Florida vs. Missouri Odds: Week 5 NCAA Football Betting

Missouri cornerback Toriano Pride Jr. (2) walks the sideline during the second half of the Gator Bowl NCAA college football game in Jacksonville, Fla., Saturday, Dec. 27, 2025.
(AP Photo/Gary McCullough)
Odds Boost This Weekend

Florida jumped into the AP Top 10 after dumping 52 points on Ole Miss over the weekend. Now, the Gators hit the road for a second straight top 25 opponent.

This time, it’s Missouri that can play spoiler to the hot team that just scored a big win, just as Florida did last week to Ole Miss.

BetMGM has NCAA football odds available for all the Week 5 college football action. 

Florida vs. Missouri Odds

  • Point Spread: Florida -5
  • Moneyline: Florida -210  |  Missouri +170
  • Total: 56.5

Florida vs. Missouri: Preview & Notes

Since 2020, Florida is 8-14 in SEC road games, highlighting just how powerful the Gators’ home-field advantage can be in the Swamp. 

After a statement win like Florida had on Saturday, this is a natural letdown spot for Florida. And for Missouri, this is a bounce-back opportunity after losing at Mississippi State. A loss would drop the Tigers to 0-2 in the SEC, so expect a strong outing from Missouri.

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.