• The Mariners are -125 favorites vs the Astros
• Mariners vs Astros Over / Under today: 9 Runs
• Mariners / Astros TV Channel: MRTV | SCHN

The Seattle Mariners (-125) visit Daikin Park to take on the Houston Astros (+105) on May 13, 2026. First pitch is scheduled for 8:10 pm in Houston, TX.

This season, the Mariners are against the spread (ATS), while the Astros are ATS.

Mariners vs Astros Starting Pitchers Today:

• Mariners starting pitcher: Bryce Miller 0-0, 0.00 ERA
• Astros starting pitcher: Lance McCullers 2-3, 7.35 ERA

Mariners vs. Astros Odds, Run Line, Over/Under & Moneyline

Mariners vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Wednesday‘s MLB game with 52.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Mariners vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Mariners players for Wednesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

• Josh Naylor has hit the Home Runs Over in 3 of his last 10 away games (+11.60 Units / 116% ROI)
• Cal Raleigh has hit the Hits Under in 9 of his last 10 games (+11.10 Units / 111% ROI)
• Randy Arozarena has hit the Singles Over in 17 of his last 25 away games (+10.50 Units / 40% ROI)
• Cole Young has hit the Walks Under in 17 of his last 20 games (+10.50 Units / 22% ROI)
• Cole Young has hit the Runs Under in his last 10 games (+10.00 Units / 48% ROI)

And here are some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Braden Shewmake has hit the Home Runs Over in 2 of his last 5 games (+16.00 Units / 320% ROI)
• Jose Altuve has hit the Runs Over in 12 of his last 15 games at home (+10.45 Units / 66% ROI)
• Cam Smith has hit the Hits Under in 9 of his last 10 games at home (+10.05 Units / 100% ROI)
• Yordan Alvarez has hit the RBIs Under in 13 of his last 15 games (+9.80 Units / 37% ROI)
• Cam Smith has hit the Total Bases Under in 12 of his last 15 games at home (+9.75 Units / 50% ROI)

Mariners Best Bets Today:

• The Seattle Mariners have hit the Team Total Under in 17 of their last 25 away games (+7.40 Units / 25% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 19 games (+6.05 Units / 25% ROI)
• The Seattle Mariners have hit the Game Total Under in 13 of their last 21 away games (+5.50 Units / 24% ROI)
• The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in 5 of their last 6 games (+4.05 Units / 61% ROI)
• The Seattle Mariners have hit the Moneyline in 8 of their last 11 away games (+4.05 Units / 26% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 21 of their last 30 games at home (+11.90 Units / 35% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 27 of their last 45 games (+8.15 Units / 16% ROI)
• The Houston Astros have hit the Team Total Under in 10 of their last 12 games (+7.25 Units / 48% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Astros vs Mariners Home Run Prop Bets Today

Astros vs Mariners Total Hits Prop Bets Today

Astros vs Mariners Strikeout Prop Bets Today

Mariners Keys to the Game vs. the Astros

The Mariners are 9-3 (.750) vs top 10 scoring offenses this season Today, they face the Astros (ninth in runs scored).

The Mariners are 15-5 (.750) vs the bottom 10 runs allowed teams this season Today, they face the Astros (29th runs allowed).

The Mariners are 6-78 (.071) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB; League Avg: .044.

The Mariners are 23-14 (.622) when tied entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .500.

Astros Keys to the Game vs. the Mariners

The Astros are just 16-24 (.400) when allowing 5 or more extra base hits this season — tied for lowest in MLB; League Avg: .532.

The Astros are just 4-20 (.167) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .278.

The Astros are just 0-23 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .136.

The Astros are just 0-25 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .103.

Mariners Hitting Stats & Trends

Mariners hitters have an OBP of just .280 (477 PA’s) against LHP this season — 2nd lowest in MLB.

The Mariners are batting just .200 against LHP this season — tied for 2nd lowest in MLB.

The Mariners are batting just .147 with two-strikes this season — 3rd lowest in MLB.

Mariners hitters have an OPS of just .645 (719 PA’s) on the road this season — 5th lowest in MLB.

Astros Hitting Stats & Trends

The Astros are batting .344 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Astros hitters have an OBP of .418 (177 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .278 on the road this season — 2nd best in MLB.

Astros hitters have an OPS of .784 (870 PA’s) on the road this season — 3rd best in MLB.

Mariners Pitching Stats & Trends

Mariners pitchers have a first-pitch strike rate of 67% this season — highest in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 70% of opposing batters this season — highest in MLB.

Mariners pitchers have walked 7% of batters this season — best in MLB.

Mariners pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — tied for 2nd best in MLB.

Astros Pitching Stats & Trends

The Astros have allowed 3.64 runs per game (153/42) in the first 5 innings this season — highest in MLB.

Astros pitchers have walked 13% of batters this season — highest in MLB.

Astros pitchers have an ERA of 5.50 (366.1 IP) this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — tied for lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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