• The Guardians are -115 favorites vs the White Sox
• Guardians vs White Sox Over / Under today: 7 Runs
• Guardians / White Sox TV Channel: GDTV | CHSN

The Cleveland Guardians (-115) visit Rate Field to take on the Chicago White Sox (-105) on June 23, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Guardians are 41-38 against the spread (ATS), while the White Sox are 43-32 ATS.

Guardians vs White Sox Starting Pitchers Today:

• Guardians starting pitcher: Parker Messick 7-3, 2.73 ERA
• White Sox starting pitcher: Sean Burke 4-4, 3.89 ERA

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Tuesday‘s MLB game with 52.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Travis Bazzana has hit the Home Runs Over in 3 of his last 10 away games (+14.30 Units / 143% ROI)
• Rhys Hoskins has hit the Singles Under in 17 of his last 20 away games (+10.45 Units / 26% ROI)
• Steven Kwan has hit the Total Bases Under in 17 of his last 25 away games (+10.20 Units / 34% ROI)
• Steven Kwan has hit the Hits Under in 15 of his last 25 games (+9.70 Units / 39% ROI)
• Rhys Hoskins has hit the Runs Under in 13 of his last 15 away games (+9.25 Units / 32% ROI)

And here are some favorite MLB player prop bets for White Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Sam Antonacci has hit the Home Runs Over in 3 of his last 7 games (+25.00 Units / 357% ROI)
• Drew Romo has hit the Singles Under in 21 of his last 25 games (+13.55 Units / 30% ROI)
• Miguel Vargas has hit the Runs Over in 17 of his last 25 games at home (+11.30 Units / 45% ROI)
• Chase Meidroth has hit the Hits Over in 20 of his last 25 games (+11.25 Units / 23% ROI)
• Tristan Peters has hit the Hits Runs and RBIs Over in 15 of his last 20 games (+10.00 Units / 39% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 33 of their last 50 away games (+13.80 Units / 23% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 away games (+12.75 Units / 24% ROI)
• The Cleveland Guardians have hit the Moneyline in 28 of their last 50 away games (+11.60 Units / 22% ROI)
• The Cleveland Guardians have hit the Team Total Under in 19 of their last 30 games (+7.20 Units / 21% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 14 of their last 22 games (+4.50 Units / 16% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Moneyline in 21 of their last 25 games at home (+19.10 Units / 71% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 40 games (+15.45 Units / 32% ROI)
• The Chicago White Sox have covered the Run Line in 20 of their last 25 games at home (+13.50 Units / 37% ROI)
• The Chicago White Sox have hit the Team Total Over in 27 of their last 40 games (+12.75 Units / 27% ROI)
• The Chicago White Sox have hit the Game Total Over in 25 of their last 40 games (+10.70 Units / 25% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 39-39 against the Run Line (-2.6 Units / -2.53% ROI).

• 41-38 when betting on the Moneyline for +2.6 Units / 2.78% ROI
• 39-40 when betting on the total runs Over for -4.65 Units / -5.39% ROI
• 40-39 when betting on the total runs Under for -3.35 Units / -3.82% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 43-32 against the Run Line (-1.05 Units / -0.94% ROI).

• 40-37 when betting on the Moneyline for +9.75 Units / 12.07% ROI
• 45-30 when betting on the total runs Over for +12.15 Units / 14.44% ROI
• 30-45 when betting on the total runs Under for -19.95 Units / -23.4% ROI

White Sox vs Guardians Home Run Prop Bets Today

White Sox vs Guardians Total Hits Prop Bets Today

White Sox vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the White Sox

The Guardians are just 1-29 (.033) when trailing entering the 7th inning this season — 2nd lowest in MLB; League Avg: .139.

The Guardians are 13-2 (.867) when they’ve hit 2 or more home runs this season — 2nd best in MLB; League Avg: .706.

The Guardians are 22-15 (.595) after a loss this season — 3rd best in MLB; League Avg: .489.

The Guardians are 30-3 (.909) when leading entering the 7th inning this season — tied for 5th best in MLB; League Avg: .861.

White Sox Keys to the Game vs. the Guardians

The White Sox are 25-12 (.676) at home this season — 2nd best in MLB; League Avg: .533.

The White Sox are 6-3 (.667) when tied entering the 7th inning this season — 4th best in MLB; League Avg: .500.

The White Sox are 7-29 (.194) when trailing entering the 7th inning this season — tied for 3rd best in MLB; League Avg: .139.

The White Sox are just 3-19 (.136) when allowing 10 or more hits this season — tied for 4th lowest in MLB; League Avg: .245.

Guardians Hitting Stats & Trends

The Guardians are hitting just .161 against pitchers who have thrown at least 80 pitches in the game this season — lowest in MLB.

The Guardians are batting just .197 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Guardians hitters have an OBP of just .275 (333 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Guardians are batting just .221 against starting pitchers this season — 2nd lowest in MLB.

White Sox Hitting Stats & Trends

White Sox hitters are slugging .623 on the first pitch of at-bats this season — 4th best in MLB.

White Sox hitters have struck out in 24% of their PA’s against RHP this season — 3rd highest in MLB.

White Sox hitters are slugging .438 against LHP this season — 4th best in MLB.

White Sox hitters have struck out in 24% of their PA’s this season — 3rd highest in MLB.

Guardians Pitching Stats & Trends

Opponents have a miss rate of 28% against Guardians pitchers this season — tied for 2nd best in MLB.

Guardians pitchers have a strikeout rate of 32% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 3rd best in MLB.

Guardians pitchers have an ERA of 2.75 (153.2 IP) against division opponents this season — 2nd best in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

White Sox pitchers have walked 10% of batters this season — tied for 4th highest in MLB.

White Sox pitchers have an ERA of 5.39 (338.2 IP) on the road this season — 2nd highest in MLB.

Opponents have a groundball rate of just 40% against White Sox pitchers this season — tied for 5th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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