• The Padres are -135 favorites vs the Cubs
• Cubs vs Padres Over / Under today: 7.5 Runs
• Cubs / Padres TV Channel: PEAC | NBCS

The Chicago Cubs (+115) visit Petco Park to take on the San Diego Padres (-135) on September 30, 2026. First pitch is scheduled for 10:00 pm in San Diego, CA.

This season, the Cubs are 89-74 against the spread (ATS), while the Padres are 90-70 ATS.

Cubs vs Padres Starting Pitchers Today:

• Cubs starting pitcher: Kevin Gausman 9-12, 4.50 ERA
• Padres starting pitcher: Nick Pivetta 3-2, 2.86 ERA

Cubs vs. Padres Odds, Run Line, Over/Under & Moneyline

Cubs vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Wednesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Alex Bregman has hit the Walks Over in 14 of his last 25 away games (+11.85 Units / 47% ROI)
• Dansby Swanson has hit the Hits Under in 16 of his last 25 games (+11.15 Units / 44% ROI)
• Ian Happ has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+9.55 Units / 35% ROI)
• Dansby Swanson has hit the Total Bases Under in 17 of his last 25 games (+8.50 Units / 27% ROI)
• Alex Bregman has hit the Home Runs Over in 2 of his last 7 games (+8.30 Units / 119% ROI)

And here are some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• No trends found

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 31 of their last 50 away games (+14.40 Units / 24% ROI)
• The Chicago Cubs have hit the Game Total Over in 29 of their last 45 games (+13.65 Units / 27% ROI)
• The Chicago Cubs have hit the Team Total Over in 32 of their last 50 away games (+11.65 Units / 20% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 19 of their last 35 games (+8.85 Units / 18% ROI)
• The Chicago Cubs have hit the Moneyline in 29 of their last 50 away games (+5.20 Units / 8% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Moneyline in 34 of their last 45 games at home (+21.30 Units / 35% ROI)
• The San Diego Padres have covered the Run Line in 29 of their last 45 games (+15.80 Units / 28% ROI)
• The San Diego Padres have hit the Team Total Over in 31 of their last 45 games (+15.15 Units / 29% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 21 games (+13.35 Units / 54% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 16 of their last 21 games (+13.15 Units / 44% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 76-85 against the Run Line (-5.55 Units / -2.92% ROI).

• 89-74 when betting on the Moneyline for -6.55 Units / -2.95% ROI
• 91-68 when betting on the total runs Over for +16.85 Units / 9.37% ROI
• 68-91 when betting on the total runs Under for -31.4 Units / -17.54% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 90-70 against the Run Line (+15.6 Units / 7.33% ROI).

• 92-71 when betting on the Moneyline for +15.85 Units / 7.88% ROI
• 78-80 when betting on the total runs Over for -10.1 Units / -5.6% ROI
• 80-78 when betting on the total runs Under for -5.15 Units / -2.88% ROI

Cubs Keys to the Game vs. the Padres

The Cubs are 18-30 (.375) when allowing 10 or more hits this season — best in MLB.

The Cubs are 30-35 (.462) when allowing 2 or more home runs this season — best in MLB.

The Cubs are 40-4 (.909) when they’ve had 5 or more XBH this season — 5th best in MLB.

The Cubs are 6-65 (.085) when trailing entering the 9th inning this season — 2nd best in MLB.

Padres Keys to the Game vs. the Cubs

The Padres are 51-30 (.630) at home this season — tied for 4th best in MLB.

The Padres are 39-28 (.582) vs top 10 scoring offenses this season Today, they face the Cubs (first in runs scored).

The Padres are 26-21 (.553) vs the top 10 runs allowed teams this season Today, they face Cubs (12th fewest runs allowed).

The Padres are 73-2 (.973) when leading entering the 8th inning this season — tied for 2nd best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .370 (638 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Cubs hitters have an OBP of .339 (6,382 PA’s) this season — 2nd best in MLB.

Cubs hitters have an OBP of .349 (1,699 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .795 (1,699 PA’s) against LHP this season — best in MLB.

Padres Hitting Stats & Trends

The Padres are batting .368 on the first pitch of at-bats this season — 2nd best in MLB.

Padres hitters have grounded into 124 double plays in 1,078 opportunities (12%) this season — 2nd highest in MLB.

Padres hitters are slugging .623 on the first pitch of at-bats this season — 2nd best in MLB.

The Padres are batting .248 on the road this season — tied for 4th best in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .214 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have picked-off 24 runners this season — most in MLB.

Opponents have a groundball batting average of just .224 against Cubs pitchers this season — best in MLB.

The Cubs have won 40% of road games in which their opponents scored first this season — 3rd highest in MLB.

Padres Pitching Stats & Trends

The Padres have won 46% of home games in which their opponents scored first this season — 2nd highest in MLB.

Padres pitchers have won 35% of games in which they have allowed their opponent to score in three different innings this season — 2nd highest in MLB.

The longest HR allowed by the Padres pitchers this season traveled 453.0 feet — — 5th shortest in MLB

Padres pitchers have a strikeout rate of 29% in close and late situations this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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