• The Yankees are -125 favorites vs the Diamondbacks
• Yankees vs Diamondbacks Over / Under today: 8 Runs
• Yankees / Diamondbacks TV Channel: DBTV | YES

The New York Yankees (-125) visit Chase Field to take on the Arizona Diamondbacks (+105) on September 18, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the Yankees are 88-64 against the spread (ATS), while the Diamondbacks are 78-70 ATS.

Yankees vs Diamondbacks Starting Pitchers Today:

• Yankees starting pitcher: Gerrit Cole 8-9, 3.69 ERA
• Diamondbacks starting pitcher: Eduardo Rodriguez 15-6, 2.62 ERA

Yankees vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

Yankees vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Yankees will win Friday‘s MLB game with 55.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Yankees players for Friday‘s game, looking at profitable historical betting trends:

Best Yankees Player Prop Bets Today:

• Heliot Ramos has hit the Runs Under in 22 of his last 25 games (+16.90 Units / 38% ROI)
• Heliot Ramos has hit the Hits Runs and RBIs Under in 21 of his last 25 games (+16.25 Units / 51% ROI)
• Cody Bellinger has hit the Home Runs Over in 4 of his last 8 games (+14.80 Units / 185% ROI)
• Aaron Judge has hit the Hits Under in 14 of his last 20 games (+13.90 Units / 56% ROI)
• Cody Bellinger has hit the Total Bases Over in 17 of his last 25 games (+12.75 Units / 48% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Friday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Nolan Arenado has hit the Home Runs Over in 5 of his last 10 games (+26.20 Units / 262% ROI)
• Lars Nootbaar has hit the Runs Under in 21 of his last 25 games (+15.85 Units / 45% ROI)
• Eduardo Rodriguez has hit the Earned Runs Under in 20 of his last 25 games (+14.70 Units / 51% ROI)
• Gabriel Moreno has hit the Total Bases Over in 17 of his last 25 games (+13.20 Units / 53% ROI)
• Gabriel Moreno has hit the RBIs Over in 14 of his last 25 games (+12.60 Units / 50% ROI)

Yankees Best Bets Today:

• The New York Yankees have covered the Run Line in 22 of their last 35 games (+14.25 Units / 35% ROI)
• The New York Yankees have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+9.25 Units / 12% ROI)
• The New York Yankees have hit the Moneyline in 31 of their last 50 away games (+8.65 Units / 14% ROI)
• The New York Yankees have hit the Game Total Over in 16 of their last 24 games (+8.45 Units / 32% ROI)
• The New York Yankees have covered the 1st Five Innings (F5) Run Line in 14 of their last 21 away games (+6.90 Units / 28% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 20 of their last 24 games (+15.65 Units / 50% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 16 of their last 23 games (+8.40 Units / 33% ROI)
• The Arizona Diamondbacks have hit the Team Total Under in 14 of their last 22 games (+4.05 Units / 15% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 24 of their last 45 games (+1.05 Units / 2% ROI)
• The Arizona Diamondbacks have covered the Run Line in 11 of their last 21 games at home (+0.95 Units / 4% ROI)

Yankees Against the Spread (ATS) Record

Against the spread this season, the Yankees are 77-74 against the Run Line (+12.3 Units / 7.13% ROI).

• 88-64 when betting on the Moneyline for -2.3 Units / -1.02% ROI
• 68-79 when betting on the total runs Over for -19.3 Units / -11.51% ROI
• 79-68 when betting on the total runs Under for +4.45 Units / 2.67% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 78-70 against the Run Line (-2.9 Units / -1.43% ROI).

• 80-73 when betting on the Moneyline for +5.75 Units / 3.2% ROI
• 64-83 when betting on the total runs Over for -27.35 Units / -16.19% ROI
• 83-64 when betting on the total runs Under for +13.15 Units / 7.84% ROI

Yankees Keys to the Game vs. the Diamondbacks

The Yankees are 52-6 (.897) when they’ve hit 2 or more home runs this season — best in MLB.

The Yankees are 38-4 (.905) when they’ve had 10 or more hits this season — best in MLB.

The Yankees are 57-6 (.905) when scoring 5 or more runs this season — best in MLB.

The Yankees are 17-20 (.459) when allowing 2 or more home runs this season — 2nd best in MLB.

Diamondbacks Keys to the Game vs. the Yankees

The Diamondbacks are 67-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks were just 61-17 (.782) when leading entering the 7th inning in the 2025 season — 2nd lowest in MLB; League Avg: .875.

The Diamondbacks were just 67-13 (.838) when leading entering the 8th inning in the 2025 season — tied for 2nd lowest in MLB; League Avg: .909.

Yankees Hitting Stats & Trends

Yankees hitters have an OPS of .777 (1,821 PA’s) in innings 7-9 this season — best in MLB.

Yankees hitters have struck out in 25% of their PA’s against RHP this season — 3rd highest in MLB.

The Yankees are batting just .154 with two-strikes this season — 2nd lowest in MLB.

The Yankees are batting just .127 on pitches out of the zone this season — lowest in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .274 against LHP this season — best in MLB.

Diamondbacks hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Diamondbacks hitters have an OPS of .777 (1,613 PA’s) against LHP this season — 2nd best in MLB.

Diamondbacks hitters have a swing rate of just 25% on the first pitch of at-bats this season — lowest in MLB.

Yankees Pitching Stats & Trends

Yankees pitchers have an ERA of 2.88 (691.0 IP) on the road this season — best in MLB.

The Yankees have allowed 3.38 runs per game (264/78) on the road this season — best in MLB.

Yankees pitchers have an ERA of 3.20 (1362.0 IP) this season — best in MLB.

Yankees pitchers have allowed innings of 3+ runs in 4% of innings played this season — lowest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 19% this season — 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 38% with two-strikes this season — 3rd lowest in MLB.

Diamondbacks pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — tied for 4th best in MLB.

The Diamondbacks pitchers have allowed division opponents to score first in just 37% of their games this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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