• The Cubs are -145 favorites vs the White Sox
• White Sox vs Cubs Over / Under today: 8 Runs
• White Sox / Cubs TV Channel: MARQ | CHSN | WCIU

The Chicago White Sox (+118) visit Wrigley Field to take on the Chicago Cubs (-145) on August 19, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the White Sox are 65-60 against the spread (ATS), while the Cubs are 61-64 ATS.

White Sox vs Cubs Starting Pitchers Today:

• White Sox starting pitcher: Sean Newcomb 1-3, 2.53 ERA
• Cubs starting pitcher: Clay Holmes 5-5, 2.56 ERA

White Sox vs. Cubs Odds, Run Line, Over/Under & Moneyline

White Sox vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Wednesday‘s MLB game with 56.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Munetaka Murakami has hit the Total Bases Over in 19 of his last 25 games (+13.50 Units / 42% ROI)
• Chase Meidroth has hit the Home Runs Over in 2 of his last 10 games (+13.00 Units / 130% ROI)
• Munetaka Murakami has hit the Hits Over in 20 of his last 25 games (+11.40 Units / 29% ROI)
• Munetaka Murakami has hit the Singles Under in his last 10 games (+10.00 Units / 48% ROI)
• Munetaka Murakami has hit the Walks Over in 17 of his last 25 away games (+9.45 Units / 34% ROI)

And here are some favorite MLB player prop bets for Cubs players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Michael Conforto has hit the Runs Under in 17 of his last 20 games at home (+12.40 Units / 36% ROI)
• Seiya Suzuki has hit the Hits Runs and RBIs Over in 13 of his last 15 games at home (+10.90 Units / 59% ROI)
• Michael Conforto has hit the Total Bases Under in 15 of his last 20 games at home (+10.75 Units / 47% ROI)
• Pete Crow-Armstrong has hit the Home Runs Over in 4 of his last 7 games at home (+10.45 Units / 149% ROI)
• Nico Hoerner has hit the Singles Over in 19 of his last 25 games (+10.25 Units / 27% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 27 of their last 40 away games (+12.55 Units / 26% ROI)
• The Chicago White Sox have covered the Run Line in 30 of their last 50 games (+10.20 Units / 15% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 16 of their last 24 away games (+6.90 Units / 24% ROI)
• The Chicago White Sox have hit the Game Total Over in 24 of their last 40 away games (+6.65 Units / 15% ROI)
• The Chicago White Sox have hit the Team Total Over in 8 of their last 10 games (+5.75 Units / 48% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 32 of their last 50 games (+21.00 Units / 36% ROI)
• The Chicago Cubs have hit the Moneyline in 34 of their last 50 games (+14.05 Units / 21% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 28 of their last 45 games at home (+9.00 Units / 17% ROI)
• The Chicago Cubs have hit the Team Total Over in 30 of their last 50 games (+5.75 Units / 10% ROI)
• The Chicago Cubs have hit the Game Total Over in 28 of their last 50 games (+5.05 Units / 9% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 72-50 against the Run Line (+8.15 Units / 4.57% ROI).

• 65-60 when betting on the Moneyline for +12.05 Units / 8.96% ROI
• 71-52 when betting on the total runs Over for +14.1 Units / 10.31% ROI
• 52-71 when betting on the total runs Under for -26.55 Units / -19.21% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 61-64 against the Run Line (+0.55 Units / 0.37% ROI).

• 74-53 when betting on the Moneyline for +6.35 Units / 3.7% ROI
• 68-57 when betting on the total runs Over for +6 Units / 4.29% ROI
• 57-68 when betting on the total runs Under for -17.3 Units / -12.37% ROI

Cubs vs White Sox Home Run Prop Bets Today

Cubs vs White Sox Total Hits Prop Bets Today

Cubs vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Cubs

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox were just 40-103 (.280) when allowing 5 or more extra base hits in the 2024 season — lowest in MLB; League Avg: .538.

The White Sox were just 35-12 (.745) when leading entering the 8th inning in the 2024 season — lowest in MLB; League Avg: .899.

The White Sox were just 41-121 (.253) in the 2024 season — lowest in MLB; League Avg: .500.

Cubs Keys to the Game vs. the White Sox

The Cubs are 5-3 (.625) after a win this season — tied for 4th best in MLB.

The Cubs are 5-3 (.625) after a win since the 2025 season — tied for 4th best in MLB.

The Cubs were 48-6 (.889) when they had 10 or more hits in the 2025 season — best in MLB; League Avg: .743.

The Cubs were 40-9 (.816) when they scored in the first inning in the 2025 season — best in MLB; League Avg: .636.

White Sox Hitting Stats & Trends

White Sox hitters have 61 extra-base hits out of 126 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

White Sox hitters have grounded into 59 double plays in 888 opportunities (7%) this season — best in MLB.

White Sox hitters have struck out in 24% of their PA’s against RHP this season — 5th highest in MLB.

White Sox hitters are slugging .468 against pitchers who have thrown at least 80 pitches in a game this season — best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .356 (1,342 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .808 (1,342 PA’s) against LHP this season — best in MLB.

Cubs hitters are slugging .452 against LHP this season — best in MLB.

Cubs hitters have an OBP of .348 (2,497 PA’s) at home this season — best in MLB.

White Sox Pitching Stats & Trends

The White Sox have won 53% of home games in which their opponents scored first this season — 2nd highest in MLB.

Opponents have a groundball rate of just 40% against White Sox pitchers this season — tied for 3rd lowest in MLB.

White Sox pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

White Sox pitchers have an ERA of 3.38 (565.0 IP) at home this season — 3rd best in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .206 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have won 39% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB.

The Cubs have won 44% of games in which their opponents scored first this season — 3rd highest in MLB.

The Cubs pitchers have allowed division opponents to score first in 64% of their games this season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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