• The Cardinals are -130 favorites vs the Reds
• Reds vs Cardinals Over / Under today: 9 Runs
• Reds / Cardinals TV Channel: CATV | RDTV

The Cincinnati Reds (+105) visit Busch Stadium to take on the St. Louis Cardinals (-130) on June 6, 2026. First pitch is scheduled for 2:15 pm in St. Louis, MO.

This season, the Reds are 31-31 against the spread (ATS), while the Cardinals are 37-23 ATS.

Reds vs Cardinals Starting Pitchers Today:

• Reds starting pitcher: Nick Lodolo 2-1, 5.21 ERA
• Cardinals starting pitcher: Matthew Liberatore 3-3, 4.36 ERA

Reds vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Reds vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Saturday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Saturday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Spencer Steer has hit the Total Bases Over in 17 of his last 20 away games (+15.20 Units / 55% ROI)
• Spencer Steer has hit the Hits Over in 18 of his last 20 away games (+13.60 Units / 38% ROI)
• Matt McLain has hit the Home Runs Over in 2 of his last 10 away games (+12.00 Units / 120% ROI)
• Spencer Steer has hit the Runs Over in 16 of his last 25 games (+11.55 Units / 46% ROI)
• Eugenio Suarez has hit the Singles Over in 12 of his last 20 away games (+9.75 Units / 49% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Alec Burleson has hit the RBIs Over in 15 of his last 25 games at home (+14.50 Units / 58% ROI)
• Alec Burleson has hit the Singles Over in 19 of his last 25 games (+12.00 Units / 38% ROI)
• Nolan Gorman has hit the Runs Under in 17 of his last 20 games (+11.20 Units / 29% ROI)
• Pedro Pages has hit the Home Runs Over in 2 of his last 10 games at home (+10.00 Units / 100% ROI)
• Alec Burleson has hit the Hits Over in 18 of his last 25 games (+8.70 Units / 18% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Over in 33 of their last 50 games (+14.00 Units / 25% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 40 away games (+7.10 Units / 14% ROI)
• The Cincinnati Reds have hit the Team Total Under in 7 of their last 8 games (+6.10 Units / 63% ROI)
• The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 10 of their last 15 away games (+4.10 Units / 22% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 6 of their last 10 away games (+3.50 Units / 33% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games (+10.65 Units / 19% ROI)
• The St. Louis Cardinals have covered the Run Line in 30 of their last 45 games (+9.25 Units / 14% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 22 of their last 45 games (+8.95 Units / 19% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 24 of their last 40 games (+8.75 Units / 20% ROI)
• The St. Louis Cardinals have hit the Moneyline in 25 of their last 45 games (+8.40 Units / 18% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 34-27 against the Run Line (-0.15 Units / -0.17% ROI).

• 31-31 when betting on the Moneyline for -1.25 Units / -1.77% ROI
• 38-23 when betting on the total runs Over for +12.45 Units / 18.11% ROI
• 23-38 when betting on the total runs Under for -18.5 Units / -27.35% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 37-23 against the Run Line (+4.95 Units / 5.51% ROI).

• 33-28 when betting on the Moneyline for +9.45 Units / 14.92% ROI
• 27-31 when betting on the total runs Over for -7 Units / -10.45% ROI
• 31-27 when betting on the total runs Under for +1.2 Units / 1.78% ROI

Cardinals vs Reds Home Run Prop Bets Today

Cardinals vs Reds Total Hits Prop Bets Today

Cardinals vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Cardinals

The Reds are 4-26 (.133) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .055.

The Reds are 26-5 (.839) when allowing 4 or fewer runs this season — 4th best in MLB; League Avg: .722.

The Reds are 25-1 (.962) when leading entering the 8th inning this season — 5th best in MLB; League Avg: .893.

The Reds are just 12-75 (.138) when allowing 5 or more runs since the 2025 season — 3rd lowest in MLB; League Avg: .204.

Cardinals Keys to the Game vs. the Reds

The Cardinals are 10-4 (.714) vs the bottom 10 runs allowed teams this season Today, they face the Reds (25th runs allowed).

The Cardinals are 3-24 (.111) when trailing entering the 9th inning this season — tied for 4th best in MLB; League Avg: .055.

The Cardinals are 13-3 (.812) when they’ve scored in the first inning this season — 3rd best in MLB; League Avg: .648.

The Cardinals are just 9-91 (.090) when trailing entering the 7th inning since the 2025 season — 4th lowest in MLB; League Avg: .129.

Reds Hitting Stats & Trends

The Reds are batting just .201 with two outs this season — lowest in MLB.

The Reds are batting just .216 with runners on base this season — lowest in MLB.

Reds hitters have struck out in 25% of their PA’s this season — tied for highest in MLB.

Reds hitters have struck out in 24% of their PA’s against RHP this season — 2nd highest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have an OBP of just .305 (613 PA’s) with runners in scoring position this season — lowest in MLB.

Games involving the Cardinals went OVER in 79% of their games (50.1% ROI) vs the bottom 10 runs allowed teams this season Today, they face the Reds (25th runs allowed).

The Cardinals have scored 84 runs with two outs this season — 2nd fewest in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a strike rate of just 61% this season — lowest in MLB.

Reds pitchers have walked 12% of batters this season — 3rd highest in MLB.

Reds pitchers have a first-pitch strike rate of just 57% this season — 2nd lowest in MLB.

Reds pitchers have a strikeout rate of just 20% this season — 3rd lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 4th highest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 90.1 MPH this season (1,596 balls in play) — highest in MLB

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 3rd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 17% with runners in scoring position this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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