Ohio State vs. Indiana Odds: Week 7 NCAA Football Betting

A rematch of last year’s Big Ten championship game will be one of the month’s most compelling college football games.

Indiana will put its 22-game winning streak on the line when it hosts Ryan Day’s Ohio State juggernaut in Bloomington. 

BetMGM has NCAA football odds available for all the Week 7 college football action. 

Ohio State vs. Indiana Odds

• Point Spread: Ohio State -3.5
• Moneyline: Ohio State -185  |  Indiana +150
• Total: 51.5

Ohio State vs. Indiana: Preview & Notes

Curt Cignetti’s 2026 team just doesn’t appear to have the same unbeatable quality as last year’s, which explains why the reigning national champions are home dogs to one of the programs they beat en route to the title.

Recent games against Nebraska and Northwestern pushed Indiana to the brink. Obviously, Ohio State will be a taller task.

The key matchup may be Ohio State’s passing game, which runs through All-American receiver Jeremiah Smith, against Indiana’s pass defense, which ranks 76th in EPA/play. 

Good teams can throw on the Hoosiers, and it’s not clear that Josh Hoover can match scores against other elite offenses.