• The White Sox are -105 favorites vs the Angels
• White Sox vs Angels Over / Under today: 9 Runs
• White Sox / Angels TV Channel: CHSN | ESUN | ANTV

The Chicago White Sox (-105) visit Angel Stadium of Anaheim to take on the Los Angeles Angels (-115) on May 5, 2026. First pitch is scheduled for 9:38 pm in Anaheim, CA.

This season, the White Sox are 17-18 against the spread (ATS), while the Angels are 17-19 ATS.

White Sox vs Angels Starting Pitchers Today:

• White Sox starting pitcher: Erick Fedde 0-3, 3.28 ERA
• Angels starting pitcher: Samuel Aldegheri 1-0, 5.41 ERA

White Sox vs. Angels Odds, Run Line, Over/Under & Moneyline

White Sox vs Angels Prediction for Today’s Game

Based on recent trends the model predicts the Angels will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Munetaka Murakami has hit the Home Runs Over in 7 of his last 10 away games (+21.70 Units / 217% ROI)
• Chase Meidroth has hit the Runs Over in 15 of his last 25 games (+12.60 Units / 50% ROI)
• Chase Meidroth has hit the Hits Over in 14 of his last 15 games (+12.50 Units / 44% ROI)
• Miguel Vargas has hit the RBIs Over in 6 of his last 7 away games (+10.30 Units / 147% ROI)
• Luisangel Acuna has hit the Total Bases Under in 11 of his last 15 away games (+9.75 Units / 65% ROI)

And here are some favorite MLB player prop bets for Angels players for Tuesday‘s game, looking at profitable historical betting trends:

Best Angels Player Prop Best Bets Today:

• Mike Trout has hit the RBIs Under in 14 of his last 15 games at home (+11.95 Units / 37% ROI)
• Josh Lowe has hit the Hits Under in 12 of his last 15 games at home (+11.20 Units / 75% ROI)
• Josh Lowe has hit the Hits Runs and RBIs Under in 13 of his last 15 games at home (+11.15 Units / 52% ROI)
• Jo Adell has hit the Singles Over in 17 of his last 25 games (+10.80 Units / 43% ROI)
• Nolan Schanuel has hit the Walks Under in 20 of his last 25 games (+10.70 Units / 22% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 10 of their last 11 away games (+9.20 Units / 72% ROI)
• The Chicago White Sox have covered the Run Line in 10 of their last 11 away games (+8.40 Units / 50% ROI)
• The Chicago White Sox have hit the Moneyline in 8 of their last 11 away games (+7.80 Units / 71% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 8 of their last 10 away games (+5.75 Units / 50% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 6 of their last 10 away games (+5.40 Units / 54% ROI)

Angels Best Bets Today:

• The Los Angeles Angels have hit the Team Total Under in 25 of their last 35 games at home (+13.65 Units / 33% ROI)
• The Los Angeles Angels have hit the Game Total Under in 13 of their last 19 games at home (+7.85 Units / 38% ROI)
• The Los Angeles Angels have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 25 games (+5.55 Units / 18% ROI)
• The Los Angeles Angels have covered the 1st Five Innings (F5) Run Line in 21 of their last 35 games (+4.20 Units / 10% ROI)
• The Los Angeles Angels have hit the 1st Five Innings (F5) Moneyline in 16 of their last 35 games (+3.70 Units / 9% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 19-16 against the Run Line (-3.55 Units / -6.97% ROI).

• 17-18 when betting on the Moneyline for +3.25 Units / 8.99% ROI
• 19-16 when betting on the total runs Over for +1.55 Units / 4.04% ROI
• 16-19 when betting on the total runs Under for -4.9 Units / -12.68% ROI

Angels Against the Spread (ATS) Record

Against the spread this season, the Angels are 17-19 against the Run Line (-7.65 Units / -15.84% ROI).

• 13-23 when betting on the Moneyline for -6.55 Units / -17.01% ROI
• 17-18 when betting on the total runs Over for -2.55 Units / -6.39% ROI
• 18-17 when betting on the total runs Under for -0.2 Units / -0.51% ROI

White Sox Keys to the Game vs. the Angels

The White Sox are just 59-18 (.766) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .872.

The White Sox are just 65-12 (.844) when leading entering the 8th inning since the 2025 season — 3rd lowest in MLB; League Avg: .906.

The White Sox were just 41-121 (.253) in the 2024 season — lowest in MLB; League Avg: .500.

The White Sox are just 74-102 (.420) when allowing 5 or more extra base hits since the 2025 season — 2nd lowest in MLB; League Avg: .534.

Angels Keys to the Game vs. the White Sox

The Angels are just 13-23 (.361) this season — lowest in MLB; League Avg: .500.

The Angels are just 0-14 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .144.

The Angels are just 12-3 (.800) when leading entering the 8th inning this season — tied for 3rd lowest in MLB; League Avg: .891.

The Angels are just 13-20 (.394) when allowing 5 or more extra base hits this season — 2nd lowest in MLB; League Avg: .532.

White Sox Hitting Stats & Trends

White Sox hitters have an OPS of just .671 (5,384 PA’s) against RHP since the 2025 season — lowest in MLB.

The White Sox are batting just .150 against division opponents this season — lowest in MLB.

White Sox hitters are slugging just .356 against RHP since the 2024 season — lowest in MLB.

White Sox hitters have an OPS of just .665 (3,493 PA’s) at home since the 2025 season — 2nd lowest in MLB.

Angels Hitting Stats & Trends

Angels hitters have struck out in 52% of their PA’s against LHP over the past seven days (5 games) — highest in MLB.

Angels hitters have struck out in 27% of their PA’s against RHP since the 2025 season — highest in MLB.

The Angels are batting just .142 with two-strikes since the 2025 season — lowest in MLB.

Angels hitters have struck out in 27% of their PA’s since the 2025 season — highest in MLB.

White Sox Pitching Stats & Trends

Opponents have a miss rate of just 23% against White Sox pitchers this season — 4th lowest in MLB.

White Sox pitchers walked 643 of 6,241 batters (10%) in the 2024 season — highest in MLB; League Avg: 8%.

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

White Sox pitchers have walked 10% of batters when facing the leadoff batter in the inning since the 2025 season — 3rd highest in MLB.

Angels Pitching Stats & Trends

Angels pitchers have walked 11% of batters when facing the leadoff batter in the inning since the 2025 season — highest in MLB.

Angels pitchers have walked 10% of batters since the 2025 season — highest in MLB.

Opponents have a miss rate of 28% against Angels pitchers this season — best in MLB.

Angels pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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