• The Guardians are -120 favorites vs the Cardinals
• Guardians vs Cardinals Over / Under today: 8.5 Runs
• Guardians / Cardinals TV Channel: GDTV | CATV

The Cleveland Guardians (-120) visit Busch Stadium to take on the St. Louis Cardinals (+100) on April 14, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Guardians are 10-7 against the spread (ATS), while the Cardinals are 7-8 ATS.

Guardians vs Cardinals Starting Pitchers Today:

• Guardians starting pitcher: Joey Cantillo 1-0, 2.46 ERA
• Cardinals starting pitcher: Michael McGreevy 1-1, 2.21 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 52.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 2 of his last 7 games (+17.00 Units / 243% ROI)
• Bo Naylor has hit the Hits Runs and RBIs Under in 8 of his last 10 games (+6.90 Units / 58% ROI)
• Kyle Manzardo has hit the Total Bases Under in 16 of his last 25 games (+6.85 Units / 23% ROI)
• Steven Kwan has hit the Hits Over in 6 of his last 7 games (+6.65 Units / 55% ROI)
• Chase DeLauter has hit the Walks Over in 4 of his last 5 games (+6.60 Units / 132% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Jordan Walker has hit the Home Runs Over in 7 of his last 9 games (+37.10 Units / 412% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+12.75 Units / 51% ROI)
• Ivan Herrera has hit the Walks Over in 10 of his last 15 games (+10.10 Units / 67% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.10 Units / 36% ROI)
• Jordan Walker has hit the RBIs Over in 6 of his last 7 games (+9.15 Units / 131% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 31 of their last 45 games (+21.35 Units / 41% ROI)
• The Cleveland Guardians have covered the Run Line in 29 of their last 45 games (+13.95 Units / 23% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 27 of their last 40 away games (+11.90 Units / 24% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 19 of their last 35 away games (+9.45 Units / 26% ROI)
• The Cleveland Guardians have hit the Game Total Under in 27 of their last 45 games (+9.30 Units / 19% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+10.70 Units / 23% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 25 of their last 40 games at home (+8.40 Units / 18% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 13 of their last 22 games (+4.30 Units / 18% ROI)
• The St. Louis Cardinals have hit the Moneyline in 12 of their last 21 games at home (+3.85 Units / 18% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 8 of their last 13 games at home (+1.55 Units / 9% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 10-7 against the Run Line (+1.55 Units / 6.7% ROI).

• 10-7 when betting on the Moneyline for +6.2 Units / 35.03% ROI
• 8-9 when betting on the total runs Over for -1.8 Units / -9.65% ROI
• 9-8 when betting on the total runs Under for +0.05 Units / 0.27% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 7-8 against the Run Line (-4.3 Units / -18.94% ROI).

• 8-8 when betting on the Moneyline for +1.05 Units / 6.36% ROI
• 9-6 when betting on the total runs Over for +2.5 Units / 14.45% ROI
• 6-9 when betting on the total runs Under for -4.2 Units / -23.33% ROI

Guardians Keys to the Game vs. the Cardinals

The Guardians are just 2-7 (.222) after a win this season — 2nd lowest in MLB; League Avg: .528.

The Guardians are 34-17 (.667) when tied entering the 7th inning since the 2024 season — best in MLB; League Avg: .499.

The Guardians were 34-12 (.723) when they scored in the first inning in the 2025 season — 5th best in MLB; League Avg: .636.

The Guardians are 36-4 (.878) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .748.

Cardinals Keys to the Game vs. the Guardians

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are just 0-8 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .027.

The Cardinals are just 8-12 (.400) when tied entering the 8th inning since the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 133-8 (.943) when leading entering the 8th inning since the 2024 season — tied for 3rd best in MLB; League Avg: .904.

Guardians Hitting Stats & Trends

The Guardians batted just .186 in righty-righty matchups in the 2025 season — lowest in MLB.

7% of Guardians’ hitters plate appearances have lasted only one pitch (43/627 PA’s) this season — lowest in MLB.

The Guardians are batting just .192 in righty-righty matchups since the 2025 season — lowest in MLB.

Guardians hitters had an OPS of just .545 (690 PA’s) in righty-righty matchups in the 2025 season — lowest in MLB.

Cardinals Hitting Stats & Trends

The Cardinals are batting just .159 with two outs this season — lowest in MLB.

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

The Cardinals are batting just .215 with two outs since the 2025 season — lowest in MLB.

Cardinals hitters pulled just 43% of balls they’ve put into play against RHP in the 2025 season — lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers had an ERA of 3.72 (706.0 IP) on the road in the 2025 season — tied for best in MLB.

Guardians pitchers have a strikeout rate of 40% in close and late situations this season — best in MLB.

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 32% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 14% in the first 5 innings this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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