• The Cubs are -140 favorites vs the Pirates
• Pirates vs Cubs Over / Under today: 6.5 Runs
• Pirates / Cubs TV Channel: MARQ | SNPT

The Pittsburgh Pirates (+115) visit Wrigley Field to take on the Chicago Cubs (-140) on April 10, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Pirates are 7-5 against the spread (ATS), while the Cubs are 5-7 ATS.

Pirates vs Cubs Starting Pitchers Today:

• Pirates starting pitcher: Carmen Mlodzinski 0-0, 4.00 ERA
• Cubs starting pitcher: Shota Imanaga 0-1, 4.50 ERA

Pirates vs. Cubs Odds, Run Line, Over/Under & Moneyline

Pirates vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 60.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Friday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Oneil Cruz has hit the Walks Under in 13 of his last 15 games (+9.60 Units / 35% ROI)
• Marcell Ozuna has hit the Hits Runs and RBIs Under in his last 9 games (+9.00 Units / 77% ROI)
• Marcell Ozuna has hit the RBIs Under in his last 9 games (+9.00 Units / 42% ROI)
• Oneil Cruz has hit the Hits Over in 16 of his last 20 games (+9.00 Units / 25% ROI)
• Oneil Cruz has hit the Home Runs Over in 3 of his last 8 games (+8.10 Units / 101% ROI)

And here are some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Seiya Suzuki has hit the Home Runs Over in 5 of his last 9 games at home (+19.90 Units / 221% ROI)
• Seiya Suzuki has hit the Hits Over in 14 of his last 15 games (+12.45 Units / 44% ROI)
• Seiya Suzuki has hit the Total Bases Over in his last 10 games at home (+10.90 Units / 77% ROI)
• Moises Ballesteros has hit the Hits Runs and RBIs Over in 15 of his last 20 games (+10.75 Units / 47% ROI)
• Alex Bregman has hit the Runs Under in 13 of his last 15 games (+10.55 Units / 45% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 32 of their last 50 games (+10.70 Units / 16% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 27 of their last 45 away games (+9.80 Units / 20% ROI)
• The Pittsburgh Pirates have hit the Team Total Under in 30 of their last 50 away games (+7.95 Units / 13% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 away games (+7.85 Units / 13% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 13 of their last 20 games (+7.60 Units / 34% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 31 of their last 50 games at home (+12.10 Units / 15% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games at home (+10.40 Units / 18% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 30 games at home (+9.30 Units / 24% ROI)
• The Chicago Cubs have hit the Team Total Over in 19 of their last 30 games at home (+7.95 Units / 23% ROI)
• The Chicago Cubs have covered the Run Line in 10 of their last 14 games at home (+7.25 Units / 43% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 7-5 against the Run Line (+1.25 Units / 7.76% ROI).

• 7-5 when betting on the Moneyline for +2.2 Units / 15.94% ROI
• 7-5 when betting on the total runs Over for +1.55 Units / 11.92% ROI
• 5-7 when betting on the total runs Under for -2.85 Units / -21.27% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 5-7 against the Run Line (-1.6 Units / -12.03% ROI).

• 6-6 when betting on the Moneyline for -3.35 Units / -17.91% ROI
• 6-5 when betting on the total runs Over for +0.85 Units / 6.54% ROI
• 5-6 when betting on the total runs Under for -1.7 Units / -12.59% ROI

Pirates Keys to the Game vs. the Cubs

The Pirates are just 14-90 (.135) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB; League Avg: .251.

The Pirates are just 15-40 (.273) vs the top 10 runs allowed teams since the 2025 season Today, they face Cubs (10th in runs allowed).

The Pirates were just 1-80 (.012) when trailing entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .043.

The Pirates were just 5-65 (.071) when trailing entering the 7th inning in the 2025 season — 3rd lowest in MLB; League Avg: .124.

Cubs Keys to the Game vs. the Pirates

The Cubs are 51-6 (.895) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .748.

The Cubs are 42-9 (.824) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .640.

The Cubs were 48-6 (.889) when they had 10 or more hits in the 2025 season — best in MLB; League Avg: .743.

The Cubs are 74-19 (.796) when they’ve scored in the first inning since the 2024 season — best in MLB; League Avg: .640.

Pirates Hitting Stats & Trends

The Pirates won only 33% of their road games in the 2025 season — tied for 2nd lowest in MLB.

Pirates hitters slugged just .333 on the road in the 2025 season — 2nd lowest in MLB.

Pirates hitters had an OPS of just .662 (4,538 PA’s) against RHP in the 2025 season — lowest in MLB.

Pirates hitters slugged just .354 against RHP in the 2025 season — lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters had an OPS of .752 (1,589 PA’s) against LHP in the 2025 season — 5th best in MLB.

Cubs hitters have struck out in 28% of their PA’s against LHP this season — 5th highest in MLB.

Cubs hitters drew walks in 5% of their PA’s against pitchers who had thrown at least 80 pitches in a game in the 2025 season — lowest in MLB.

Cubs hitters have grounded into 78 double plays in 1,145 opportunities (7%) since the 2025 season — best in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 19% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Pirates pitchers have a strikeout rate of 35% in late innings this season — best in MLB.

Pirates pitchers have a strikeout rate of 49% with two-strikes this season — 4th best in MLB.

Pirates pitchers won only 14% of games in which they allowed their opponent to score in three different innings in the 2025 season — 2nd lowest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers walked 7% of batters in the 2025 season — best in MLB.

Cubs pitchers have a strikeout rate of just 7% in close and late situations this season — lowest in MLB.

Opponents have a miss rate of just 24% against Cubs pitchers since the 2025 season — 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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