• The Cardinals are -135 favorites vs the Nationals
• Nationals vs Cardinals Over / Under today: 8.5 Runs
• Nationals / Cardinals TV Channel: CATV | NATV

The Washington Nationals (+110) visit Busch Stadium to take on the St. Louis Cardinals (-135) on September 19, 2026. First pitch is scheduled for 7:15 pm in St. Louis, MO.

This season, the Nationals are 72-82 against the spread (ATS), while the Cardinals are 83-68 ATS.

Nationals vs Cardinals Starting Pitchers Today:

• Nationals starting pitcher: Andrew Alvarez 2-6, 3.37 ERA
• Cardinals starting pitcher: Michael McGreevy 7-9, 3.86 ERA

Nationals vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Nationals vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Saturday‘s MLB game with 54.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Nationals vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Nationals players for Saturday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Bets Today:

• Keibert Ruiz has hit the Home Runs Over in 2 of his last 5 away games (+15.00 Units / 300% ROI)
• Daylen Lile has hit the Hits Under in 16 of his last 25 away games (+11.90 Units / 38% ROI)
• Keibert Ruiz has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+11.50 Units / 41% ROI)
• James Wood has hit the Runs Under in 17 of his last 25 games (+9.85 Units / 35% ROI)
• Daylen Lile has hit the Total Bases Under in 18 of his last 25 away games (+9.75 Units / 27% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Nathan Church has hit the Hits Over in 21 of his last 25 games (+14.55 Units / 35% ROI)
• Nathan Church has hit the Singles Over in 18 of his last 25 games (+11.95 Units / 45% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.95 Units / 39% ROI)
• Alec Burleson has hit the RBIs Over in 14 of his last 25 games (+10.25 Units / 41% ROI)
• Leonardo Bernal has hit the Home Runs Over in 2 of his last 8 games (+9.00 Units / 112% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the Team Total Over in 13 of their last 19 games (+6.80 Units / 31% ROI)
• The Washington Nationals have hit the Game Total Over in 12 of their last 18 games (+6.55 Units / 33% ROI)
• The Washington Nationals have hit the Moneyline in 5 of their last 6 games (+4.85 Units / 66% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 12 of their last 19 games (+4.30 Units / 20% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 9 of their last 19 games (+3.40 Units / 15% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 27 of their last 40 games (+14.75 Units / 33% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 24 of their last 45 games (+9.35 Units / 18% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 27 of their last 45 games at home (+8.10 Units / 16% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+7.95 Units / 16% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 27 of their last 45 games (+5.90 Units / 11% ROI)

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 86-66 against the Run Line (+7.95 Units / 3.85% ROI).

• 72-82 when betting on the Moneyline for +0.6 Units / 0.36% ROI
• 81-65 when betting on the total runs Over for +10.2 Units / 6.02% ROI
• 65-81 when betting on the total runs Under for -23.75 Units / -14.01% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 83-68 against the Run Line (-0.4 Units / -0.19% ROI).

• 75-79 when betting on the Moneyline for +1.2 Units / 0.71% ROI
• 72-75 when betting on the total runs Over for -11.05 Units / -6.5% ROI
• 75-72 when betting on the total runs Under for -4.25 Units / -2.52% ROI

Nationals Keys to the Game vs. the Cardinals

The Nationals are just 1-71 (.014) when trailing entering the 9th inning this season — tied for lowest in MLB.

The Nationals are just 57-19 (.750) when leading entering the 7th inning this season — lowest in MLB.

The Nationals are just 35-26 (.574) when they’ve hit 2 or more home runs this season — 3rd lowest in MLB.

The Nationals are just 2-62 (.031) when trailing entering the 8th inning this season — 3rd lowest in MLB.

Cardinals Keys to the Game vs. the Nationals

The Cardinals are just 28-17 (.622) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 37-42 (.468) at home this season — 5th lowest in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — tied for 3rd lowest in MLB.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Nationals Hitting Stats & Trends

Nationals hitters have an OPS of .548 (3,091 PA’s) with two-strikes this season — best in MLB.

Nationals hitters are slugging .288 with two-strikes this season — 2nd best in MLB.

Nationals hitters are slugging .438 against LHP this season — tied for 2nd best in MLB.

Nationals hitters are slugging .248 on pitches out of the zone this season — 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have an OPS of just .660 (2,889 PA’s) at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .356 at home this season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .691 (4,087 PA’s) against RHP this season — 4th lowest in MLB.

Cardinals hitters have an OBP of .355 (679 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Nationals Pitching Stats & Trends

Nationals pitchers have an ERA of 5.03 (711.0 IP) at home this season — 3rd highest in MLB.

The Nationals have allowed 1.86 runs per game (287/154) in late innings this season — highest in MLB.

The Nationals have allowed 5.51 runs per game (430/78) at home this season — 3rd highest in MLB.

Nationals pitchers have a strikeout rate of just 20% this season — 5th lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 3rd highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 132 double plays in 1,161 opportunities (11%) this season — best in MLB.

Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Nationals vs Cardinals and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.