• The Cardinals are -125 favorites vs the Orioles
• Orioles vs Cardinals Over / Under today: 8.5 Runs
• Orioles / Cardinals TV Channel: MASN | CATV

The Baltimore Orioles (+105) visit Busch Stadium to take on the St. Louis Cardinals (-125) on August 25, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Orioles are 63-68 against the spread (ATS), while the Cardinals are 71-58 ATS.

Orioles vs Cardinals Starting Pitchers Today:

• Orioles starting pitcher: Chris Bassitt 4-4, 5.11 ERA
• Cardinals starting pitcher: Matthew Liberatore 5-11, 5.06 ERA

Orioles vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Orioles vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Tuesday‘s MLB game with 56.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Orioles vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Orioles players for Tuesday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

• Christian Encarnacio has hit the Home Runs Over in 4 of his last 10 away games (+13.60 Units / 136% ROI)
• Gunnar Henderson has hit the Runs Over in 17 of his last 25 away games (+11.90 Units / 44% ROI)
• Pete Alonso has hit the Hits Over in 14 of his last 15 games (+11.40 Units / 35% ROI)
• Pete Alonso has hit the Total Bases Over in 12 of his last 15 games (+11.20 Units / 74% ROI)
• Pete Alonso has hit the Singles Over in 17 of his last 25 games (+10.65 Units / 42% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Blaze Jordan has hit the Runs Under in his last 20 games at home (+20.00 Units / 44% ROI)
• Jordan Walker has hit the Home Runs Over in 4 of his last 9 games (+12.00 Units / 133% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.90 Units / 38% ROI)
• JJ Wetherholt has hit the Hits Under in 15 of his last 25 games at home (+10.65 Units / 34% ROI)
• Jimmy Crooks III has hit the Singles Under in 13 of his last 15 games at home (+9.70 Units / 35% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have hit the Team Total Over in 23 of their last 35 away games (+10.45 Units / 26% ROI)
• The Baltimore Orioles have covered the Run Line in 21 of their last 30 away games (+10.05 Units / 23% ROI)
• The Baltimore Orioles have hit the Game Total Under in 27 of their last 45 games (+8.90 Units / 18% ROI)
• The Baltimore Orioles have hit the Moneyline in 17 of their last 30 away games (+7.60 Units / 24% ROI)
• The Baltimore Orioles have hit the 1st Five Innings (F5) Moneyline in 17 of their last 30 away games (+6.90 Units / 21% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 17 of their last 21 games (+12.60 Units / 52% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 15 of their last 23 games (+12.30 Units / 47% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 28 of their last 45 games at home (+10.65 Units / 22% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 20 of their last 30 games at home (+9.45 Units / 27% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 19 of their last 30 games at home (+6.30 Units / 17% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 68-62 against the Run Line (+0.95 Units / 0.55% ROI).

• 63-68 when betting on the Moneyline for -9.65 Units / -6.29% ROI
• 65-62 when betting on the total runs Over for -3.2 Units / -2.21% ROI
• 62-65 when betting on the total runs Under for -8.8 Units / -6.13% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 71-58 against the Run Line (-2.1 Units / -1.14% ROI).

• 66-66 when betting on the Moneyline for +5.8 Units / 4.05% ROI
• 56-70 when betting on the total runs Over for -21.35 Units / -14.68% ROI
• 70-56 when betting on the total runs Under for +8.2 Units / 5.65% ROI

Cardinals vs Orioles Home Run Prop Bets Today

Cardinals vs Orioles Total Hits Prop Bets Today

Cardinals vs Orioles Strikeout Prop Bets Today

Orioles Keys to the Game vs. the Cardinals

The Orioles are just 2-5 (.286) when tied entering the 8th inning this season — 2nd lowest in MLB.

The Orioles are just 4-9 (.308) when tied entering the 7th inning this season — 5th lowest in MLB.

The Orioles are just 13-21 (.382) when tied entering the 7th inning since the 2025 season — 3rd lowest in MLB.

The Orioles are just 20-75 (.211) when allowing 2 or more home runs since the 2025 season — 3rd lowest in MLB.

Cardinals Keys to the Game vs. the Orioles

The Cardinals are just 25-14 (.641) when they’ve had 10 or more hits this season — tied for 2nd lowest in MLB.

The Cardinals are just 5-46 (.098) when trailing entering the 7th inning this season — 5th lowest in MLB.

The Cardinals are just 12-114 (.095) when trailing entering the 7th inning since the 2025 season — 4th lowest in MLB.

The Cardinals are just 13-23 (.361) when tied entering the 8th inning since the 2025 season — 2nd lowest in MLB.

Orioles Hitting Stats & Trends

Orioles hitters are slugging just .183 on pitches out of the zone this season — 3rd lowest in MLB.

The Orioles are batting just .134 on pitches out of the zone this season — 3rd lowest in MLB.

Orioles hitters have an OPS of .775 (1,252 PA’s) on pitches 95 mph or greater this season — best in MLB.

Orioles hitters have a Hard-Hit Rate of 51% on pitches 95 mph or greater this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OPS of just .669 (2,411 PA’s) at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .499 with the pitcher behind in the count this season — lowest in MLB.

Cardinals hitters are slugging just .378 against RHP this season — tied for 2nd lowest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers have allowed a run 36% of the time after their offense scores this season — 2nd highest in MLB.

Opponents are hitting .254 against Orioles pitchers this season — 5th highest in MLB.

The Orioles have allowed 5.03 runs per game (317/63) on the road this season — tied for 5th highest in MLB.

Orioles pitchers are throwing just 3.82 pitches per plate appearance this season — tied for 5th lowest in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 32% of their games on the road this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 4th lowest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 4th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Orioles vs Cardinals and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.