• The Cubs are -125 favorites vs the Padres
• Cubs vs Padres Over / Under today: 8 Runs
• Cubs / Padres TV Channel: MARQ | PDTV

The Chicago Cubs (-125) visit Petco Park to take on the San Diego Padres (+105) on April 28, 2026. First pitch is scheduled for 9:40 pm in San Diego, CA.

This season, the Cubs are 17-12 against the spread (ATS), while the Padres are 17-10 ATS.

Cubs vs Padres Starting Pitchers Today:

• Cubs starting pitcher: Edward Cabrera 2-0, 2.80 ERA
• Padres starting pitcher: Walker Buehler 1-2, 5.76 ERA

Cubs vs. Padres Odds, Run Line, Over/Under & Moneyline

Cubs vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Tuesday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Seiya Suzuki has hit the Home Runs Over in 5 of his last 7 games (+21.50 Units / 307% ROI)
• Seiya Suzuki has hit the Total Bases Over in 17 of his last 25 games (+11.15 Units / 37% ROI)
• Seiya Suzuki has hit the Runs Over in 16 of his last 25 games (+10.55 Units / 41% ROI)
• Ian Happ has hit the Walks Under in 19 of his last 25 away games (+9.80 Units / 24% ROI)
• Seiya Suzuki has hit the Hits Over in 19 of his last 25 games (+9.15 Units / 20% ROI)

And here are some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Jackson Merrill has hit the Runs Over in 17 of his last 25 games at home (+12.45 Units / 49% ROI)
• Jackson Merrill has hit the Hits Runs and RBIs Over in 18 of his last 25 games at home (+9.40 Units / 30% ROI)
• Jackson Merrill has hit the Total Bases Under in his last 9 games (+9.15 Units / 77% ROI)
• Fernando Tatis Jr. has hit the Singles Over in 12 of his last 15 games (+7.85 Units / 40% ROI)
• Fernando Tatis Jr. has hit the Hits Over in 12 of his last 15 games at home (+7.75 Units / 25% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Team Total Over in 16 of their last 21 games (+11.15 Units / 45% ROI)
• The Chicago Cubs have hit the Game Total Over in 15 of their last 22 games (+8.40 Units / 34% ROI)
• The Chicago Cubs have hit the Moneyline in 10 of their last 13 games (+7.75 Units / 50% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 24 of their last 40 away games (+5.75 Units / 12% ROI)
• The Chicago Cubs have covered the Run Line in 9 of their last 13 games (+4.75 Units / 27% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 32 of their last 50 games at home (+17.05 Units / 27% ROI)
• The San Diego Padres have hit the Moneyline in 30 of their last 45 games (+13.25 Units / 22% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games at home (+11.70 Units / 20% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 31 of their last 50 games at home (+11.70 Units / 16% ROI)
• The San Diego Padres have hit the Team Total Over in 32 of their last 50 games at home (+11.10 Units / 18% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 14-15 against the Run Line (-1.3 Units / -3.67% ROI).

• 17-12 when betting on the Moneyline for +1.4 Units / 3.55% ROI
• 18-10 when betting on the total runs Over for +7.15 Units / 22.38% ROI
• 10-18 when betting on the total runs Under for -9.85 Units / -30.83% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 17-10 against the Run Line (+5.3 Units / 13.97% ROI).

• 19-9 when betting on the Moneyline for +9.35 Units / 26.26% ROI
• 12-14 when betting on the total runs Over for -3.15 Units / -10.29% ROI
• 14-12 when betting on the total runs Under for +0.8 Units / 2.58% ROI

Padres vs Cubs Home Run Prop Bets Today

Padres vs Cubs Total Hits Prop Bets Today

Padres vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Padres

The Cubs are 53-28 (.654) after a loss since the 2025 season — best in MLB; League Avg: .481.

The Cubs are 59-7 (.894) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .746.

The Cubs are 44-9 (.830) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .636.

The Cubs are 13-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .850.

Padres Keys to the Game vs. the Cubs

The Padres are 2-9 (.182) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .054.

The Padres are 3-7 (.300) when trailing entering the 7th inning this season — tied for 4th best in MLB; League Avg: .150.

The Padres are 13-1 (.929) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .772.

The Padres are 19-9 (.679) this season — 3rd best in MLB; League Avg: .500.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .374 (564 PA’s) with bases empty this season — best in MLB.

Cubs hitters have an OBP of .376 (418 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .288 (590 PA’s) with two-strikes this season — 2nd best in MLB.

Cubs hitters have an OPS of .892 (535 PA’s) over the last 14 days — best in MLB.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Padres hitters have struck out in just 18% of their PA’s against LHP since the 2024 season — best in MLB.

The Padres are batting .190 with two-strikes since the 2025 season — 2nd best in MLB.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers have walked 8% of batters this season — tied for 4th best in MLB.

Cubs pitchers have a strikeout rate of just 19% over the last 14 days — 5th lowest in MLB.

Cubs pitchers have an ERA of 3.31 (486.0 IP) against division opponents since the 2025 season — 3rd best in MLB.

Padres Pitching Stats & Trends

Opponents have a miss rate of 28% against Padres pitchers this season — 3rd best in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — 3rd highest in MLB.

Opponents have a groundball rate of 48% against Padres pitchers this month (23 games) — highest in MLB.

Opponents have a groundball batting average of .325 against Padres pitchers with runners on base this season — tied for 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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