498.1 IP) against division opponents since the 2025 season — best in MLB.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Guardians pitchers had an ERA of 3.72 (706.0 IP) on the road in the 2025 season — tied for best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2025 season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 32% with two-strikes this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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