• The Guardians are -140 favorites vs the White Sox
• White Sox vs Guardians Over / Under today: 8 Runs
• White Sox / Guardians TV Channel: GDTV | WKYC | CHSN

The Chicago White Sox (+115) visit Progressive Field to take on the Cleveland Guardians (-140) on July 3, 2026. First pitch is scheduled for 7:10 pm in Cleveland, OH.

This season, the White Sox are 45-41 against the spread (ATS), while the Guardians are 42-45 ATS.

White Sox vs Guardians Starting Pitchers Today:

• White Sox starting pitcher: Anthony Kay 6-3, 4.50 ERA
• Guardians starting pitcher: Gavin Williams 9-4, 3.81 ERA

White Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

White Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Friday‘s MLB game with 57.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Sam Antonacci has hit the Home Runs Over in 3 of his last 7 away games (+22.10 Units / 316% ROI)
• Tristan Peters has hit the Hits Runs and RBIs Over in 19 of his last 25 away games (+13.45 Units / 43% ROI)
• Chase Meidroth has hit the Runs Over in 15 of his last 25 away games (+12.45 Units / 50% ROI)
• Miguel Vargas has hit the RBIs Under in his last 10 away games (+10.00 Units / 48% ROI)
• Tristan Peters has hit the Hits Over in 18 of his last 25 away games (+8.80 Units / 24% ROI)

And here are some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Chase DeLauter has hit the Walks Under in 17 of his last 20 games (+10.60 Units / 26% ROI)
• Chase DeLauter has hit the Hits Over in his last 10 games (+10.00 Units / 46% ROI)
• Rhys Hoskins has hit the Runs Under in 13 of his last 15 games (+9.70 Units / 38% ROI)
• Daniel Schneemann has hit the Total Bases Under in 17 of his last 25 games (+9.60 Units / 34% ROI)
• David Fry has hit the Home Runs Over in 2 of his last 5 games (+9.40 Units / 188% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 24 of their last 35 away games (+12.70 Units / 32% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 50 games (+12.60 Units / 21% ROI)
• The Chicago White Sox have hit the Game Total Over in 31 of their last 50 games (+12.30 Units / 23% ROI)
• The Chicago White Sox have hit the Moneyline in 28 of their last 50 games (+8.55 Units / 16% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 10 of their last 14 games (+5.55 Units / 32% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 23 of their last 50 games (+6.50 Units / 11% ROI)
• The Cleveland Guardians have hit the Team Total Under in 24 of their last 40 games (+6.20 Units / 13% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 11 games (+5.20 Units / 40% ROI)
• The Cleveland Guardians have hit the Game Total Over in 13 of their last 21 games at home (+4.10 Units / 18% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 10 of their last 16 games at home (+4.00 Units / 22% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 48-36 against the Run Line (+0.05 Units / 0.04% ROI).

• 45-41 when betting on the Moneyline for +10.7 Units / 11.77% ROI
• 50-34 when betting on the total runs Over for +12.75 Units / 13.56% ROI
• 34-50 when betting on the total runs Under for -21.45 Units / -22.54% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 42-45 against the Run Line (-5.9 Units / -5.17% ROI).

• 46-42 when betting on the Moneyline for +3.15 Units / 3.03% ROI
• 43-45 when betting on the total runs Over for -6.1 Units / -6.34% ROI
• 45-43 when betting on the total runs Under for -2.75 Units / -2.82% ROI

Guardians vs White Sox Home Run Prop Bets Today

Guardians vs White Sox Total Hits Prop Bets Today

Guardians vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Guardians

The White Sox are just 3-20 (.130) when allowing 10 or more hits this season — 5th lowest in MLB; League Avg: .246.

The White Sox are 7-32 (.179) when trailing entering the 7th inning this season — 4th best in MLB; League Avg: .139.

The White Sox are 8-3 (.727) when tied entering the 7th inning this season — 3rd best in MLB; League Avg: .500.

The White Sox are 23-17 (.575) after a loss this season — 5th best in MLB; League Avg: .484.

Guardians Keys to the Game vs. the White Sox

The Guardians are 15-2 (.882) when they’ve hit 2 or more home runs this season — 2nd best in MLB; League Avg: .704.

The Guardians are just 3-30 (.091) when trailing entering the 7th inning this season — tied for 5th lowest in MLB; League Avg: .139.

The Guardians are 99-8 (.925) when leading entering the 7th inning since the 2025 season — 2nd best in MLB; League Avg: .870.

The Guardians are 15-10 (.600) when tied entering the 8th inning since the 2025 season — 4th best in MLB; League Avg: .500.

White Sox Hitting Stats & Trends

White Sox hitters are slugging .639 on the first pitch of at-bats this season — 3rd best in MLB.

White Sox hitters have struck out in 24% of their PA’s this season — 5th highest in MLB.

White Sox hitters have 44 extra-base hits out of 92 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

White Sox hitters are slugging .431 against LHP this season — tied for 4th best in MLB.

Guardians Hitting Stats & Trends

The Guardians are batting just .218 on the road this season — lowest in MLB.

The Guardians are batting just .200 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Guardians hitters have an OBP of just .274 (378 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Guardians hitters are slugging just .347 against LHP this season — tied for 2nd lowest in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — tied for highest in MLB.

The White Sox have won 56% of home games in which their opponents scored first this season — 2nd highest in MLB.

White Sox pitchers have walked 10% of batters this season — 4th highest in MLB.

Opponents have a groundball rate of just 40% against White Sox pitchers this season — tied for 4th lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 30% in close and late situations this season — best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — 3rd best in MLB.

Guardians pitchers have a strikeout rate of 24% this season — 3rd best in MLB.

Guardians pitchers have a strikeout rate of 25% with runners in scoring position this season — tied for 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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