• The Cubs are -135 favorites vs the Pirates
• Pirates vs Cubs Over / Under today: 12.5 Runs
• Pirates / Cubs TV Channel: MARQ | SNPT

The Pittsburgh Pirates (+110) visit Wrigley Field to take on the Chicago Cubs (-135) on April 12, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Pirates are 9-5 against the spread (ATS), while the Cubs are 5-9 ATS.

Pirates vs Cubs Starting Pitchers Today:

• Pirates starting pitcher: Bubba Chandler 0-1, 3.12 ERA
• Cubs starting pitcher: Jameson Taillon 0-1, 2.53 ERA

Pirates vs. Cubs Odds, Run Line, Over/Under & Moneyline

Pirates vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 52.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Pirates vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Pirates players for Sunday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Bets Today:

• Bryan Reynolds has hit the Home Runs Over in 3 of his last 4 away games (+15.80 Units / 395% ROI)
• Ryan O’Hearn has hit the Total Bases Over in 20 of his last 25 games (+15.10 Units / 44% ROI)
• Ryan O’Hearn has hit the Hits Over in 21 of his last 25 games (+14.45 Units / 34% ROI)
• Ryan O’Hearn has hit the Singles Over in 17 of his last 25 games (+11.80 Units / 46% ROI)
• Ryan O’Hearn has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+9.90 Units / 35% ROI)

And here are some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Michael Busch has hit the Hits Under in 12 of his last 15 games (+12.70 Units / 68% ROI)
• Ian Happ has hit the Singles Under in 20 of his last 25 games (+12.50 Units / 31% ROI)
• Michael Busch has hit the Total Bases Under in 13 of his last 15 games (+11.40 Units / 55% ROI)
• Ian Happ has hit the Home Runs Over in 4 of his last 9 games at home (+11.15 Units / 124% ROI)
• Alex Bregman has hit the Runs Under in 13 of his last 15 games (+10.55 Units / 46% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 32 of their last 50 games (+10.70 Units / 15% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 30 of their last 50 away games (+10.60 Units / 20% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 15 of their last 22 games (+10.20 Units / 42% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 games (+9.60 Units / 20% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 31 of their last 50 away games (+9.35 Units / 15% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+9.70 Units / 12% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games at home (+8.35 Units / 14% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 40 games (+5.90 Units / 11% ROI)
• The Chicago Cubs have hit the Team Total Over in 14 of their last 22 games at home (+5.65 Units / 22% ROI)
• The Chicago Cubs have covered the Run Line in 10 of their last 16 games at home (+5.25 Units / 28% ROI)

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 9-5 against the Run Line (+3.25 Units / 16.46% ROI).

• 9-5 when betting on the Moneyline for +4.8 Units / 30.38% ROI
• 8-6 when betting on the total runs Over for +1.35 Units / 8.82% ROI
• 6-8 when betting on the total runs Under for -2.95 Units / -19.03% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 5-9 against the Run Line (-3.6 Units / -23.53% ROI).

• 6-8 when betting on the Moneyline for -6.35 Units / -29.26% ROI
• 7-6 when betting on the total runs Over for +0.65 Units / 4.25% ROI
• 6-7 when betting on the total runs Under for -1.8 Units / -11.54% ROI

Pirates Keys to the Game vs. the Cubs

The Pirates are just 14-90 (.135) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB; League Avg: .251.

The Pirates are just 6-53 (.102) when allowing 5 or more runs since the 2025 season — 2nd lowest in MLB; League Avg: .203.

The Pirates were just 6-35 (.146) when allowing 2 or more home runs in the 2025 season — lowest in MLB; League Avg: .301.

The Pirates are just 32-57 (.360) on the road since the 2025 season — 3rd lowest in MLB; League Avg: .456.

Cubs Keys to the Game vs. the Pirates

The Cubs are 51-26 (.662) after a loss since the 2025 season — best in MLB; League Avg: .482.

The Cubs are just 0-8 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .026.

The Cubs are 51-6 (.895) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .748.

The Cubs were 40-9 (.816) when they scored in the first inning in the 2025 season — best in MLB; League Avg: .636.

Pirates Hitting Stats & Trends

The Pirates batted just .121 in lefty-lefty matchups in the 2025 season — lowest in MLB.

Pirates hitters had an OPS of just .622 (3,034 PA’s) on the road in the 2025 season — 2nd lowest in MLB.

Pirates hitters had an OPS of just .655 (6,009 PA’s) in the 2025 season — lowest in MLB.

Pirates hitters slugged just .333 on the road in the 2025 season — 2nd lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters had an OPS of .752 (1,589 PA’s) against LHP in the 2025 season — 5th best in MLB.

Cubs hitters slugged .434 against LHP in the 2025 season — 4th best in MLB.

Cubs hitters have struck out in 29% of their PA’s against LHP this season — 5th highest in MLB.

Cubs hitters drew walks in 5% of their PA’s against pitchers who had thrown at least 80 pitches in a game in the 2025 season — lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 18% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Pirates pitchers have walked 12% of batters this season — 5th highest in MLB.

Pirates pitchers have a strikeout rate of 28% with runners in scoring position this season — 4th best in MLB.

Pirates pitchers have a strikeout rate of 48% with two-strikes this season — 3rd best in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers picked-off 25 runners from first base in the 2025 season — most in MLB.

Cubs pitchers walked 7% of batters in the 2025 season — best in MLB.

Cubs pitchers picked-off 27 runners in the 2025 season — most in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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