- The Cardinals are -145 favorites vs the Nationals
- Nationals vs Cardinals Over / Under today: 8.5 Runs
- Nationals / Cardinals TV Channel: CATV | NATV
The Washington Nationals (+120) visit Busch Stadium to take on the St. Louis Cardinals (-145) on September 20, 2026. First pitch is scheduled for 2:15 pm in St. Louis, MO.
This season, the Nationals are 73-82 against the spread (ATS), while the Cardinals are 83-69 ATS.
Nationals vs Cardinals Starting Pitchers Today:
- Nationals starting pitcher: Jake Irvin 2-9, 5.48 ERA
- Cardinals starting pitcher: Quinn Mathews 2-3, 3.65 ERA
Nationals vs. Cardinals Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Nationals | +1.5 -165 | O 8.5 -102 | +120 |
| Cardinals | -1.5 +135 | U 8.5 -118 | -145 |
Nationals vs Cardinals Prediction for Today’s Game
Based on recent trends the model predicts the Cardinals will win Sunday‘s MLB game with 55.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Nationals players for Sunday‘s game, looking at profitable historical betting trends:
Best Nationals Player Prop Bets Today:
- Keibert Ruiz has hit the Home Runs Over in 2 of his last 6 away games (+14.00 Units / 233% ROI)
- Daylen Lile has hit the Hits Under in 16 of his last 25 away games (+11.90 Units / 38% ROI)
- James Wood has hit the Runs Under in 17 of his last 25 games (+9.85 Units / 35% ROI)
- Brady House has hit the Total Bases Over in 17 of his last 25 games (+9.60 Units / 30% ROI)
- Keibert Ruiz has hit the Hits Runs and RBIs Over in 17 of his last 25 away games (+9.35 Units / 34% ROI)
And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today:
- Nathan Church has hit the Hits Over in 21 of his last 25 games (+14.55 Units / 34% ROI)
- JJ Wetherholt has hit the Total Bases Under in 20 of his last 25 games at home (+12.40 Units / 28% ROI)
- Nathan Church has hit the Singles Over in 18 of his last 25 games (+11.75 Units / 44% ROI)
- Nathan Church has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.85 Units / 39% ROI)
- Alec Burleson has hit the RBIs Over in 14 of his last 25 games (+10.25 Units / 41% ROI)
Nationals Best Bets Today:
- The Washington Nationals have hit the Team Total Over in 25 of their last 40 games (+9.10 Units / 20% ROI)
- The Washington Nationals have hit the Game Total Over in 13 of their last 19 games (+7.55 Units / 36% ROI)
- The Washington Nationals have hit the Moneyline in 6 of their last 7 games (+5.85 Units / 69% ROI)
- The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 13 of their last 20 games (+5.30 Units / 23% ROI)
- The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 10 of their last 20 games (+4.40 Units / 19% ROI)
Cardinals Best Bets Today:
- The St. Louis Cardinals have hit the Game Total Over in 28 of their last 40 games (+16.85 Units / 38% ROI)
- The St. Louis Cardinals have hit the Team Total Over in 26 of their last 40 games (+9.55 Units / 20% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+7.95 Units / 16% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 23 of their last 45 games (+6.70 Units / 13% ROI)
- The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 26 of their last 45 games (+3.90 Units / 7% ROI)
Nationals Against the Spread (ATS) Record
Against the spread this season, the Nationals are 87-66 against the Run Line (+9.5 Units / 4.58% ROI).
- 73-82 when betting on the Moneyline for +1.6 Units / 0.95% ROI
- 82-65 when betting on the total runs Over for +11.2 Units / 6.57% ROI
- 65-82 when betting on the total runs Under for -24.75 Units / -14.52% ROI
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 83-69 against the Run Line (-2.2 Units / -1.03% ROI).
- 75-80 when betting on the Moneyline for +0.1 Units / 0.06% ROI
- 73-75 when betting on the total runs Over for -10.05 Units / -5.87% ROI
- 75-73 when betting on the total runs Under for -5.25 Units / -3.09% ROI
Nationals Keys to the Game vs. the Cardinals
The Nationals are just 35-26 (.574) when they’ve hit 2 or more home runs this season — 3rd lowest in MLB.
The Nationals are just 58-19 (.753) when leading entering the 7th inning this season — lowest in MLB.
The Nationals are just 62-14 (.816) when leading entering the 8th inning this season — 3rd lowest in MLB.
The Nationals are just 1-71 (.014) when trailing entering the 9th inning this season — lowest in MLB.
Cardinals Keys to the Game vs. the Nationals
The Cardinals are just 28-18 (.609) when they’ve had 10 or more hits this season — 2nd lowest in MLB.
The Cardinals are just 37-43 (.462) at home this season — 5th lowest in MLB.
The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — tied for 3rd lowest in MLB.
The Cardinals are just 13-25 (.342) when tied entering the 8th inning since the 2025 season — 2nd lowest in MLB.
Nationals Hitting Stats & Trends
Nationals hitters have 349 extra-base hits out of 901 total hits (39%) against RHP this season — best in MLB.
Nationals hitters have an OPS of .547 (3,123 PA’s) with two-strikes this season — 2nd best in MLB.
The Nationals are batting .178 with two-strikes this season — tied for 3rd best in MLB.
Nationals hitters are slugging .287 with two-strikes this season — 2nd best in MLB.
Cardinals Hitting Stats & Trends
Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.
Cardinals hitters have an OBP of just .305 (2,938 PA’s) at home this season — 2nd lowest in MLB.
The Cardinals are batting .277 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.
Cardinals hitters have an OPS of just .661 (2,938 PA’s) at home this season — 2nd lowest in MLB.
Nationals Pitching Stats & Trends
Nationals pitchers have an ERA of 5.03 (711.0 IP) at home this season — 3rd highest in MLB.
Opponents have a miss rate of just 23% against Nationals pitchers this season — tied for 4th lowest in MLB.
Nationals pitchers have a strikeout rate of just 20% this season — 5th lowest in MLB.
The Nationals have allowed 1.87 runs per game (290/155) in late innings this season — highest in MLB.
Cardinals Pitching Stats & Trends
The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.
Cardinals pitchers have induced opposing hitters to ground into 132 double plays in 1,173 opportunities (11%) this season — tied for best in MLB.
Opponents have a groundball rate of 45% against Cardinals pitchers this season — 4th highest in MLB.
Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.
More MLB Reading:
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