• The Twins are -155 favorites vs the Giants
• Twins vs Giants Over / Under today: 7.5 Runs
• Twins / Giants TV Channel: TWTV | NSBA

The Minnesota Twins (-155) visit Oracle Park to take on the San Francisco Giants (+125) on September 23, 2026. First pitch is scheduled for 3:45 pm in San Francisco, CA.

This season, the Twins are 74-84 against the spread (ATS), while the Giants are 78-78 ATS.

Twins vs Giants Starting Pitchers Today:

• Twins starting pitcher: Connor Prielipp 6-7, 4.97 ERA
• Giants starting pitcher: Cesar Perdomo 0-1, 3.73 ERA

Twins vs. Giants Odds, Run Line, Over/Under & Moneyline

Twins vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Wednesday‘s MLB game with 59.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Twins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Walker Jenkins has hit the Home Runs Over in 3 of his last 6 games (+21.50 Units / 358% ROI)
• Royce Lewis has hit the Runs Under in 19 of his last 20 away games (+17.30 Units / 50% ROI)
• Austin Martin has hit the Hits Under in 14 of his last 20 away games (+13.55 Units / 68% ROI)
• Austin Martin has hit the Total Bases Under in 16 of his last 20 away games (+13.05 Units / 48% ROI)
• Austin Martin has hit the Singles Under in 16 of his last 20 away games (+11.95 Units / 51% ROI)

And here are some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Jonah Cox has hit the Runs Over in 14 of his last 25 games (+10.80 Units / 43% ROI)
• Christian Koss has hit the Hits Runs and RBIs Over in 14 of his last 20 games at home (+9.85 Units / 40% ROI)
• Drew Cavanaugh has hit the Home Runs Over in 1 of his last 4 games at home (+9.00 Units / 225% ROI)
• Turner Hill has hit the Hits Under in 7 of his last 8 games at home (+8.70 Units / 109% ROI)
• Jonah Cox has hit the Singles Over in 14 of his last 20 games (+8.60 Units / 40% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Game Total Over in 28 of their last 50 away games (+9.10 Units / 16% ROI)
• The Minnesota Twins have hit the Team Total Under in 15 of their last 24 away games (+5.65 Units / 21% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 19 games (+4.00 Units / 17% ROI)
• The Minnesota Twins have covered the Run Line in 3 of their last 5 games (+2.00 Units / 33% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 3 of their last 5 games (+1.25 Units / 23% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 29 of their last 40 games (+16.45 Units / 33% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 22 of their last 30 games at home (+12.40 Units / 34% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 19 of their last 30 games at home (+11.80 Units / 33% ROI)
• The San Francisco Giants have hit the Team Total Over in 13 of their last 17 games at home (+8.85 Units / 44% ROI)
• The San Francisco Giants have hit the Game Total Over in 14 of their last 22 games (+6.25 Units / 26% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 82-74 against the Run Line (-10.3 Units / -4.62% ROI).

• 74-84 when betting on the Moneyline for -9.8 Units / -5.54% ROI
• 85-63 when betting on the total runs Over for +15 Units / 8.59% ROI
• 63-85 when betting on the total runs Under for -30.7 Units / -17.71% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 78-78 against the Run Line (-19.1 Units / -8.78% ROI).

• 65-93 when betting on the Moneyline for -22.3 Units / -12.88% ROI
• 75-70 when betting on the total runs Over for -2.05 Units / -1.18% ROI
• 70-75 when betting on the total runs Under for -12.25 Units / -7.06% ROI

Twins Keys to the Game vs. the Giants

The Twins are just 26-23 (.531) when they’ve hit 2 or more home runs this season — 2nd lowest in MLB.

The Twins are just 14-9 (.609) when they’ve had 5 or more XBH this season — 2nd lowest in MLB.

The Twins are just 20-27 (.426) vs the bottom 10 runs allowed teams this season Today, they face the Giants (23rd fewest runs allowed).

The Twins are just 2-72 (.027) when trailing entering the 9th inning this season — tied for 3rd lowest in MLB.

Giants Keys to the Game vs. the Twins

The Giants are just 2-68 (.029) when trailing entering the 7th inning this season — 2nd lowest in MLB.

The Giants are just 19-31 (.380) vs bottom 10 scoring offenses this season Today, they face the Twins (10th in runs scored).

The Giants are just 2-73 (.027) when trailing entering the 8th inning this season — lowest in MLB.

The Giants are just 2-76 (.026) when trailing entering the 9th inning this season — 2nd lowest in MLB.

Twins Hitting Stats & Trends

The Twins are batting just .198 on changeups this season — 2nd lowest in MLB.

Twins hitters are slugging .421 on breaking pitches against RHP this season — tied for best in MLB.

Twins hitters have 96 extra-base hits out of 212 total hits (45%) on the first pitch of at-bats this season — best in MLB.

Twins hitters have an OPS of just .676 (1,846 PA’s) against LHP this season — 5th lowest in MLB.

Giants Hitting Stats & Trends

Giants hitters have drawn walks in 7% of their PA’s this season — lowest in MLB.

The Giants are batting .253 with two outs this season — 2nd best in MLB.

Giants hitters have an OBP of just .309 (5,927 PA’s) this season — 2nd lowest in MLB.

The Giants have a winning percentage of just 35% on the road this season — tied for 3rd lowest in MLB.

Twins Pitching Stats & Trends

Twins pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Opponents have a groundball rate of just 40% against Twins pitchers this season — tied for 4th lowest in MLB.

The Twins have allowed 5.29 runs per game (423/80) on the road this season — 3rd highest in MLB.

Twins pitchers have allowed innings of 3+ runs in 7% of innings played this season — tied for 4th highest in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

Opponents have a miss rate of just 23% against Giants pitchers this season — tied for 3rd lowest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 59% of opposing batters this season — lowest in MLB.

The Giants have won just 5% of road games in which their opponents scored first this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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