• The Guardians are -150 favorites vs the White Sox
• White Sox vs Guardians Over / Under today: 8.5 Runs
• White Sox / Guardians TV Channel: GDTV | CHSN

The Chicago White Sox (+125) visit Progressive Field to take on the Cleveland Guardians (-150) on September 15, 2026. First pitch is scheduled for 6:40 pm in Cleveland, OH.

This season, the White Sox are 77-73 against the spread (ATS), while the Guardians are 69-81 ATS.

White Sox vs Guardians Starting Pitchers Today:

• White Sox starting pitcher: Davis Martin 9-7, 4.06 ERA
• Guardians starting pitcher: Foster Griffin 15-5, 3.65 ERA

White Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

White Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 57.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Miguel Vargas has hit the Singles Over in 18 of his last 25 games (+14.80 Units / 59% ROI)
• Sam Antonacci has hit the Hits Under in 15 of his last 25 away games (+14.15 Units / 53% ROI)
• Munetaka Murakami has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+11.50 Units / 37% ROI)
• Munetaka Murakami has hit the Total Bases Under in 18 of his last 25 games (+10.55 Units / 34% ROI)
• Miguel Vargas has hit the Walks Over in 12 of his last 20 away games (+9.75 Units / 49% ROI)

And here are some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 2 of his last 5 games at home (+17.00 Units / 340% ROI)
• Jose Ramirez has hit the RBIs Under in 18 of his last 20 games (+13.90 Units / 34% ROI)
• Travis Bazzana has hit the Runs Under in 17 of his last 20 games at home (+11.85 Units / 31% ROI)
• Jose Ramirez has hit the Total Bases Under in 13 of his last 15 games (+10.40 Units / 46% ROI)
• Jose Ramirez has hit the Walks Under in 13 of his last 15 games at home (+8.95 Units / 31% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 27 of their last 40 away games (+11.25 Units / 23% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 50 away games (+10.05 Units / 16% ROI)
• The Chicago White Sox have hit the Team Total Under in 11 of their last 16 games (+5.20 Units / 28% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 15 of their last 35 away games (+4.65 Units / 13% ROI)
• The Chicago White Sox have hit the Moneyline in 16 of their last 30 away games (+4.05 Units / 13% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Game Total Over in 10 of their last 16 games (+3.55 Units / 21% ROI)
• The Cleveland Guardians have hit the Moneyline in 15 of their last 24 games (+3.35 Units / 10% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 18 games (+3.30 Units / 16% ROI)
• The Cleveland Guardians have hit the Team Total Under in 5 of their last 7 games at home (+3.00 Units / 41% ROI)
• The Cleveland Guardians have covered the Run Line in 3 of their last 6 games (+0.45 Units / 6% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 82-65 against the Run Line (+1.8 Units / 0.85% ROI).

• 77-73 when betting on the Moneyline for +10 Units / 6.12% ROI
• 84-64 when betting on the total runs Over for +13.45 Units / 8.16% ROI
• 64-84 when betting on the total runs Under for -28.65 Units / -17.35% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 69-81 against the Run Line (-17.85 Units / -9.3% ROI).

• 76-75 when betting on the Moneyline for -8.5 Units / -4.52% ROI
• 72-78 when betting on the total runs Over for -12.65 Units / -7.71% ROI
• 78-72 when betting on the total runs Under for -2.15 Units / -1.28% ROI

White Sox Keys to the Game vs. the Guardians

The White Sox are 42-31 (.575) after a loss this season — 5th best in MLB.

The White Sox are just 29-14 (.674) when they’ve had 10 or more hits this season — 3rd lowest in MLB.

The White Sox are 15-5 (.750) when tied entering the 7th inning this season — 2nd best in MLB.

The White Sox are 41-22 (.651) vs bottom 10 scoring offenses this season Today, they face the Guardians (27th in runs scored).

Guardians Keys to the Game vs. the White Sox

The Guardians are 32-18 (.640) when tied entering the 8th inning since the 2024 season — 2nd best in MLB.

The Guardians were 82-0 (1.000) when leading entering the 9th inning in the 2024 season — best in MLB; League Avg: .949.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

White Sox Hitting Stats & Trends

White Sox hitters have 69 extra-base hits out of 144 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The White Sox are 44-19 (.698) against the run line (25.3% ROI) vs bottom 10 scoring offenses this season Today, they face the Guardians (27th in runs scored).

The White Sox are batting just .227 on the road this season — lowest in MLB.

The White Sox are batting just .235 this season — tied for 4th lowest in MLB.

Guardians Hitting Stats & Trends

Guardians hitters are slugging just .374 this season — 2nd lowest in MLB.

Guardians hitters have an OPS of just .653 (1,783 PA’s) in innings 7-9 this season — lowest in MLB.

The Guardians are batting just .226 against LHP this season — 2nd lowest in MLB.

Guardians hitters have an OPS of just .657 (1,734 PA’s) against LHP this season — 3rd lowest in MLB.

White Sox Pitching Stats & Trends

Opponents have a groundball rate of just 40% against White Sox pitchers this season — 3rd lowest in MLB.

White Sox pitchers have an ERA of 3.12 (383.1 IP) against division opponents this season — 2nd best in MLB.

The White Sox have won 47% of home games in which their opponents scored first this season — 2nd highest in MLB.

The White Sox have allowed 1.10 runs per game (165/150) in late innings this season — 3rd best in MLB.

Guardians Pitching Stats & Trends

Opponents have a miss rate of 27% against Guardians pitchers this season — 4th best in MLB.

Guardians pitchers have a strikeout rate of 30% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 28% in late innings this season — best in MLB.

Guardians pitchers have a strikeout rate of 46% with two-strikes this season — 4th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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