• The Astros are -150 favorites vs the White Sox
• White Sox vs Astros Over / Under today: 7.5 Runs
• White Sox / Astros TV Channel: PEAC | NBCS

The Chicago White Sox (+125) visit Daikin Park to take on the Houston Astros (-150) on September 30, 2026. First pitch is scheduled for 5:00 pm in Houston, TX.

This season, the White Sox are 85-78 against the spread (ATS), while the Astros are 84-79 ATS.

White Sox vs Astros Starting Pitchers Today:

• White Sox starting pitcher: Sean Burke 11-7, 3.34 ERA
• Astros starting pitcher: Hunter Brown 6-4, 3.18 ERA

White Sox vs. Astros Odds, Run Line, Over/Under & Moneyline

White Sox vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Wednesday‘s MLB game with 57.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Chase Meidroth has hit the Home Runs Over in 2 of his last 5 games (+19.00 Units / 380% ROI)
• Miguel Vargas has hit the Singles Over in 17 of his last 20 away games (+16.80 Units / 83% ROI)
• Andrew Benintendi has hit the Total Bases Under in 17 of his last 20 games (+16.05 Units / 65% ROI)
• Andrew Benintendi has hit the Hits Under in 15 of his last 20 games (+13.65 Units / 67% ROI)
• Miguel Vargas has hit the Walks Over in 15 of his last 25 away games (+10.70 Units / 42% ROI)

And here are some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Yainer Diaz has hit the Total Bases Over in 18 of his last 25 games (+16.00 Units / 56% ROI)
• Christian Walker has hit the Runs Under in 18 of his last 20 games at home (+14.45 Units / 41% ROI)
• Isaac Paredes has hit the Home Runs Over in 4 of his last 9 games (+13.90 Units / 154% ROI)
• Yainer Diaz has hit the Hits Over in 20 of his last 25 games (+12.70 Units / 26% ROI)
• Taylor Trammell has hit the Singles Under in 14 of his last 15 games at home (+11.15 Units / 34% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 31 of their last 45 away games (+14.30 Units / 26% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 50 games (+13.00 Units / 21% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 10 of their last 12 games (+8.15 Units / 48% ROI)
• The Chicago White Sox have hit the Game Total Over in 9 of their last 10 away games (+7.80 Units / 70% ROI)
• The Chicago White Sox have covered the Run Line in 10 of their last 14 games (+6.95 Units / 39% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Team Total Under in 17 of their last 21 games at home (+12.70 Units / 51% ROI)
• The Houston Astros have hit the Game Total Under in 15 of their last 21 games at home (+9.65 Units / 42% ROI)
• The Houston Astros have covered the 1st Five Innings (F5) Run Line in 16 of their last 23 games (+7.75 Units / 28% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 28 of their last 45 games (+7.60 Units / 14% ROI)
• The Houston Astros have covered the Run Line in 19 of their last 30 games (+7.35 Units / 18% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 91-69 against the Run Line (+7.75 Units / 3.41% ROI).

• 85-78 when betting on the Moneyline for +11.05 Units / 6.09% ROI
• 93-68 when betting on the total runs Over for +18.05 Units / 10.07% ROI
• 68-93 when betting on the total runs Under for -34.55 Units / -19.25% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 84-79 against the Run Line (-0.9 Units / -0.42% ROI).

• 81-82 when betting on the Moneyline for -12.65 Units / -6.38% ROI
• 80-72 when betting on the total runs Over for -0.1 Units / -0.06% ROI
• 72-80 when betting on the total runs Under for -15.7 Units / -8.82% ROI

White Sox Keys to the Game vs. the Astros

The White Sox are 15-6 (.714) when tied entering the 7th inning this season — 2nd best in MLB.

The White Sox are 12-7 (.632) when tied entering the 8th inning this season — 5th best in MLB.

The White Sox are 46-32 (.590) after a loss this season — 5th best in MLB.

The White Sox are just 155-104 (.598) when allowing 4 or fewer runs since the 2024 season — 2nd lowest in MLB.

Astros Keys to the Game vs. the White Sox

The Astros are 70-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Astros are 13-7 (.650) when tied entering the 8th inning this season — 3rd best in MLB.

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros are 144-2 (.986) when leading entering the 9th inning since the 2025 season — best in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have 151 extra-base hits out of 378 total hits (40%) against LHP this season — best in MLB.

White Sox hitters have 75 extra-base hits out of 155 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

White Sox hitters have grounded into 73 double plays in 1,175 opportunities (6%) this season — best in MLB.

White Sox hitters are slugging .611 on the first pitch of at-bats this season — 3rd best in MLB.

Astros Hitting Stats & Trends

Astros hitters have drawn walks in 13% of their PA’s with runners in scoring position this season — best in MLB.

Astros hitters are slugging .424 on the road this season — 2nd best in MLB.

Astros hitters have 48 extra-base hits out of 181 total hits (just 27%) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Astros are batting .246 with two outs this season — tied for 5th best in MLB.

White Sox Pitching Stats & Trends

The White Sox have won 46% of home games in which their opponents scored first this season — 3rd highest in MLB.

Opponents have a groundball rate of just 40% against White Sox pitchers this season — tied for 3rd lowest in MLB.

White Sox pitchers have allowed an average Exit Velocity of 89.2 MPH (4,095 batted balls) this season — tied for 4th highest in MLB.

The White Sox pitchers have allowed an average Exit Velocity of 89.2 MPH this season (4,095 balls in play) — tied for 4th highest in MLB

Astros Pitching Stats & Trends

Astros pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Astros pitchers have walked 10% of batters this season — tied for highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

The Astros have won just 28% of home games in which their opponents scored first this season — tied for 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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