Blue Jays vs Yankees Prediction, Odds & Player Prop Bets Today – MLB, May 21

New York Yankees' Jazz Chisholm Jr. reacts after connecting for a solo home run against the Toronto Blue Jays during the fifth inning of Game 3 of baseball's American League Division Series, Tuesday, Oct. 7, 2025, in New York.
(AP Photo/Frank Franklin II)
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The Toronto Blue Jays (+140) visit Yankee Stadium to take on the New York Yankees (-170) on May 21, 2026. First pitch is scheduled for 7:05 pm in Bronx, NY.

This season, the Blue Jays are 22-27 against the spread (ATS), while the Yankees are 25-24 ATS.

Blue Jays vs Yankees Starting Pitchers Today:

  • Blue Jays starting pitcher: Braydon Fisher 2-1, 3.12 ERA
  • Yankees starting pitcher: Carlos Rodon 0-1, 5.63 ERA

Blue Jays vs. Yankees Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Blue Jays+1.5 -155O 8 -105+140
Yankees -1.5 +125U 8 -115-170

Blue Jays vs Yankees Prediction for Today’s Game

Based on recent trends the model predicts the Yankees will win Thursday‘s MLB game with 56.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Blue Jays players for Thursday‘s game, looking at profitable historical betting trends:

Best Blue Jays Player Prop Bets Today:

  • Ernie Clement has hit the Home Runs Over in 2 of his last 9 games (+17.00 Units / 189% ROI)
  • Davis Schneider has hit the Hits Runs and RBIs Under in 13 of his last 15 games (+11.85 Units / 73% ROI)
  • Daulton Varsho has hit the Total Bases Over in 18 of his last 25 games (+11.85 Units / 37% ROI)
  • George Springer has hit the Runs Under in 19 of his last 25 games (+11.70 Units / 38% ROI)
  • Daulton Varsho has hit the Hits Over in 20 of his last 25 away games (+11.60 Units / 28% ROI)

And here are some favorite MLB player prop bets for Yankees players for Thursday‘s game, looking at profitable historical betting trends:

Best Yankees Player Prop Best Bets Today:

  • Ryan McMahon has hit the Walks Under in 24 of his last 25 games (+21.80 Units / 39% ROI)
  • Ben Rice has hit the Home Runs Over in 7 of his last 10 games at home (+20.65 Units / 207% ROI)
  • Cody Bellinger has hit the Hits Over in 22 of his last 25 games at home (+15.60 Units / 30% ROI)
  • Carlos Rodon has hit the Strikeouts Under in 18 of his last 25 games (+10.95 Units / 37% ROI)
  • Cody Bellinger has hit the Total Bases Over in 11 of his last 15 games at home (+10.50 Units / 70% ROI)
  • The Toronto Blue Jays have hit the 1st Five Innings (F5) Team Total Under in 32 of their last 50 games (+13.85 Units / 24% ROI)
  • The Toronto Blue Jays have covered the Run Line in 16 of their last 24 games (+8.55 Units / 27% ROI)
  • The Toronto Blue Jays have hit the Team Total Under in 17 of their last 25 away games (+8.40 Units / 28% ROI)
  • The Toronto Blue Jays have hit the Game Total Under in 7 of their last 10 away games (+4.90 Units / 45% ROI)
  • The Toronto Blue Jays have covered the 1st Five Innings (F5) Run Line in 5 of their last 6 games (+3.90 Units / 57% ROI)
  • The New York Yankees have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+11.20 Units / 12% ROI)
  • The New York Yankees have hit the Moneyline in 32 of their last 45 games at home (+8.55 Units / 10% ROI)
  • The New York Yankees have hit the Team Total Over in 10 of their last 12 games at home (+7.95 Units / 58% ROI)
  • The New York Yankees have covered the Run Line in 9 of their last 13 games at home (+7.15 Units / 53% ROI)
  • The New York Yankees have hit the 1st Five Innings (F5) Team Total Under in 27 of their last 45 games (+5.95 Units / 11% ROI)

Blue Jays Against the Spread (ATS) Record

Against the spread this season, the Blue Jays are 24-25 against the Run Line (-2.65 Units / -4.25% ROI).

  • 22-27 when betting on the Moneyline for -12 Units / -18.43% ROI
  • 23-24 when betting on the total runs Over for -3.4 Units / -6.28% ROI
  • 24-23 when betting on the total runs Under for -0.95 Units / -1.77% ROI

Yankees Against the Spread (ATS) Record

Against the spread this season, the Yankees are 25-24 against the Run Line (+5.3 Units / 9.95% ROI).

  • 30-20 when betting on the Moneyline for -1.75 Units / -2.2% ROI
  • 22-25 when betting on the total runs Over for -5.7 Units / -10.35% ROI
  • 25-22 when betting on the total runs Under for +0.7 Units / 1.27% ROI

Yankees vs Blue Jays Home Run Prop Bets Today

Yes
Aaron Judge +240
Ben Rice +270
Kazuma Okamoto +325
Trent Grisham +350
George Springer +380

Yankees vs Blue Jays Total Hits Prop Bets Today

Over Under
Vladimir Guerrero Jr. 0.5 -225 0.5 +165
Cody Bellinger 0.5 -210 0.5 +155
Ernie Clement 0.5 -210 0.5 +155
Ben Rice 0.5 -200 0.5 +150
George Springer 0.5 -200 0.5 +145

Yankees vs Blue Jays Strikeout Prop Bets Today

Over Under
Lenyn Sosa 0.5 -275 0.5 +195
Davis Schneider 0.5 -250 0.5 +180
Daulton Varsho 0.5 -250 0.5 +180
Trent Grisham 0.5 -250 0.5 +180
Anthony Volpe 0.5 -235 0.5 +170

Blue Jays Keys to the Game vs. the Yankees

The Blue Jays are just 15-4 (.789) when leading entering the 7th inning this season — tied for 5th lowest in MLB; League Avg: .863.

The Blue Jays are just 2-18 (.100) when allowing 5 or more runs this season — tied for 3rd lowest in MLB; League Avg: .207.

The Blue Jays are just 3-10 (.231) vs the top 10 runs allowed teams this season Today, they face Yankees (fifth in runs allowed).

The Blue Jays are 84-9 (.903) when scoring 5 or more runs since the 2025 season — 2nd best in MLB; League Avg: .796.

Yankees Keys to the Game vs. the Blue Jays

The Yankees are 19-1 (.950) when they’ve hit 2 or more home runs this season — best in MLB; League Avg: .702.

The Yankees are 14-0 (1.000) when they’ve had 10 or more hits this season — best in MLB; League Avg: .754.

The Yankees are 2-14 (.125) when trailing entering the 9th inning this season — tied for 3rd best in MLB; League Avg: .055.

The Yankees are 16-7 (.696) at home this season — 2nd best in MLB; League Avg: .532.

Blue Jays hitters have struck out in just 19% of their PA’s against RHP this season — best in MLB.

Blue Jays hitters have struck out in just 19% of their PA’s this season — tied for best in MLB.

Blue Jays hitters have drawn walks in 7% of their PA’s against RHP this season — 2nd lowest in MLB.

The Blue Jays have scored 58 runs with two outs this season — fewest in MLB.

Yankees hitters have drawn walks in 17% of their PA’s when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Yankees hitters have 104 extra-base hits out of 207 total hits (50%) against starting pitchers this season — best in MLB.

Yankees hitters are slugging .491 at home this season — best in MLB.

Yankees hitters have 60 extra-base hits out of 133 total hits (45%) against LHP this season — best in MLB.

Blue Jays pitchers have allowed an average Exit Velocity of 87.7 MPH (1,165 batted balls) this season — tied for best in MLB.

The Blue Jays pitchers have allowed an average Exit Velocity of just 87.7 MPH this season (1,165 balls in play) — tied for best in MLB

Blue Jays pitchers have struck out 26% of left-handed batters they faced this season — 3rd best in MLB.

Blue Jays pitchers have allowed an exit velocity of 95 MPH or greater 427 times this season — 3rd fewest in MLB.

Opponents have a groundball rate of 49% against Yankees pitchers this season — highest in MLB.

Yankees pitchers have an ERA of 3.34 (442.1 IP) this season — 4th best in MLB.

Yankees pitchers have an ERA of 2.98 (235.1 IP) on the road this season — 2nd best in MLB.

The Yankees have allowed 3.19 runs per game (86/27) on the road this season — 2nd best in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.