• The White Sox are -115 favorites vs the Giants
• White Sox vs Giants Over / Under today: 7 Runs
• White Sox / Giants TV Channel: NSBA | CHSN

The Chicago White Sox (-115) visit Oracle Park to take on the San Francisco Giants (-105) on May 22, 2026. First pitch is scheduled for 10:15 pm in San Francisco, CA.

This season, the White Sox are 25-24 against the spread (ATS), while the Giants are 20-29 ATS.

White Sox vs Giants Starting Pitchers Today:

• White Sox starting pitcher: Davis Martin 6-1, 1.62 ERA
• Giants starting pitcher: Trevor McDonald 2-0, 2.37 ERA

White Sox vs. Giants Odds, Run Line, Over/Under & Moneyline

White Sox vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Friday‘s MLB game with 52.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Tristan Peters has hit the Home Runs Over in 2 of his last 4 games (+17.00 Units / 425% ROI)
• Chase Meidroth has hit the Runs Over in 16 of his last 25 games (+15.85 Units / 63% ROI)
• Chase Meidroth has hit the Hits Over in 14 of his last 15 away games (+12.75 Units / 46% ROI)
• Chase Meidroth has hit the Hits Runs and RBIs Over in 13 of his last 15 away games (+12.65 Units / 78% ROI)
• Colson Montgomery has hit the Singles Under in 17 of his last 20 away games (+11.55 Units / 33% ROI)

And here are some favorite MLB player prop bets for Giants players for Friday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Casey Schmitt has hit the Home Runs Over in 4 of his last 7 games at home (+20.50 Units / 293% ROI)
• Luis Arraez has hit the Singles Over in 21 of his last 25 games at home (+13.75 Units / 30% ROI)
• Rafael Devers has hit the Hits Over in 17 of his last 20 games (+11.00 Units / 31% ROI)
• Rafael Devers has hit the Total Bases Over in 15 of his last 20 games (+10.85 Units / 41% ROI)
• Matt Chapman has hit the Runs Under in 16 of his last 20 games (+8.95 Units / 24% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 21 of their last 30 games (+11.20 Units / 33% ROI)
• The Chicago White Sox have covered the Run Line in 21 of their last 30 games (+10.80 Units / 24% ROI)
• The Chicago White Sox have hit the Moneyline in 19 of their last 30 games (+10.25 Units / 33% ROI)
• The Chicago White Sox have hit the Game Total Over in 7 of their last 9 games (+5.95 Units / 61% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 9 of their last 12 games (+5.85 Units / 40% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Over in 25 of their last 40 games at home (+7.90 Units / 16% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 23 games at home (+6.40 Units / 25% ROI)
• The San Francisco Giants have hit the Moneyline in 9 of their last 14 games at home (+5.15 Units / 33% ROI)
• The San Francisco Giants have hit the Game Total Over in 24 of their last 45 games at home (+4.10 Units / 8% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 4 of their last 9 games (+1.45 Units / 16% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 28-20 against the Run Line (-0.15 Units / -0.21% ROI).

• 25-24 when betting on the Moneyline for +5.75 Units / 11.36% ROI
• 28-20 when betting on the total runs Over for +6.2 Units / 11.59% ROI
• 20-28 when betting on the total runs Under for -11.05 Units / -20.35% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 20-29 against the Run Line (-20 Units / -27.8% ROI).

• 20-30 when betting on the Moneyline for -7.55 Units / -14.03% ROI
• 22-25 when betting on the total runs Over for -5.45 Units / -9.88% ROI
• 25-22 when betting on the total runs Under for +0.9 Units / 1.64% ROI

Giants vs White Sox Home Run Prop Bets Today

Giants vs White Sox Total Hits Prop Bets Today

Giants vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Giants

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox are just 48-77 (.384) after a loss since the 2025 season — 2nd lowest in MLB; League Avg: .481.

The White Sox are just 96-41 (.701) when leading entering the 7th inning since the 2024 season — lowest in MLB; League Avg: .865.

The White Sox were just 40-103 (.280) when allowing 5 or more extra base hits in the 2024 season — lowest in MLB; League Avg: .538.

Giants Keys to the Game vs. the White Sox

The Giants are just 5-8 (.385) vs the bottom 10 runs allowed teams this season Today, they face the White Sox (24th runs allowed).

The Giants are just 0-23 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .137.

The Giants are just 0-26 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .055.

The Giants are just 14-5 (.737) when leading entering the 7th inning this season — 2nd lowest in MLB; League Avg: .863.

White Sox Hitting Stats & Trends

White Sox hitters have an OPS of .785 (496 PA’s) against LHP this season — 2nd best in MLB.

White Sox hitters are slugging .718 on the first pitch of at-bats this season — best in MLB.

White Sox hitters are slugging .451 against LHP this season — 2nd best in MLB.

White Sox hitters are slugging just .176 on pitches out of the zone this season — 5th lowest in MLB.

Giants Hitting Stats & Trends

Giants hitters have drawn walks in 6% of their PA’s against RHP this season — lowest in MLB.

Giants hitters have an OBP of just .290 (1,341 PA’s) against RHP this season — lowest in MLB.

Giants hitter’ K:BB ratio is 3.8 against RHP this season — highest in MLB.

Giants hitters have drawn walks in 6% of their PA’s this season — lowest in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 13% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a miss rate of just 23% against White Sox pitchers this season — 5th lowest in MLB.

White Sox pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

White Sox pitchers have walked 11% of batters this season — 5th highest in MLB.

Giants Pitching Stats & Trends

Giants pitchers have thrown at least two strikes in their first three pitches to 56% of opposing batters this season — lowest in MLB.

Giants pitchers have induced opposing hitters to ground into 48 double plays in 363 opportunities (13%) this season — best in MLB.

Opponents have a groundball rate of 47% against Giants pitchers this season — 2nd highest in MLB.

Giants pitchers have 47 three-pitch strikeouts this season — 2nd fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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