Alabama vs. LSU Odds: Week 10 NCAA Football Betting

LSU running back Caden Durham carrie the ball against Auburn during the second half of an NCAA college football game, Saturday, Oct. 24, 2026, in Auburn, Ala.
(AP Photo/Butch Dill)
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For years, the rivalry between Alabama and LSU dominated the SEC West.

Divisions are dead in the SEC, but this week’s showdown between the Tigers and Tide will still have major College Football Playoff implications. The winner will remain alive for an at-large bid, while the loser will suffer a third loss and likely be out of the mix. 

BetMGM has NCAA football odds available for all the Week 10 college football action. 

Alabama vs. LSU Odds

  • Point Spread: LSU -5.5
  • Moneyline: LSU -220  |  Alabama +180
  • Total: 52.5

Alabama vs. LSU: Preview & Notes

Since Lane Kiffin’s Tigers lost at Ole Miss in Week 3, they’ve gone 4-1 outright with three wins by at least 28 points. The only loss was at Kentucky, where the Wildcats won with a 2-point conversion at the end of overtime. 

That explains why LSU is a decent-sized favorite over visiting Alabama, which ranks 12th nationally in offensive success rate.

LSU ranks No. 1 in adjusted EPA per play and has one of the best-suited defensive backfields to challenge Keelon Russell. It ranks second nationally with -0.24 EPA/pass defended. 

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.