• The White Sox are -130 favorites vs the Twins
• Twins vs White Sox Over / Under today: 8 Runs
• Twins / White Sox TV Channel: TWTV | CHSN

The Minnesota Twins (+105) visit Rate Field to take on the Chicago White Sox (-130) on May 27, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Twins are 27-28 against the spread (ATS), while the White Sox are 30-23 ATS.

Twins vs White Sox Starting Pitchers Today:

• Twins starting pitcher: Connor Prielipp 1-2, 3.95 ERA
• White Sox starting pitcher: Davis Martin 7-1, 2.06 ERA

Twins vs. White Sox Odds, Run Line, Over/Under & Moneyline

Twins vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Wednesday‘s MLB game with 55.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Victor Caratini has hit the Hits Under in 17 of his last 25 games (+15.25 Units / 61% ROI)
• Victor Caratini has hit the Runs Under in his last 15 away games (+15.00 Units / 47% ROI)
• Victor Caratini has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+13.80 Units / 40% ROI)
• Victor Caratini has hit the Total Bases Under in 17 of his last 25 games (+12.15 Units / 43% ROI)
• Trevor Larnach has hit the Walks Under in 13 of his last 15 games (+10.50 Units / 40% ROI)

And here are some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Drew Romo has hit the Home Runs Over in 3 of his last 9 games at home (+21.50 Units / 239% ROI)
• Chase Meidroth has hit the Runs Over in 15 of his last 25 games (+13.20 Units / 53% ROI)
• Luisangel Acuna has hit the Hits Under in 14 of his last 20 games (+11.75 Units / 59% ROI)
• Chase Meidroth has hit the Total Bases Over in 18 of his last 25 games (+10.70 Units / 29% ROI)
• Chase Meidroth has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.55 Units / 40% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Team Total Over in 32 of their last 50 games (+11.85 Units / 20% ROI)
• The Minnesota Twins have covered the Run Line in 13 of their last 16 games (+10.50 Units / 46% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 45 games (+9.35 Units / 17% ROI)
• The Minnesota Twins have hit the Game Total Over in 26 of their last 45 games (+8.30 Units / 17% ROI)
• The Minnesota Twins have hit the Moneyline in 11 of their last 16 games (+6.80 Units / 39% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 23 of their last 35 games (+9.70 Units / 24% ROI)
• The Chicago White Sox have hit the Moneyline in 21 of their last 35 games (+9.10 Units / 25% ROI)
• The Chicago White Sox have hit the Game Total Over in 11 of their last 14 games (+8.95 Units / 59% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 17 games (+8.85 Units / 42% ROI)
• The Chicago White Sox have covered the Run Line in 23 of their last 35 games (+8.60 Units / 16% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 31-24 against the Run Line (-0.95 Units / -1.2% ROI).

• 27-28 when betting on the Moneyline for +1.05 Units / 1.79% ROI
• 30-21 when betting on the total runs Over for +6.8 Units / 11.21% ROI
• 21-30 when betting on the total runs Under for -12.1 Units / -20.03% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 30-23 against the Run Line (-2.35 Units / -2.95% ROI).

• 27-27 when betting on the Moneyline for +4.6 Units / 8.21% ROI
• 32-21 when betting on the total runs Over for +9.2 Units / 15.62% ROI
• 21-32 when betting on the total runs Under for -14.45 Units / -24.12% ROI

White Sox vs Twins Home Run Prop Bets Today

White Sox vs Twins Total Hits Prop Bets Today

White Sox vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the White Sox

The Twins are just 0-21 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .102.

The Twins are just 0-24 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Twins are just 2-5 (.286) when tied entering the 7th inning this season — tied for 4th lowest in MLB; League Avg: .500.

The Twins are just 7-24 (.226) when tied entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .500.

White Sox Keys to the Game vs. the Twins

The White Sox are just 25-110 (.185) when scoring 4 or fewer runs since the 2025 season — 2nd lowest in MLB; League Avg: .285.

The White Sox are just 65-18 (.783) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .872.

The White Sox are just 84-109 (.435) when allowing 5 or more extra base hits since the 2025 season — 2nd lowest in MLB; League Avg: .534.

The White Sox are just 20-45 (.308) vs top 10 scoring offenses since the 2025 season Today, they face the Twins (10th in runs scored).

Twins Hitting Stats & Trends

The Twins are batting just .203 with two outs this season — 3rd lowest in MLB.

Twins hitters have an OBP of .339 (684 PA’s) against LHP this season — tied for 5th best in MLB.

Twins hitters have put just 31% of their swings in play on the first pitch of at-bats this season — tied for 2nd lowest in MLB.

Twins hitters have a 53% QAB rate with runners in scoring position this season — best in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have struck out in 24% of their PA’s against RHP this season — 2nd highest in MLB.

White Sox hitters are slugging .695 on the first pitch of at-bats this season — 2nd best in MLB.

White Sox hitters have an OPS of .781 (552 PA’s) against LHP this season — 4th best in MLB.

White Sox hitters have missed on 29% of swings this season — highest in MLB.

Twins Pitching Stats & Trends

Opponents have a groundball rate of just 40% against Twins pitchers this season — 3rd lowest in MLB.

Opponents have a miss rate of just 23% against Twins pitchers this season — tied for 3rd lowest in MLB.

The Twins have allowed 1.62 runs per game (89/55) in late innings this season — tied for 4th highest in MLB.

Twins pitchers have allowed 52 stolen bases this season — 3rd most in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 13% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a miss rate of just 23% against White Sox pitchers this season — tied for 3rd lowest in MLB.

White Sox pitchers have walked 10% of batters this season — 5th highest in MLB.

White Sox pitchers have allowed an exit velocity over 100 MPH 344 times this season — 4th most in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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