• The Blue Jays are -110 favorites vs the Orioles
• Blue Jays vs Orioles Over / Under today: 7.5 Runs
• Blue Jays / Orioles TV Channel: MASN | RSN | TVA

The Toronto Blue Jays (-110) visit Oriole Park at Camden Yards to take on the Baltimore Orioles (-110) on September 21, 2026. First pitch is scheduled for 6:35 pm in Baltimore, MD.

This season, the Blue Jays are 77-79 against the spread (ATS), while the Orioles are 81-74 ATS.

Blue Jays vs Orioles Starting Pitchers Today:

• Blue Jays starting pitcher: Trey Yesavage 5-5, 3.67 ERA
• Orioles starting pitcher: Shane Baz 6-15, 4.09 ERA

Blue Jays vs. Orioles Odds, Run Line, Over/Under & Moneyline

Blue Jays vs Orioles Prediction for Today’s Game

Based on recent trends the model predicts the Orioles will win Monday‘s MLB game with 52.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Blue Jays vs Orioles and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Blue Jays players for Monday‘s game, looking at profitable historical betting trends:

Best Blue Jays Player Prop Bets Today:

• Josh Smith has hit the Home Runs Over in 3 of his last 8 away games (+21.00 Units / 262% ROI)
• Alejandro Kirk has hit the Singles Over in 22 of his last 25 games (+18.00 Units / 55% ROI)
• Kazuma Okamoto has hit the Hits Over in 20 of his last 25 away games (+10.50 Units / 24% ROI)
• Andrés Giménez has hit the Runs Under in 17 of his last 20 games (+10.45 Units / 23% ROI)
• Kazuma Okamoto has hit the Hits Runs and RBIs Over in 17 of his last 25 away games (+8.95 Units / 30% ROI)

And here are some favorite MLB player prop bets for Orioles players for Monday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Best Bets Today:

• Gunnar Henderson has hit the Hits Runs and RBIs Under in 17 of his last 20 games at home (+13.60 Units / 53% ROI)
• Gunnar Henderson has hit the Runs Under in 20 of his last 25 games at home (+12.40 Units / 30% ROI)
• Samuel Basallo has hit the Total Bases Under in 18 of his last 25 games (+10.75 Units / 33% ROI)
• Samuel Basallo has hit the Hits Under in 16 of his last 25 games (+10.75 Units / 38% ROI)
• Christian Encarnacion-Strand has hit the Singles Under in 16 of his last 20 games at home (+10.30 Units / 35% ROI)

Blue Jays Best Bets Today:

• The Toronto Blue Jays have hit the Moneyline in 29 of their last 50 games (+8.80 Units / 14% ROI)
• The Toronto Blue Jays have covered the Run Line in 29 of their last 50 games (+8.55 Units / 14% ROI)
• The Toronto Blue Jays have hit the Game Total Over in 30 of their last 50 away games (+8.40 Units / 15% ROI)
• The Toronto Blue Jays have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 35 away games (+5.20 Units / 13% ROI)
• The Toronto Blue Jays have covered the 1st Five Innings (F5) Run Line in 23 of their last 40 games (+5.15 Units / 11% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 45 games at home (+13.15 Units / 24% ROI)
• The Baltimore Orioles have hit the Team Total Under in 26 of their last 40 games at home (+10.75 Units / 23% ROI)
• The Baltimore Orioles have hit the Game Total Under in 16 of their last 24 games at home (+8.50 Units / 32% ROI)
• The Baltimore Orioles have covered the Run Line in 5 of their last 6 games (+4.55 Units / 52% ROI)
• The Baltimore Orioles have covered the 1st Five Innings (F5) Run Line in 20 of their last 35 games (+2.10 Units / 5% ROI)

Blue Jays Against the Spread (ATS) Record

Against the spread this season, the Blue Jays are 78-77 against the Run Line (-3.8 Units / -1.91% ROI).

• 77-79 when betting on the Moneyline for -12.4 Units / -6.41% ROI
• 80-72 when betting on the total runs Over for +1.25 Units / 0.73% ROI
• 72-80 when betting on the total runs Under for -15.85 Units / -9.22% ROI

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 81-74 against the Run Line (+0.25 Units / 0.12% ROI).

• 75-81 when betting on the Moneyline for -12.1 Units / -6.64% ROI
• 78-74 when betting on the total runs Over for -3.35 Units / -1.94% ROI
• 74-78 when betting on the total runs Under for -10.8 Units / -6.32% ROI

Blue Jays Keys to the Game vs. the Orioles

The Blue Jays are just 7-57 (.109) when allowing 5 or more runs this season — lowest in MLB.

The Blue Jays are just 13-36 (.265) when their opponents score in the first inning this season — 2nd lowest in MLB.

The Blue Jays are just 7-64 (.099) when trailing entering the 7th inning this season — 5th lowest in MLB.

The Blue Jays were 12-53 (.185) when trailing entering the 8th inning in the 2025 season — best in MLB; League Avg: .090.

Orioles Keys to the Game vs. the Blue Jays

The Orioles are just 36-42 (.462) at home this season — 5th lowest in MLB.

The Orioles were 36-10 (.783) when they scored in the first inning in the 2024 season — 2nd best in MLB; League Avg: .641.

The Orioles are just 14-22 (.389) when tied entering the 8th inning since the 2024 season — 3rd lowest in MLB.

The Orioles were just 10-67 (.130) when they allowed 5 or more runs in the 2025 season — 4th lowest in MLB; League Avg: .202.

Blue Jays Hitting Stats & Trends

The Blue Jays are batting .197 with two-strikes this season — best in MLB.

Blue Jays hitters have chased 42% of pitches out of the zone in lefty-lefty matchups this season — highest in MLB.

Blue Jays hitters have an OPS of just .652 (1,729 PA’s) against LHP this season — lowest in MLB.

Blue Jays hitters have an OBP of just .295 (1,729 PA’s) against LHP this season — 2nd lowest in MLB.

Orioles Hitting Stats & Trends

Orioles hitters have struck out in 26% of their PA’s against LHP this season — highest in MLB.

Orioles hitters are slugging just .481 on the first pitch of at-bats this season — 2nd lowest in MLB.

Orioles hitters have an OPS of just .661 (1,802 PA’s) in innings 7-9 this season — 4th lowest in MLB.

The Orioles are batting just .157 with two-strikes this season — tied for 3rd lowest in MLB.

Blue Jays Pitching Stats & Trends

Blue Jays pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 5th highest in MLB.

The Blue Jays pitchers have allowed an average Exit Velocity of just 87.7 MPH this season (3,853 balls in play) — best in MLB

Blue Jays pitchers have allowed an average Exit Velocity of 87.7 MPH (3,853 batted balls) this season — best in MLB.

Blue Jays pitchers have walked 10% of batters this season — tied for 5th highest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers have allowed a run 35% of the time after their offense scores this season — 3rd highest in MLB.

Orioles pitchers has induced two-strike counts to 51% of batters they faced (3,016/5,972 PA’s) this season — 4th lowest in MLB.

Orioles pitchers are throwing just 3.83 pitches per plate appearance this season — 5th lowest in MLB.

Orioles pitchers walked 10% of batters when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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