• The Guardians are -140 favorites vs the Reds
• Reds vs Guardians Over / Under today: 8 Runs
• Reds / Guardians TV Channel: GDTV | WKYC | RDTV

The Cincinnati Reds (+115) visit Progressive Field to take on the Cleveland Guardians (-140) on May 15, 2026. First pitch is scheduled for 7:10 pm in Cleveland, OH.

This season, the Reds are 23-21 against the spread (ATS), while the Guardians are 23-22 ATS.

Reds vs Guardians Starting Pitchers Today:

• Reds starting pitcher: Andrew Abbott 2-2, 4.54 ERA
• Guardians starting pitcher: Tanner Bibee 0-5, 4.17 ERA

Reds vs. Guardians Odds, Run Line, Over/Under & Moneyline

Reds vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Friday‘s MLB game with 53.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Reds vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Reds players for Friday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

• Tyler Stephenson has hit the Runs Under in 18 of his last 20 games (+14.80 Units / 38% ROI)
• JJ Bleday has hit the Home Runs Over in 3 of his last 6 away games (+14.70 Units / 245% ROI)
• TJ Friedl has hit the Walks Under in 21 of his last 25 games (+14.65 Units / 32% ROI)
• Sal Stewart has hit the RBIs Under in 18 of his last 20 games (+14.50 Units / 42% ROI)
• Spencer Steer has hit the Total Bases Over in 17 of his last 20 away games (+12.90 Units / 44% ROI)

And here are some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Angel Martinez has hit the Home Runs Over in 3 of his last 9 games at home (+17.10 Units / 190% ROI)
• Jose Ramirez has hit the RBIs Under in 21 of his last 25 games (+13.50 Units / 28% ROI)
• Daniel Schneemann has hit the Total Bases Over in 19 of his last 25 games (+11.80 Units / 35% ROI)
• Daniel Schneemann has hit the Hits Over in 19 of his last 25 games (+10.00 Units / 27% ROI)
• Rhys Hoskins has hit the Runs Over in 14 of his last 25 games (+9.75 Units / 39% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Over in 24 of their last 35 games (+11.60 Units / 30% ROI)
• The Cincinnati Reds have covered the Run Line in 18 of their last 30 games (+5.50 Units / 13% ROI)
• The Cincinnati Reds have hit the Team Total Under in 29 of their last 50 away games (+4.75 Units / 8% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 4 of their last 5 games (+3.10 Units / 56% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 14 of their last 30 games (+1.90 Units / 5% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the Run Line in 25 of their last 45 games at home (+10.05 Units / 19% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 25 of their last 40 games (+9.70 Units / 21% ROI)
• The Cleveland Guardians have hit the Game Total Under in 25 of their last 40 games at home (+9.35 Units / 21% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 14 games (+7.65 Units / 45% ROI)
• The Cleveland Guardians have hit the Moneyline in 28 of their last 45 games at home (+7.55 Units / 13% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 26-17 against the Run Line (+5 Units / 7.87% ROI).

• 23-21 when betting on the Moneyline for +0.85 Units / 1.67% ROI
• 27-16 when betting on the total runs Over for +9.2 Units / 18.91% ROI
• 16-27 when betting on the total runs Under for -13.65 Units / -28.35% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 23-22 against the Run Line (+1.6 Units / 2.85% ROI).

• 24-21 when betting on the Moneyline for +2.9 Units / 5.43% ROI
• 22-23 when betting on the total runs Over for -3.1 Units / -6.28% ROI
• 23-22 when betting on the total runs Under for -1.35 Units / -2.71% ROI

Guardians vs Reds Home Run Prop Bets Today

Guardians vs Reds Total Hits Prop Bets Today

Guardians vs Reds Strikeout Prop Bets Today

Reds Keys to the Game vs. the Guardians

The Reds are 3-18 (.143) when trailing entering the 9th inning this season — tied for 3rd best in MLB; League Avg: .051.

The Reds are 5-1 (.833) vs bottom 10 scoring offenses this season Today, they face the Guardians (24th in runs scored).

The Reds are just 1-5 (.167) vs the top 10 runs allowed teams this season Today, they face Guardians (eighth in runs allowed).

The Reds are 20-4 (.833) when allowing 4 or fewer runs this season — tied for 4th best in MLB; League Avg: .721.

Guardians Keys to the Game vs. the Reds

The Guardians are just 0-19 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

The Guardians are just 9-14 (.391) after a win this season — tied for 5th lowest in MLB; League Avg: .524.

The Guardians are 18-1 (.947) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .865.

The Guardians are 62-47 (.564) after a win since the 2025 season — 5th best in MLB; League Avg: .519.

Reds Hitting Stats & Trends

The Reds are batting just .193 with two outs this season — tied for 2nd lowest in MLB.

The Reds are batting just .130 in lefty-lefty matchups this season — lowest in MLB.

Reds hitters have an OBP of just .292 (753 PA’s) with runners on base this season — lowest in MLB.

The Reds are batting just .202 with runners on base this season — lowest in MLB.

Guardians Hitting Stats & Trends

8% of Guardians’ hitters plate appearances have lasted only one pitch (139/1,689 PA’s) this season — lowest in MLB.

Guardians hitters are slugging just .348 against RHP this season — 2nd lowest in MLB.

Guardians hitters have a groundball batting average of just .197 this season — lowest in MLB.

Guardians hitters have struck out in just 20% of their PA’s this season — 3rd best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a first-pitch strike rate of just 56% this season — lowest in MLB.

Reds pitchers have walked 12% of batters this season — 3rd highest in MLB.

Opponents have a groundball rate of just 41% against Reds pitchers this season — 5th lowest in MLB.

Reds pitchers have thrown at least two strikes in their first three pitches to 58% of opposing batters this season — 2nd lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 35% in close and late situations this season — best in MLB.

Guardians pitchers have struck out 28% of left-handed batters they faced this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 2nd best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — tied for best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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