• The Guardians are -160 favorites vs the Twins
• Twins vs Guardians Over / Under today: 7.5 Runs
• Twins / Guardians TV Channel: GDTV | TWTV

The Minnesota Twins (+135) visit Progressive Field to take on the Cleveland Guardians (-160) on May 10, 2026. First pitch is scheduled for 1:40 pm in Cleveland, OH.

This season, the Twins are 17-23 against the spread (ATS), while the Guardians are 21-20 ATS.

Twins vs Guardians Starting Pitchers Today:

• Twins starting pitcher: Andrew Morris 1-1, 5.07 ERA
• Guardians starting pitcher: Gavin Williams 5-2, 3.24 ERA

Twins vs. Guardians Odds, Run Line, Over/Under & Moneyline

Twins vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Sunday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Byron Buxton has hit the Home Runs Over in 6 of his last 9 games (+18.00 Units / 200% ROI)
• Josh Bell has hit the Total Bases Under in 16 of his last 20 games (+12.75 Units / 42% ROI)
• Ryan Jeffers has hit the Walks Over in 8 of his last 10 away games (+9.60 Units / 96% ROI)
• Ryan Jeffers has hit the Hits Over in 16 of his last 20 games (+9.60 Units / 27% ROI)
• Josh Bell has hit the Runs Under in 16 of his last 20 games (+9.00 Units / 25% ROI)

And here are some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Daniel Schneemann has hit the Total Bases Over in 19 of his last 25 games (+12.00 Units / 36% ROI)
• Jose Ramirez has hit the RBIs Under in 17 of his last 20 games (+11.45 Units / 30% ROI)
• Daniel Schneemann has hit the Hits Over in 19 of his last 25 games (+10.20 Units / 28% ROI)
• Kyle Manzardo has hit the Runs Under in his last 10 games at home (+10.00 Units / 52% ROI)
• Daniel Schneemann has hit the Home Runs Over in 2 of his last 9 games at home (+9.90 Units / 110% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 26 of their last 40 away games (+10.15 Units / 22% ROI)
• The Minnesota Twins have hit the Game Total Over in 19 of their last 30 games (+9.00 Units / 27% ROI)
• The Minnesota Twins have hit the Team Total Over in 25 of their last 40 games (+7.40 Units / 15% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 22 of their last 45 games (+5.70 Units / 11% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 26 of their last 45 games (+4.55 Units / 8% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the Run Line in 23 of their last 40 games at home (+10.25 Units / 21% ROI)
• The Cleveland Guardians have hit the Game Total Under in 22 of their last 35 games at home (+8.65 Units / 22% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 19 of their last 30 games at home (+7.45 Units / 21% ROI)
• The Cleveland Guardians have hit the Moneyline in 25 of their last 40 games at home (+7.30 Units / 14% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 21 of their last 35 games (+6.75 Units / 17% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 19-21 against the Run Line (-10.45 Units / -17.97% ROI).

• 17-23 when betting on the Moneyline for -4.75 Units / -11.23% ROI
• 23-14 when betting on the total runs Over for +7.5 Units / 17.03% ROI
• 14-23 when betting on the total runs Under for -11.35 Units / -25.82% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 21-20 against the Run Line (+0.8 Units / 1.54% ROI).

• 21-20 when betting on the Moneyline for +1.5 Units / 3.17% ROI
• 20-21 when betting on the total runs Over for -2.95 Units / -6.53% ROI
• 21-20 when betting on the total runs Under for -1.05 Units / -2.32% ROI

Guardians vs Twins Home Run Prop Bets Today

Guardians vs Twins Total Hits Prop Bets Today

Guardians vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the Guardians

The Twins are just 1-9 (.100) when allowing 2 or more home runs this season — 3rd lowest in MLB; League Avg: .298.

The Twins are just 0-17 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .105.

The Twins are just 2-17 (.105) when allowing 5 or more runs this season — 3rd lowest in MLB; League Avg: .213.

The Twins are just 8-12 (.400) vs bottom 10 scoring offenses this season Today, they face the Guardians (21st in runs scored).

Guardians Keys to the Game vs. the Twins

The Guardians are 8-0 (1.000) when they’ve had 10 or more hits this season — tied for best in MLB; League Avg: .755.

The Guardians are 15-1 (.938) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .862.

The Guardians are 13-6 (.684) after a loss this season — 3rd best in MLB; League Avg: .475.

The Guardians are just 0-18 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

Twins Hitting Stats & Trends

The Twins are batting just .194 with two outs this season — 3rd lowest in MLB.

Twins hitters have put just 30% of their swings in play on the first pitch of at-bats this season — 2nd lowest in MLB.

Twins hitters have an OBP of .337 (533 PA’s) against LHP this season — tied for 4th best in MLB.

Twins hitters have a Hard-Hit Rate of just 34% on pitches 95 mph or greater this season — lowest in MLB.

Guardians Hitting Stats & Trends

8% of Guardians’ hitters plate appearances have lasted only one pitch (126/1,541 PA’s) this season — lowest in MLB.

Guardians hitters are averaging 4.09 pitches per plate appearance this season — highest in MLB.

Guardians hitters have a groundball batting average of just .188 this season — lowest in MLB.

Guardians hitters have put just 29% of their swings in play on the first pitch of at-bats this season — lowest in MLB.

Twins Pitching Stats & Trends

The Twins have allowed 1.92 runs per game (77/40) in late innings this season — highest in MLB.

Twins pitchers have a strikeout rate of just 39% with two-strikes this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 20% this season — tied for 4th lowest in MLB.

Opponents have a miss rate of just 22% against Twins pitchers this season — 3rd lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have struck out 28% of left-handed batters they faced this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 4th best in MLB.

Opponents have a miss rate of 27% against Guardians pitchers this season — 5th best in MLB.

Guardians pitchers have a strikeout rate of 34% in close and late situations this season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Twins vs Guardians and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.