• The Guardians are -140 favorites vs the Orioles
• Orioles vs Guardians Over / Under today: 7.5 Runs
• Orioles / Guardians TV Channel: GDTV | MASN

The Baltimore Orioles (+115) visit Progressive Field to take on the Cleveland Guardians (-140) on April 18, 2026. First pitch is scheduled for 6:10 pm in Cleveland, OH.

This season, the Orioles are 10-10 against the spread (ATS), while the Guardians are 11-10 ATS.

Orioles vs Guardians Starting Pitchers Today:

• Orioles starting pitcher: Dean Kremer 0-0, 3.60 ERA
• Guardians starting pitcher: Gavin Williams 2-1, 2.38 ERA

Orioles vs. Guardians Odds, Run Line, Over/Under & Moneyline

Orioles vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Saturday‘s MLB game with 51.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Orioles vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Orioles players for Saturday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

• Jeremiah Jackson has hit the Home Runs Over in 4 of his last 7 games (+30.50 Units / 436% ROI)
• Gunnar Henderson has hit the Hits Under in 14 of his last 20 games (+10.65 Units / 31% ROI)
• Pete Alonso has hit the Runs Under in 19 of his last 25 away games (+10.15 Units / 28% ROI)
• Pete Alonso has hit the Walks Over in 11 of his last 20 games (+9.05 Units / 45% ROI)
• Colton Cowser has hit the Hits Runs and RBIs Under in his last 8 away games (+8.80 Units / 84% ROI)

And here are some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Daniel Schneemann has hit the Home Runs Over in 2 of his last 4 games (+16.00 Units / 400% ROI)
• Gavin Williams has hit the Hits Allowed Under in 19 of his last 25 games (+11.55 Units / 38% ROI)
• Chase DeLauter has hit the Walks Over in 7 of his last 9 games (+9.25 Units / 103% ROI)
• Kyle Manzardo has hit the Hits Runs and RBIs Under in 12 of his last 15 games at home (+8.80 Units / 46% ROI)
• Daniel Schneemann has hit the Total Bases Over in 9 of his last 10 games (+7.90 Units / 61% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have hit the Team Total Under in 25 of their last 40 games (+8.35 Units / 17% ROI)
• The Baltimore Orioles have hit the Game Total Under in 27 of their last 45 games (+8.05 Units / 16% ROI)
• The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 40 games (+6.45 Units / 13% ROI)
• The Baltimore Orioles have hit the Moneyline in 16 of their last 30 away games (+5.00 Units / 15% ROI)
• The Baltimore Orioles have covered the Run Line in 6 of their last 10 games (+2.70 Units / 22% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 32 of their last 50 games (+17.55 Units / 30% ROI)
• The Cleveland Guardians have covered the Run Line in 30 of their last 50 games (+11.60 Units / 18% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 23 games (+10.10 Units / 36% ROI)
• The Cleveland Guardians have hit the Game Total Under in 27 of their last 45 games (+9.30 Units / 19% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 22 of their last 50 games (+8.55 Units / 15% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 8-12 against the Run Line (-4.55 Units / -18.61% ROI).

• 10-10 when betting on the Moneyline for -2.3 Units / -9.04% ROI
• 11-9 when betting on the total runs Over for +0.95 Units / 4.33% ROI
• 9-11 when betting on the total runs Under for -3.3 Units / -14.97% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 11-10 against the Run Line (+0.2 Units / 0.74% ROI).

• 11-10 when betting on the Moneyline for +3.4 Units / 14.88% ROI
• 10-11 when betting on the total runs Over for -2 Units / -8.68% ROI
• 11-10 when betting on the total runs Under for -0.15 Units / -0.65% ROI

Guardians vs Orioles Home Run Prop Bets Today

Guardians vs Orioles Total Hits Prop Bets Today

Guardians vs Orioles Strikeout Prop Bets Today

Orioles Keys to the Game vs. the Guardians

The Orioles are just 0-8 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .048.

The Orioles are just 12-73 (.141) when allowing 5 or more runs since the 2025 season — 5th lowest in MLB; League Avg: .206.

The Orioles are just 17-44 (.279) when their opponents score in the first inning since the 2025 season — 5th lowest in MLB; League Avg: .360.

The Orioles are just 1-85 (.012) when trailing entering the 9th inning since the 2025 season — 3rd lowest in MLB; League Avg: .044.

Guardians Keys to the Game vs. the Orioles

The Guardians are 36-4 (.878) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .749.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians were 24-2 (.923) when they had 5 or more XBH in the 2025 season — 2nd best in MLB; League Avg: .799.

The Guardians are 6-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .873.

Orioles Hitting Stats & Trends

Orioles hitters are slugging just .333 on the first pitch of at-bats this season — lowest in MLB.

Orioles hitters have an OPS of .790 (237 PA’s) in innings 7-9 this season — 5th best in MLB.

Orioles hitters have an OPS of just .428 (404 PA’s) with two-strikes this season — 4th lowest in MLB.

Orioles hitters are slugging just .185 with two-strikes this season — 2nd lowest in MLB.

Guardians Hitting Stats & Trends

The Guardians are batting just .191 in righty-righty matchups since the 2025 season — lowest in MLB.

The Guardians batted just .226 in the 2025 season — 2nd lowest in MLB.

Guardians hitters had an OBP of just .299 (4,160 PA’s) against RHP in the 2025 season — tied for 2nd lowest in MLB.

7% of Guardians’ hitters plate appearances have lasted only one pitch (54/777 PA’s) this season — lowest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers walked 10% of batters when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

Orioles pitchers have walked 10% of batters when facing the leadoff batter in the inning since the 2025 season — 2nd highest in MLB.

Orioles pitchers allowed an OBP of .352 (1,434 PA’s) when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

Orioles pitchers won only 16% of games in which they allowed their opponent to score in three different innings in the 2025 season — 3rd lowest in MLB.

Guardians Pitching Stats & Trends

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Guardians pitchers have a strikeout rate of 26% this season — 2nd best in MLB.

Guardians pitchers have a strikeout rate of 36% in close and late situations this season — best in MLB.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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