• The Diamondbacks are -155 favorites vs the White Sox
• White Sox vs Diamondbacks Over / Under today: 9 Runs
• White Sox / Diamondbacks TV Channel: CHSN | DBTV

The Chicago White Sox (+125) visit Chase Field to take on the Arizona Diamondbacks (-155) on April 23, 2026. First pitch is scheduled for 3:40 pm in Phoenix, AZ.

This season, the White Sox are 9-15 against the spread (ATS), while the Diamondbacks are 18-6 ATS.

White Sox vs Diamondbacks Starting Pitchers Today:

• White Sox starting pitcher: Davis Martin 3-1, 2.19 ERA
• Diamondbacks starting pitcher: Mike Soroka 4-0, 2.78 ERA

White Sox vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

White Sox vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Thursday‘s MLB game with 57.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Diamondbacks and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Thursday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Colson Montgomery has hit the Home Runs Over in 5 of his last 6 away games (+21.30 Units / 355% ROI)
• Colson Montgomery has hit the Singles Under in 14 of his last 15 games (+12.15 Units / 47% ROI)
• Edgar Quero has hit the Runs Under in his last 10 games (+10.00 Units / 45% ROI)
• Colson Montgomery has hit the RBIs Over in his last 6 away games (+9.90 Units / 165% ROI)
• Chase Meidroth has hit the Total Bases Under in 15 of his last 20 away games (+9.30 Units / 28% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Thursday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Ildemaro Vargas has hit the Home Runs Over in 3 of his last 7 games at home (+26.50 Units / 379% ROI)
• Ildemaro Vargas has hit the Hits Over in his last 15 games (+15.00 Units / 51% ROI)
• Ildemaro Vargas has hit the Total Bases Over in 12 of his last 15 games (+11.90 Units / 62% ROI)
• Jose Fernandez has hit the Singles Over in 13 of his last 15 games (+11.68 Units / 74% ROI)
• Ildemaro Vargas has hit the Runs Over in 8 of his last 10 games (+9.80 Units / 98% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 50 away games (+10.55 Units / 16% ROI)
• The Chicago White Sox have hit the Team Total Over in 30 of their last 50 away games (+8.45 Units / 15% ROI)
• The Chicago White Sox have hit the Game Total Over in 13 of their last 18 away games (+7.55 Units / 38% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 12 of their last 22 games (+5.70 Units / 26% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 5 of their last 6 games (+3.85 Units / 55% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 35 of their last 50 games (+19.95 Units / 35% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 26 of their last 45 games at home (+12.00 Units / 20% ROI)
• The Arizona Diamondbacks have covered the Run Line in 18 of their last 23 games (+11.55 Units / 35% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 27 of their last 45 games (+10.50 Units / 21% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 23 of their last 35 games at home (+9.95 Units / 23% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 11-13 against the Run Line (-8.55 Units / -24.36% ROI).

• 9-15 when betting on the Moneyline for -2.6 Units / -10.79% ROI
• 16-8 when betting on the total runs Over for +7.1 Units / 26.89% ROI
• 8-16 when betting on the total runs Under for -9.7 Units / -36.74% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 18-6 against the Run Line (+10.55 Units / 30.8% ROI).

• 14-10 when betting on the Moneyline for +5.6 Units / 21.01% ROI
• 15-8 when betting on the total runs Over for +6.3 Units / 23.68% ROI
• 8-15 when betting on the total runs Under for -8.2 Units / -31.3% ROI

Diamondbacks vs White Sox Home Run Prop Bets Today

Diamondbacks vs White Sox Total Hits Prop Bets Today

Diamondbacks vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Diamondbacks

The White Sox are just 88-41 (.682) when leading entering the 7th inning since the 2024 season — lowest in MLB; League Avg: .866.

The White Sox are just 63-7 (.900) when leading entering the 9th inning since the 2025 season — lowest in MLB; League Avg: .956.

The White Sox are just 51-126 (.288) on the road since the 2024 season — 2nd lowest in MLB; League Avg: .467.

The White Sox are just 55-18 (.753) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .875.

Diamondbacks Keys to the Game vs. the White Sox

The Diamondbacks are just 77-15 (.837) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .908.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks are 3-5 (.375) when trailing entering the 7th inning this season — best in MLB; League Avg: .129.

The Diamondbacks are just 70-20 (.778) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .875.

White Sox Hitting Stats & Trends

The White Sox have a winning percentage of just 34% at home since the 2024 season — lowest in MLB.

The White Sox have a winning percentage of just 29% on the road since the 2024 season — 2nd lowest in MLB.

The White Sox won only 33% of their road games in the 2025 season — tied for 2nd lowest in MLB.

White Sox hitters are slugging .466 against LHP this season — 3rd best in MLB.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters are slugging .717 in lefty-lefty matchups this season — best in MLB.

The Diamondbacks are batting .413 in lefty-lefty matchups this season — best in MLB.

Diamondbacks hitters have chased 48% of pitches out of the zone with two-strikes this season — highest in MLB.

Diamondbacks hitters struck out in just 19% of their PA’s against LHP in the 2025 season — 3rd best in MLB.

White Sox Pitching Stats & Trends

The White Sox have won just 9% of road games in which their opponents scored first since the 2024 season — lowest in MLB.

In games when their opponents have scored three or more runs in an inning, the White Sox won just 11% of the time since the 2024 season — lowest in MLB.

White Sox pitchers had a first-pitch strike rate of just 59% in the 2025 season — lowest in MLB.

White Sox pitchers have walked 14% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have walked 4% of batters when facing the leadoff batter in the inning this season — best in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 5th lowest in MLB.

Diamondbacks pitchers have walked 2% of batters when facing the leadoff batter in the inning over the past seven days (5 games) — best in MLB.

Diamondbacks pitchers have a strikeout rate of just 21% since the 2025 season — tied for 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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