Cardinals vs Giants Prediction, Odds & Best Prop Bets – NFL, Week 4

• The Cardinals are +2.5 point favorites vs the Giants
• Total (Over/Under): 43.5 points
• Watch this game on CBS

The Arizona Cardinals (1-2-0) visit MetLife Stadium to take on the New York Giants (2-1-0) on Oct. 4. Kickoff is scheduled for 1:00 pm in East Rutherford, NJ.

The Cardinals are betting favorites in this matchup, with the spread sitting at +2.5 (-175).

The Cardinals vs. Giants Over/Under is 43.5 total points for the game.

Bet now on Giants vs Cardinals & all NFL games with BetMGM

Cardinals vs. Giants Odds, Spread, Over/Under

Cardinals vs. Giants Prediction

The winning team model predicts the Giants will win this game with 51.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Cardinals vs Giants Spread Prediction

Based on recent against-the-spread trends, the model predicts the Giants will cover the spread with 51.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

Bet now on Giants vs Cardinals and all NFL games with BetMGM

We’ve highlighted some favorite NFL player prop bets for Cardinals players this game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today

• Jacoby Brissett has hit the TD Passes Over in 11 of his last 15 games (+10.15 Units / 62% ROI)
• Jacoby Brissett has hit the Passing Yards Over in 12 of his last 15 games (+8.55 Units / 50% ROI)
• Trey McBride has hit the Receptions Over in 12 of his last 16 games (+7.80 Units / 42% ROI)
• Elijah Higgins has hit the Receptions Over in 7 of his last 10 games (+5.90 Units / 53% ROI)
• Michael Wilson has hit the Receiving Yards Over in 11 of his last 16 games (+5.30 Units / 29% ROI)

And here are some top NFL player prop bets for Giants players for this matchup, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today

• Theo Johnson has hit the Receptions Under in 11 of his last 13 games (+8.85 Units / 56% ROI)
• J.J. McCarthy has hit the Completions Under in his last 6 games (+6.00 Units / 86% ROI)
• Isaiah Likely has hit the Longest Reception Under in 10 of his last 14 games (+5.55 Units / 35% ROI)
• J.J. McCarthy has hit the Pass Attempts Under in his last 5 games (+5.00 Units / 88% ROI)
• Theo Johnson has hit the Receiving Yards Under in 5 of his last 6 games at home (+3.90 Units / 57% ROI)

First Touchdown Scorer Bet for Giants vs Cardinals

Cardinals Best Bets:

• The Arizona Cardinals have hit the 3Q Game Total Over in 12 of their last 16 games (+7.15 Units / 36% ROI)
• The Arizona Cardinals have hit the 3Q Moneyline in 5 of their last 9 away games (+5.95 Units / 66% ROI)
• The Arizona Cardinals have hit the Team Total Over in 8 of their last 10 away games (+5.70 Units / 48% ROI)
• The Arizona Cardinals have hit the 4Q Game Total Over in 11 of their last 16 games (+5.50 Units / 31% ROI)
• The Arizona Cardinals have covered the 3Q Spread in 7 of their last 9 away games (+4.75 Units / 44% ROI)

Giants Best Bets:

• The New York Giants have covered the 3Q Spread in 13 of their last 16 games (+9.50 Units / 47% ROI)
• The New York Giants have hit the 1H Moneyline in 11 of their last 19 games (+9.40 Units / 43% ROI)
• The New York Giants have hit the 3Q Game Total Under in 12 of their last 16 games (+7.80 Units / 42% ROI)
• The New York Giants have hit the 1Q Moneyline in 10 of their last 18 games (+6.75 Units / 33% ROI)
• The New York Giants have hit the 1H Team Total Over in 12 of their last 17 games (+6.30 Units / 32% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 2-1 (+0.9 Units / 27.27% ROI).

• Cardinals are 1-2 when betting on the Moneyline for +1.8 Units / 60% ROI
• Cardinals are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
• CardinalsCardinalsCardinals are 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Giants Against the Spread (ATS) Record

Against the spread this NFL season, the Giants are 2-1 (+0.9 Units / 27.27% ROI).

• Giants are 2-1 when betting on the Moneyline for +1.5 Units / 44.12% ROI
• Giants are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
• Giants are 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Arizona Cardinals: Keys to the Game vs. the New York Giants

The Cardinals are winless (0-13) after a loss since the 2025 season — worst in NFL; League Avg: .427.

The Cardinals are 1-8 (.111) at home since the 2025 season — 2nd-worst in NFL; League Avg: .544.

The Cardinals are 1-7 (.125) when within 7 points entering the 4th quarter since the 2025 season — worst in NFL; League Avg: .497.

The Cardinals are 1-11 (.083) when allowing 120 or more rushing yards since the 2025 season — worst in NFL; League Avg: .341.

New York Giants: Keys to the Game vs. the Arizona Cardinals

Giants are 2-13 (.133) when allowing 100 yards rushing or more (2nd-worst in NFL) and .800 when allowing less than 100 yards rushing since the 2025 season (10th-best in NFL).

The Giants are winless (0-9) when throwing at least 1 interception since the 2025 season — worst in NFL; League Avg: .343.

The Giants are 1-10 (.091) when allowing 5 or more explosive passes since the 2025 season — T-2nd-worst in NFL; League Avg: .430.

The Giants are winless (0-12) when allowing 22 or more points since the 2025 season — T-worst in NFL; League Avg: .269.

Additional Matchup Notes for Arizona Cardinals vs. New York Giants

Giants TEs have gained 11.8 Yards Per Reception since the 2025 season — T-4th-best in NFL. The Cardinals have allowed 11.0 Yards Per Reception to TEs since the 2025 season — T-5th-worst in NFL.

The Giants rushed the ball on 55.2% of plays from scrimmage last week — 3rd-highest in NFL. The Cardinals allowed 6.4 yards per carry last week — 2nd-worst in NFL.

The Giants have been successful on just 32.8% of plays they have run against a stacked front since the 2025 season — 2nd-worst in NFL. The Cardinals have allowed a success rate of just 38.5% with a stacked front since the 2025 season — 2nd-best in NFL.

The Cardinals allowed opponents to pressure their QB on 15.4% of pass attempts last week — 4th-best in NFL. The Giants had pressured opposing QBs on just 8.3% of passing plays last week — 2nd-worst in NFL.

The Cardinals have allowed opponents to pressure their QB on 20.5% of pass attempts this season — T-4th-best in NFL. The Giants have pressured opposing QBs on just 9.9% of passing plays this season — worst in NFL.

The Cardinals have averaged 0.52 epa per play against a light rush since the 2025 season — T-3rd-best in NFL. The Giants have allowed 0.55 epa per play with a light rush since the 2025 season — 4th-worst in NFL.

Arizona Cardinals Offense: Important Stats

The Cardinals have completed passes for 20+ yards on just 2 of their 117 total passing attempts (2%) this season — worst in NFL; League Avg: 9%.

The Cardinals have run the ball on 34% of plays (438 carries/1,274 plays) since the 2025 season — lowest in NFL; League Avg: 42%.

The Cardinals have gone three and out 4 times in the 1st quarter since the 2025 season — T-fewest in NFL.

The Cardinals have averaged just 4.2 yards per play on motion plays this season — T-worst in NFL; League Avg: 5.7.

New York Giants Offense: Important Stats

The Giants have completed passes for 20+ yards on just 2 of their 83 total passing attempts (2%) this season — 2nd-worst in NFL; League Avg: 9%.

The Giants have turned the ball over on downs 10 times in the red zone since the 2025 season — most in NFL.

The Giants have run successful plays on 26% of rush attempts against a stacked front since the 2025 season — worst in NFL; League Avg: 46%.

The Giants ran successful plays on 27% of plays on first read passes in Week 3 — worst in NFL; League Avg: 55%.

Arizona Cardinals Defense: Important Stats

The Cardinals defense have allowed 13.0 yards per play open coverage this season — worst in NFL; League Avg: 9.7.

The Cardinals defense allowed 19.8 yards per completion (297 yards/15 completions) in Week 3 — worst in NFL; League Avg: 11.0.

23% of the plays run against the Cardinals have been in the red zone in the 2nd half since the 2025 season — worst in NFL; League Avg: 16%.

The Cardinals defense allowed 11.5 yards from scrimmage per touch (437 yards / 38 touches) in Week 3 — worst in NFL; League Avg: 7.3.

New York Giants Defense: Important Stats

The Giants defense has sacked opposing QBs on just 1% of pass attempts (1/102) this season — 2nd-worst in NFL; League Avg: 6%.

The Giants defense allowed successful plays on 8% of pass attempts in the 1st half in Week 3 — best in NFL; League Avg: 45%.

The Giants defense allowed successful plays on 10% of plays in the 1st half in Week 3 — best in NFL; League Avg: 43%.

The Giants defense forced three and outs on 56% of opponent drives in Week 3 — best in NFL; League Avg: 20%.

Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on Giants vs Cardinals and all NFL games with BetMGM

More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

More NFL Odds at BetMGM

If you’re looking for more NFL odds, check out the sportsbook’s betting markets throughout the year.

From futures like Rams Super Bowl odds and Lions odds to make the playoffs to game odds like spread, money lines, and totals, there’s never a break in the action.

Log in to your BetMGM account today — or sign up for a new account via the online sportsbook or BetMGM iOS app or BetMGM Android app — to start betting!