• The Cardinals are -145 favorites vs the Reds
• Reds vs Cardinals Over / Under today: 9 Runs
• Reds / Cardinals TV Channel: CATV | RDTV

The Cincinnati Reds (+120) visit Busch Stadium to take on the St. Louis Cardinals (-145) on June 5, 2026. First pitch is scheduled for 8:15 pm in St. Louis, MO.

This season, the Reds are 31-30 against the spread (ATS), while the Cardinals are 36-23 ATS.

Reds vs Cardinals Starting Pitchers Today:

• Reds starting pitcher: Brady Singer 2-5, 6.18 ERA
• Cardinals starting pitcher: Kyle Leahy 5-3, 4.26 ERA

Reds vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Reds vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Friday‘s MLB game with 56.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Friday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Spencer Steer has hit the Total Bases Over in 18 of his last 20 away games (+17.20 Units / 61% ROI)
• Spencer Steer has hit the Hits Over in 19 of his last 20 away games (+16.90 Units / 48% ROI)
• Will Benson has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+14.45 Units / 43% ROI)
• Matt McLain has hit the Home Runs Over in 2 of his last 10 away games (+12.00 Units / 120% ROI)
• Will Benson has hit the Runs Under in 20 of his last 25 games (+10.55 Units / 21% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Ivan Herrera has hit the Home Runs Over in 3 of his last 9 games at home (+16.40 Units / 182% ROI)
• Alec Burleson has hit the Runs Under in 20 of his last 25 games at home (+11.45 Units / 26% ROI)
• Alec Burleson has hit the Singles Over in 16 of his last 20 games (+11.35 Units / 45% ROI)
• Jordan Walker has hit the Total Bases Under in 16 of his last 20 games at home (+10.25 Units / 33% ROI)
• Alec Burleson has hit the RBIs Over in 11 of his last 20 games at home (+9.30 Units / 47% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Over in 33 of their last 50 games (+14.00 Units / 25% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 14 of their last 22 games (+5.55 Units / 22% ROI)
• The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 10 of their last 14 away games (+5.35 Units / 31% ROI)
• The Cincinnati Reds have hit the Team Total Under in 6 of their last 7 games (+5.10 Units / 61% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 6 of their last 9 away games (+4.50 Units / 47% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 24 of their last 40 games (+8.70 Units / 20% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 28 of their last 45 games (+8.20 Units / 15% ROI)
• The St. Louis Cardinals have hit the Moneyline in 27 of their last 50 games (+7.50 Units / 14% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 21 of their last 45 games (+6.90 Units / 14% ROI)
• The St. Louis Cardinals have covered the Run Line in 29 of their last 45 games (+6.15 Units / 9% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 34-26 against the Run Line (+1.5 Units / 1.7% ROI).

• 31-30 when betting on the Moneyline for -0.25 Units / -0.36% ROI
• 37-23 when betting on the total runs Over for +11.45 Units / 16.95% ROI
• 23-37 when betting on the total runs Under for -17.5 Units / -26.26% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 36-23 against the Run Line (+3.5 Units / 3.94% ROI).

• 32-28 when betting on the Moneyline for +8.45 Units / 13.64% ROI
• 26-31 when betting on the total runs Over for -8 Units / -12.16% ROI
• 31-26 when betting on the total runs Under for +2.2 Units / 3.32% ROI

Cardinals vs Reds Home Run Prop Bets Today

Cardinals vs Reds Total Hits Prop Bets Today

Cardinals vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Cardinals

The Reds are 4-26 (.133) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .055.

The Reds are 25-1 (.962) when leading entering the 8th inning this season — 5th best in MLB; League Avg: .893.

The Reds are 26-5 (.839) when allowing 4 or fewer runs this season — 4th best in MLB; League Avg: .722.

The Reds are just 12-53 (.185) when allowing 10 or more hits since the 2025 season — 5th lowest in MLB; League Avg: .253.

Cardinals Keys to the Game vs. the Reds

The Cardinals are 3-24 (.111) when trailing entering the 9th inning this season — tied for 4th best in MLB; League Avg: .055.

The Cardinals are 13-3 (.812) when they’ve scored in the first inning this season — 3rd best in MLB; League Avg: .648.

The Cardinals are 10-4 (.714) vs the bottom 10 runs allowed teams this season Today, they face the Reds (25th runs allowed).

The Cardinals are just 9-91 (.090) when trailing entering the 7th inning since the 2025 season — 4th lowest in MLB; League Avg: .129.

Reds Hitting Stats & Trends

The Reds are batting just .201 with two outs this season — lowest in MLB.

The Reds are batting just .116 on pitches out of the zone this season — lowest in MLB.

Reds hitters have struck out in 24% of their PA’s against RHP this season — 2nd highest in MLB.

Reds hitters have struck out in 26% of their PA’s against LHP this season — 4th highest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have 82 extra-base hits out of 287 total hits (just 29%) against starting pitchers this season — lowest in MLB.

The Cardinals are batting just .216 with two outs this season — 5th lowest in MLB.

Cardinals hitters have struck out in just 16% of their PA’s in lefty-lefty matchups this season — best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a first-pitch strike rate of just 57% this season — 2nd lowest in MLB.

Reds pitchers have walked 12% of batters this season — 3rd highest in MLB.

Reds pitchers have an ERA of 6.60 (106.1 IP) against division opponents this season — highest in MLB.

Opponents have a groundball rate of just 40% against Reds pitchers this season — 3rd lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 17% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — tied for 3rd lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 4th highest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 3rd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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